[C II] and 12^CO(1-0) emission maps in HLSJ091828.6+514223: a strongly lensed interacting system AT z = 5.24

We present Submillimeter Array [C II] 158 ��m and Karl G. Jansky Very Large Array 12^CO(1-0) line emission maps for the bright, lensed, submillimeter source at z = 5.2430 behind A 773: HLSJ091828.6+514223 (HLS0918). We combine these measurements with previously reported line profiles, including multiple 12^CO rotational transitions, [C I], water, and [N II], providing some of the best constraints on the properties of the interstellar medium in a galaxy at z > 5. HLS0918 has a total far-infrared (FIR) luminosity L_FIR(8���1000 ��m) = (1.6 �� 0.1) �� 10^14 L_��� ��^���1, where the total magnification ��_total = 8.9 �� 1.9, via a new lens model from the [C II] and continuum maps. Despite a HyLIRG luminosity, the FIR continuum shape resembles that of a local LIRG. We simultaneously fit all of the observed spectral line profiles, finding four components that correspond cleanly to discrete spatial structures identified in the maps. The two most redshifted spectral components occupy the nucleus of a massive galaxy, with a source-plane separation <1 kpc. The reddest dominates the continuum map (demagnified L_FIR, component = (1.1 �� 0.2) �� 10^13 L_���) and excites strong water emission in both nuclear components via a powerful FIR radiation field from the intense star formation. A third star-forming component is most likely a region of a merging companion (��V ~ 500 km s^���1) exhibiting generally similar gas properties. The bluest component originates from a spatially distinct region and photodissociation region analysis suggests that it is lower density, cooler, and forming stars less vigorously than the other components. Strikingly, it has very strong [N II] emission, which may suggest an ionized, molecular outflow. This comprehensive view of gas properties and morphology in HLS0918 previews the science possible for a large sample of high-redshift galaxies once ALMA attains full sensitivity.

GPGPU implementation of growing neural gas: application to 3D scene reconstruction

Self-organising neural models have the ability to provide a good representation of the input space. In particular the Growing Neural Gas (GNG) is a suitable model because of its flexibility, rapid adaptation and excellent quality of representation. However, this type of learning is time-consuming, especially for high-dimensional input data. Since real applications often work under time constraints, it is necessary to adapt the learning process in order to complete it in a predefined time. This paper proposes a Graphics Processing Unit (GPU) parallel implementation of the GNG with Compute Unified Device Architecture (CUDA). In contrast to existing algorithms, the proposed GPU implementation allows the acceleration of the learning process keeping a good quality of representation. Comparative experiments using iterative, parallel and hybrid implementations are carried out to demonstrate the effectiveness of CUDA implementation. The results show that GNG learning with the proposed implementation achieves a speed-up of 6�� compared with the single-threaded CPU implementation. GPU implementation has also been applied to a real application with time constraints: acceleration of 3D scene reconstruction for egomotion, in order to validate the proposal.

Workshops in ���Construction of Structures I���: A new teaching methodology in the Building Engineering Degree

Both the current economic situation in the construction sector and the continuous normative changes in the building area imply the use of new methodologies to enhance students��� competences in the degree of Building Engineer. The aim of this paper is to present, analyse and discuss the development of constructive workshops as a new teaching methodology used in the subject of Construction of Structures I at the University of Alicante to complement the constructive and technical knowledge acquired by our students and to enhance their communicative and representation skills essential for their professional practice in the future. The used methodology is based on the development of three-dimensional construction details (in groups of 3 or 4 students) to be shown in two A1-pannels exposed in the corridors of the Polytechnic School. Thus, students��� work approaches constructive problems in a global way by discussing simultaneously with teachers and other groups about the most suitable solution on each case. This contribution has multiperspective results and improves criticism of students in different areas, encouraging new learning strategies and active participation. What is more, on-line information and web applications have been used to prepare and organize this kind of workshops, allowing students to use new technologies as a complementary learning methodology. In conclusion, the use of these new workshops in the Degree of Building Engineer stimulates an interactive class versus a traditional lecture where the participative groups�� attitude and the development of oral presentations dissolve the traditional boundaries regarding public communication skills of the students in the Degree.

La figura del gaucho en la historieta argentina. De las versiones del Mart��n Fierro a Inodoro Pereyra

Entre los m��ltiples personajes propios de la literatura latinoamericana, posiblemente el gaucho argentino ha sido el que ha despertado un mayor inter��s por la creaci��n literaria, con el Mart��n Fierro de Jos�� Hern��ndez como buque insignia de una amplia tradici��n. Esta se ve recogida muy pronto por la narraci��n gr��fica, ya sea a trav��s de las ilustraciones de las ediciones cl��sicas, o en las adaptaciones de las grandes obras en revistas de historietas. Todas ellas van configurando una iconograf��a que completa el imaginario de los guachos, fundamental para la identidad argentina. En el siguiente trabajo haremos una panor��mica de las historietas de gauchos desde las revistas tradicionales, las adaptaciones de obras literarias, como las del Mart��n Fierro, hasta personajes propios como Lindor Covas o Inodoro Pereyra.

Mexico, United States, and Surroundings, 1811 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte du Mexique : et des pays limitrophes situ��s au nord et �� l'est, dress��e d'apr��s la grande cart de la Nouvelle Espagne de Mr. A. de Humbold et d'autres materiaux par J. B. Poirson ; grav�� par Barriere et l'��criture par L Aubert. It was published by F. Schoell in 1811. Scale [ca. 1:8,000,000]. Map in French. Covers portion of North America, including the United States from the 42nd parallel south, Mexico, the Caribbean Islands east to Haiti, and portions of Guatamala, Belize, and Honduras. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'World Mercator' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities, indian settlements and other human settlements, territorial boundaries, shoreline features, and more. Relief is shown by hachures. Includes historical notes. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Jan��b-i Ba-davlatn�� hik��y��tl��r�� : manuscript, 1904 or 5

An eyewitness account of Yaqub Beg's rule in parts of Xinjiang.

HELPING YOUTH WITH AUTISM SPECTRUM DISORDER DEVELOP SOCIAL COMPETENCE IN COMMUNITY-BASED SETTINGS

The purpose of the current dissertation is to identify the features of effective interventions by exploring the experiences of youth with ASD who participate in such interventions, through two intervention studies (Studies 1 and 2) and one interview study (Study 3). Studies 1 and 2 were designed to support the development of social competence of youth with ASD through Structured Play with LEGO TM (Study 1, 12 youths with ASD, ages 7���12) and Minecraft TM (Study 2, 4 youths with ASD, ages 11���13). Over the course of the sessions, the play of the youth developed from parallel play (children playing alone, without interacting) to co-operative play (playing together with shared objectives). The results of Study 2 showed that rates of initiations and levels of engagement increased from the first session to the final session. In Study 3, 12 youths with ASD (ages 10���14) and at least one of their parents were interviewed to explore what children and their parents want from programs designed to improve social competence, which activities and practices were perceived to promote social competence by the participants, and which factors affected their decisions regarding these programs. The adolescents and parents looked for programs that supported social development and emotional wellbeing, but did not always have access to the programs they would have preferred, with factors such as cost and location reducing their options. Three overarching themes emerged through analysis of the three studies: (a) interests of the youth; (b) structure, both through interactions and instruction; and (c) naturalistic settings. Adolescents generally engage more willingly in interventions that incorporate their interests, such as play with Minecraft TM in Study 2. Additionally, Structured Play and structured instruction were crucial components of providing safe and supportive contexts for the development of social competence. Finally, skills learned in naturalistic settings tend to be applied more successfully in everyday situations. The themes are analysed through the lens of Vygotsky���s (1978) perspectives on learning, play, and development. Implications of the results for practitioners and researchers are discussed.

FPGA implementation of a multi-population PBIL algorithm

Evolutionary-based algorithms play an important role in finding solutions to many problems that are not solved by classical methods, and particularly so for those cases where solutions lie within extreme non-convex multidimensional spaces. The intrinsic parallel structure of evolutionary algorithms are amenable to the simultaneous testing of multiple solutions; this has proved essential to the circumvention of local optima, and such robustness comes with high computational overhead, though custom digital processor use may reduce this cost. This paper presents a new implementation of an old, and almost forgotten, evolutionary algorithm: the population-based incremental learning method. We show that the structure of this algorithm is well suited to implementation within programmable logic, as compared with contemporary genetic algorithms. Further, the inherent concurrency of our FPGA implementation facilitates the integration and testing of micro-populations.

Establishing a Robust In Vitro Embryonic Stem Cell Differentiation Assay to Monitor the Hematopoietic Potential of DELES Clones

Afin d���effectuer des ��tudes fonctionnelles sur le g��nome de la souris, notre laboratoire a g��n��r�� une biblioth��que de clones de cellules souches embryonnaires (ESC) pr��sentant des suppressions chromosomiques chevauchantes al��atoires ��� la biblioth��que DELES. Cette biblioth��que contient des d��l��tions couvrant environ 25% du g��nome murin. Dans le laboratoire, nous comptons identifier de nouveaux d��terminants du destin des cellules h��matopo����tiques en utilisant cet outil. Un crible primaire utilisant la benzidine pour d��montrer la pr��sence d'h��moglobine dans des corps embryo��des (EBS) a permis d���identifier plusieurs clones d��l��t��s pr��sentant un ph��notype h��matopo����tique anormal. Comme cet essai ne v��rifie que la pr��sence d'h��moglobine, le but de mon projet est d'��tablir un essai in vitro de diff��renciation des ESC permettant de mesurer le potentiel h��matopo����tique de clones DELES. Mon hypoth��se est que l���essai de diff��renciation h��matopo����tique publi�� par le Dr Keller peut ��tre import�� dans notre laboratoire et utilis�� pour ��tudier l'engagement h��matopo����tique des clones DELES. �� l���aide d���essais de RT-QPCR et de FACS, j���ai pu contr��ler la cin��tique de diff��renciation h��matopo����tique en suivant l���expression des g��nes h��matopo����tiques et des marqueurs de surface comme CD41, c-kit, RUNX1, GATA2, CD45, ��-globine 1 et TER-119. Cet essai sera utilis�� pour valider le potentiel h��matopo����tique des clones DELES candidats identifi��s dans le crible principal. Mon projet secondaire vise �� utiliser la m��me strat��gie r��tro-virale a base de Cre-loxP utilis��e pour g��n��rer la biblioth��que DELES pour g��n��rer une biblioth��que de cellules KBM-7 contenant des suppressions chromosomiques chevauchantes. Mon but ici est de tester si la lign��e cellulaire leu��mique humaine presque haplo��de KBM-7 peut ��tre exploit��e en utilisant l'approche DELES pour cr��er cette biblioth��que. La biblioth��que de clones KBM-7 servira �� d��finir les activit��s mol��culaires de drogues anti-leuc��miques potentielless que nous avons identifi��es dans le laboratoire parce qu���elles inhibent la croissance cellulaire dans plusieurs ��chantillons de leuc��mie my��lo��de aigu�� d��riv��s de patients. Elle me permettra ��galement d'identifier les voies de signalisation mol��culaires qui, lorsque g��n��tiquement perturb��es, peuvent conf��rer une r��sistance �� ces drogues.

The EU cannot remain a passive observer of the Karabakh conflict. EPC Commentary, 7 April 2016

When Federica Mogherini visited the South Caucasus in March, she was quoted as saying that the Nagorno-Karabakh conflict was a top priority for the EU. Facts, however, do not seem to match the words of the EU High Representative for Foreign Affairs and Security Policy. As violent clashes in the conflict zone unfolded over the past week, the EU was a passive observer, with few visible signs of engagement apart from a cursory phone call urging Armenia and Azerbaijan to show restraint. The escalation has shown how quickly and dangerously the situation can develop, and the unassailable nature of the Line of Contact (LoC). If the diplomatic efforts to resolve the conflict show no progress, a repetition is very probable. Furthermore, it is likely the next incident will be more devastating in human and material costs than this recent one, and may not be contained so quickly. The EU needs to be part of the renewed diplomatic effort.

Coreferentiality: A New Method for the Hypothesis-Based Analysis of Phenotypes Characterized by Multivariate Data

Many multifactorial biologic effects, particularly in the context of complex human diseases, are still poorly understood. At the same time, the systematic acquisition of multivariate data has become increasingly easy. The use of such data to analyze and model complex phenotypes, however, remains a challenge. Here, a new analytic approach is described, termed coreferentiality, together with an appropriate statistical test. Coreferentiality is the indirect relation of two variables of functional interest in respect to whether they parallel each other in their respective relatedness to multivariate reference data, which can be informative for a complex effect or phenotype. It is shown that the power of coreferentiality testing is comparable to multiple regression analysis, sufficient even when reference data are informative only to a relatively small extent of 2.5%, and clearly exceeding the power of simple bivariate correlation testing. Thus, coreferentiality testing uses the increased power of multivariate analysis, however, in order to address a more straightforward interpretable bivariate relatedness. Systematic application of this approach could substantially improve the analysis and modeling of complex phenotypes, particularly in the context of human study where addressing functional hypotheses by direct experimentation is often difficult.

Active relaxation counteracts the effects of ego depletion on performance under evaluative pressure in a state of ego depletion

We tested the assumption that active relaxation following an ego-depletion task counteracts the negative effects of ego depletion on subsequent performance under evaluative pressure. N���=���39 experienced basketball players were randomly assigned to a relaxation condition or to a control condition, and then performed a series of free-throws at two points of measurement (T1: baseline vs. T2: after working on a depleting task and either receiving active relaxation or a simple break). The results demonstrated that performance remained constant in the relaxation condition, whereas it significantly decreased in the control condition. The findings are in line with the notion that active relaxation leads to a quicker recovery from ego depletion.

Alteration of the parasite plasma membrane and the parasitophorous vacuole membrane during exo-erythrocytic development of malaria parasites

The rodent malaria parasite Plasmodium berghei develops in hepatocytes within 48-52h from a single sporozoite into up to 20,000 daughter parasites, so-called merozoites. The cellular and molecular details of this extensive proliferation are still largely unknown. Here we have used a transgenic, RFP-expressing P. berghei parasite line and molecular imaging techniques including intravital microscopy to decipher various aspects of parasite development within the hepatocyte. In late schizont stages, MSP1 is expressed and incorporated into the parasite plasma membrane that finally forms the membrane of developing merozoites by continuous invagination steps. We provide first evidence for activation of a verapamil-sensitive Ca(2+) channel in the plasma membrane of liver stage parasites before invagination occurs. During merozoite formation, the permeability of the parasitophorous vacuole membrane changes considerably before it finally becomes completely disrupted, releasing merozoites into the host cell cytoplasm.

Electric Submersible Pumps in Oil Production and Their Efficiency Analysis

The paper describes the structure of electricity consumption of electric submersible pumps. Analyzed the loss of all elements of the pumping unit: the motor, the cable line,transformer, control stations and pump. Discusses how to optimize power consumption of oil production.

Mutational Heterogeneity in Cancer

Thesis (Ph.D.)--University of Washington, 2014-06