Effects of neural nitric oxide synthase gene inactivation on the neurodocrine stress response in mice

Neural nitric oxide synthase, neuroendocrine stress response, forced swimming, nNOS KO mice, hypothalamus, adrenal gland

impact of prenatal stress and neonatal handling on the neuronal development of the rodent limbic system

Prenatal stress, rodent, limbic system, neuronal development, dendritic spines, sex difference

Assessment of Myocardial Ischemia in Obese Individuals Undergoing Physical Stress Echocardiography (PSE)

Background: Physical stress echocardiography is an established methodology for diagnosis and risk stratification of coronary artery disease in patients with physical capacity. In obese (body mass index ≥ 30 kg/m2) the usefulness of pharmacological stress echocardiography has been demonstrated; however, has not been reported the use of physical stress echocardiography in this growing population group. Objective: To assess the frequency of myocardial ischemia in obese and non-obese patients undergoing physical stress echocardiography and compare their clinical and echocardiographic differences. Methods: 4,050 patients who underwent treadmill physical stress echocardiography were studied according to the Bruce protocol, divided into two groups: obese (n = 945; 23.3%) and non-obese (n = 3,105; 76.6%). Results: There was no difference regarding gender. Obese patients were younger (55.4 ± 10.9 vs. 57.56 ± 11.67) and had a higher frequency of hypertension (75.2% vs. 57, 2%; p < 0.0001), diabetis mellitus (15.2% vs. 10.9%; p < 0.0001), dyslipidemia (59.5% vs 51.9%; p < 0.0001), family history of coronary artery disease (59.3% vs. 55.1%; p = 0.023) and physical inactivity (71.4% vs. 52.9%, p < 0.0001). The obese had greater aortic dimensions (3.27 vs. 3.14 cm; p < 0.0001), left atrium (3.97 vs. 3.72 cm; p < 0.0001) and the relative thickness of the ventricule (33.7 vs. 32.8 cm; p < 0.0001). Regarding the presence of myocardial ischemia, there was no difference between groups (19% vs. 17.9%; p = 0.41). In adjusted logistic regression, the presence of myocardial ischemia remained independently associated with age, female gender, diabetes and hypertension. Conclusion: Obesity did not behave as a predictor of the presence of ischemia and the physical stress echocardiography. The application of this assessment tool in large scale sample demonstrates the feasibility of the methodology, also in obese.

Neurochemical consequences of juvenile separation stress: studies in the limbic structures of trumpet-tailed rat (Octodon degus)

Serotonin, dopamine, parental separation, microdialysis, methylphenidate

Dipyridamole stress myocardial perfusion by computed tomography in patients with left bundle branch block

Abstract Background: Functional tests have limited accuracy for identifying myocardial ischemia in patients with left bundle branch block (LBBB). Objective: To assess the diagnostic accuracy of dipyridamole-stress myocardial computed tomography perfusion (CTP) by 320-detector CT in patients with LBBB using invasive quantitative coronary angiography (QCA) (stenosis ≥ 70%) as reference; to investigate the advantage of adding CTP to coronary computed tomography angiography (CTA) and compare the results with those of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy. Methods: Thirty patients with LBBB who had undergone SPECT for the investigation of coronary artery disease were referred for stress tomography. Independent examiners performed per-patient and per-coronary territory assessments. All patients gave written informed consent to participate in the study that was approved by the institution’s ethics committee. Results: The patients’ mean age was 62 ± 10 years. The mean dose of radiation for the tomography protocol was 9.3 ± 4.6 mSv. With regard to CTP, the per-patient values for sensitivity, specificity, positive and negative predictive values, and accuracy were 86%, 81%, 80%, 87%, and 83%, respectively (p = 0.001). The per-territory values were 63%, 86%, 65%, 84%, and 79%, respectively (p < 0.001). In both analyses, the addition of CTP to CTA achieved higher diagnostic accuracy for detecting myocardial ischemia than SPECT (p < 0.001). Conclusion: The use of the stress tomography protocol is feasible and has good diagnostic accuracy for assessing myocardial ischemia in patients with LBBB.

Rotenon-induzierte Komplex I-Inhibierung in primär kultivierten neokortikalen Neuronen : oxidativer Stress, Permeabilitätstransitionsdynamik und die protektive Rolle von Minozyklin

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010

Untersuchungen zur Rolle zellulärer Proteinasen bei der durch oxidativen Stress induzierten Schädigung von Rattenpankreas-Azinuszellen in vitro

Magdeburg, Univ., Medizin. Fakultät, Diss., 2005

Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse brain

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2013

Einfluss von "Stress inoculation" und "Resilience" auf die alters- und geschlechtsspezifische Entwicklung des Angst-, Lern- und Sozialverhaltens von Degus (Octodon degus) und Ratten (Rattus norvegicus)

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014

Untersuchungen molekularer Mechanismen und funktioneller Konsequenzen der DNA-Schädigung durch oxidativen Stress in Tumorzellen

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014

Tratamento térmico da manga: I - variação na temperatura e tempo de imersão

Estudou-se o efeito de tratamentos térmicos no controle das podridões da manga. Os tratamentos constaram na imersão de frutos de 'Haden' em água aquecida nas temperaturas de 45, 50, 55 e 60°C, usando-se para cada temperatura, 3 tempos de exposição 10, 20 e 30 minutos. Apos os tratamentos os frutos foram tratados com o ácido cloroetilfosfônico (Ethefon) a 500 ppm e o experimento foi encerrado no 10º dia após a execução dos tratamentos, com os frutos já maduros. Os melhores tratamentos foram aqueles a 50°C por 30 minutos e a 55°C por 10 minutos, resultando em controle praticamente total da antracnose, Colletotrichum gloeosporioides Penz, e não alteraram nem a aparência, nem os teores de ácidos e sólidos-solúveis dos frutos. Imersões em água a 55°C por 20 minutos e a 60°C por 10 minutos resultaram em escaldadura dos frutos.

Tratamento térmico da manga: II - teste comparativo para cultivares

Frutos de seis cultivares de manga, Oliveira-Neto, Bourbon, Brasil, Extrema, Haden e Imperial foram submetidos a tratamentos por imersão em água quente a 50°C por 30 minutos e a 55°C por 10 minutos visando-se verificar a aceitação destes tratamentos e consequente controle das podridões de antracnose, Colletotrichum gloeosporioides Penz. O experimento mostrou perfeita aceitação pelas cultivares aos níveis de temperatura e tempos de exposição, sendo que os dois tratamentos térmicos conferiram excelente controle das podridões de antracnose para os frutos das seis cultivares amadurecidos que foram à temperatura ambiente.

Statistical analysis of stress and deformation state in polycrystalline aggregates with a large number of grains

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2015

Interneuron function in pathological memory processes : relevance for posttraumatic stress disorder

Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften, Univ., Dissertation, 2015

Efeito da utilização do ácido indolil-3-butírico e do tratamento térmico na propagação vegetativa do gervão (Stachytarpheta elegans L.)

Estudou-se o efeito da aplicação de diferentes concentrações do ácido indoIiI-3-butírico (0, 20, 40, 60, 80, 100 e 200 ppm), em condições de campo e tratadas à frio (15°C), na indução de raízes em estacas de Gervão (Stachytarpheta elegans L.). Através dos dados obtidos concluiu se que houve melhor enraizamento nas concentrações de 40 e 60 ppm, em condições de campo, e que as estacas tratadas com 40 ppm e que posteriormente sofreram tratamento térmico (15°C) por 45 dias, apresentaram grande número de brotações (gemas) na parte aérea.