Molecular Caches: A caching structure for dynamic creation of application-specific Heterogeneous cache regions

CMPs enable simultaneous execution of multiple applications on the same platforms that share cache resources. Diversity in the cache access patterns of these simultaneously executing applications can potentially trigger inter-application interference, leading to cache pollution. Whereas a large cache can ameliorate this problem, the issues of larger power consumption with increasing cache size, amplified at sub-100nm technologies, makes this solution prohibitive. In this paper in order to address the issues relating to power-aware performance of caches, we propose a caching structure that addresses the following: 1. Definition of application-specific cache partitions as an aggregation of caching units (molecules). The parameters of each molecule namely size, associativity and line size are chosen so that the power consumed by it and access time are optimal for the given technology. 2. Application-Specific resizing of cache partitions with variable and adaptive associativity per cache line, way size and variable line size. 3. A replacement policy that is transparent to the partition in terms of size, heterogeneity in associativity and line size. Through simulation studies we establish the superiority of molecular cache (caches built as aggregations of molecules) that offers a 29% power advantage over that of an equivalently performing traditional cache.

Glowworm-inspired robot swarm for simultaneous taxis towards multiple radiation sources

This paper presents a glowworm metaphor based distributed algorithm that enables a collection of minimalist mobile robots to split into subgroups, exhibit simultaneous taxis-behavior towards, and rendezvous at multiple radiation sources such as nuclear/hazardous chemical spills and fire-origins in a fire calamity. The algorithm is based on a glowworm swarm optimization (GSO) technique that finds multiple optima of multimodal functions. The algorithm is in the same spirit as the ant-colony optimization (ACO) algorithms, but with several significant differences. The agents in the glowworm algorithm carry a luminescence quantity called luciferin along with them. Agents are thought of as glowworms that emit a light whose intensity is proportional to the associated luciferin. The key feature that is responsible for the working of the algorithm is the use of an adaptive local-decision domain, which we use effectively to detect the multiple source locations of interest. The glowworms have a finite sensor range which defines a hard limit on the local-decision domain used to compute their movements. Extensive simulations validate the feasibility of applying the glowworm algorithm to the problem of multiple source localization. We build four wheeled robots called glowworms to conduct our experiments. We use a preliminary experiment to demonstrate the basic behavioral primitives that enable each glowworm to exhibit taxis behavior towards source locations and later demonstrate a sound localization task using a set of four glowworms.

Structure of columbin, a diterpenoid furanolactone from Tinospora cordifolia Miers

(1S,4R,5R,8S, IOR,12S)-4-Hydroxy-15,16-epoxycleroda-2,13 (16), 14-trieno- 17,12:18,1-biscarbolactone,C20H2206, Mr = 358.2, m.p. = 453-454 K,orthorhombic, P212121, a = 7.3869 (6), b = 11.986 (1),c=19.896(2) A, V=1761.65A 3, Z=4, D x=1.351, Din(by flotation)= 1.349gem -3, 2(CuKa)=1.5418 A, /l = 8.36 cm -1, F(000) = 760, T= 295 K,R = 0.0432 for 1662 observed reflections. Two terpenerings, two ~-lactones, two methyl groups, a tertiary hydroxyl group and a fl-substituted furan ring are present in the structure. The H atoms at C(12) and C(8) are a- and fl-oriented. The terpene ring A is locked into a boat conformation by the C(1)-C(4) lactone bridge. The furan ring is attached equatoriaUy at atom C(12). The hydroxyl group is involved in intramolecular hydrogen bonding.

Improved synthesis of carbon nanotubes with junctions and of single-walled carbon nanotubes

Pyrolysis of thiophene over nickel nanoparticles dispersed on silica is shown to yield Y-junction carbon nanotubes with smaller diameters than those obtained by the pyrolysis of organometallic-thiophene mixtures. In the presence of water vapour, the pyrolysis of organometallic-hydrocarbon mixtures yields single-walled nanotubes, as well as relatively narrow-diameter carbon nanotubes with Y-junctions. Pyrolysis-of organometallic-hydrocarbon mixtures, in the absence of water vapour, only gives nanotubes with T- and Y-junctions.

Contactless conductivity of nanoparticles from electron magnetic resonance lineshape analysis

A contactless method to determine the electrical conductivity of nanoparticles is presented. It is based on the lineshape analysis of electron magnetic resonance signals which are `Dysonian' for conducting samples of sizes larger than the skin depth. The method is validated bymeasurements on a bulk sample of La0.67Sr0.33MnO3 where it gives values close to those obtained from direct measurement of conductivity and is then used to determine the conductivity of nanoparticles of La0.67Sr0.33MnO3 dispersed in polyvinyl alcohol as a function of temperature. (C) 2010 Elsevier Ltd. All rights reserved.

Teini-ikäisten tyttöjen ruokaturva Zambézian kaupungeissa ja maaseudulla

Johdanto Riittämätön ravinnonsaanti haittaa lasten fyysistä ja psyykkistä kasvua. Se myös heikentää Saharan eteläpuoleisen Afrikan tuottavuutta ja taloudellista kehitystä. Erityisen heikossa asemassa ovat lapset ja hedelmällisessä iässä olevat naiset johtuen nopean kasvun, raskauden ja imetyksen aiheuttamista vaatimuksista. Yleensä ruokaturvattomuus johtuu fyysisestä tai taloudellisesta ruoan hankintamahdollisuuden puuttumisesta ja on näin ollen läheisesti yhteydessä köyhyyteen sekä kestävien elinkeinojen ja turvaverkostojen puuttumiseen. Kaupungistumisen myötä monien afrikkalaisten elinkeinot, ruokatottumukset ja elämäntyyli ovat muuttuneet. Koska elämä kaupungeissa poikkeaa monin tavoin elämästä maaseudulla, myös ruokaturva ja sen taustalla olevat tekijät voivat olla erilaiset kaupungissa ja maaseudulla. Tällöin myös ruokaturvaohjelmat tulee suunnitella asuinpaikan mukaan ja kohdistaa voimavarat tarpeen mukaan. Harvat tutkimukset kuitenkaan tarkastelevat ruokaturvaa yhtä aikaa kaupungissa ja maaseudulla, mistä johtuen ruokaturvan erilaisuudesta näissä eri asuinympäristöissä on vähän tietoa. Tutkimuksen tavoite Tutkimuksen tarkoituksena on selvittää teini-ikäisten tyttöjen ruokaturvan taso Zambézian maakunnan maaseudulla ja kaupungeissa sekä tarkastella onko ruokaturva erilainen maaseudulla ja kaupungeissa. Lisäksi selvitetään mitkä tekijät ovat yhteydessä hyvään ruokaturvaan ja ovatko siihen yhteydessä olevat tekijät erilaisia näissä asuinympäristöissä. Aineisto ja menetelmät Tämä pro gradu -tutkielma on osa suomalais-mosambikilaista yhteistyöprojektia: Teini-ikäisten tyttöjen ravitsemus ja ruokavalio Zambéziassa (Estudo do Estado Nutricional e da Dieta em Raparigas Adolescentes na Zambézia). Tutkimus selvittää 15–18-vuotiaiden teinityttöjen ravitsemustilaa, ruokavaliota ja ruokaturvaa maaseudulla ja kaupunkiympäristössä Zambézian maakunnassa, ennen sadonkorjuuta ja sadonkorjuun jälkeen. Tämä osatutkimus perustuu ennen sadonkorjuuta tammi-helmikuussa 2010 kerättyyn aineistoon (n=277). Ruokaturvaa mitattiin Household Food Insecurity Access Scale (HFIAS) -kyselylomakkeella. Taustatietohaastattelusta poimittiin ruokaturvan kannalta mielenkiintoiset tekijät ja tarkasteltiin niiden yhteyttä ruokaturvaan. Tulokset Ruokaturvan havaittiin olevan huomattavasti parempi maaseudulla kuin kaupungissa. Maaseudulla kotieläimiä omistavat perheet kuuluivat harvemmin huonoon ruokaturvaluokkaan, kuin perheet jotka eivät omistaneet eläimiä. Kaupungissa ylimmässä varallisuustertiilissä olevat perheet kuuluivat keskimmäisessä varallisuustertiilissä olevia harvemmin huonoon ruokaturvaluokkaan. Maaseudun ja kaupungin välillä havaittavaa eroa ruokaturvassa selitti varallisuus. Johtopäätökset Maaseutua ja kaupunkeja tulisi ruokaturvatutkimuksissa käsitellä erillisinä tutkimuskohteina. Erilaiset ruokatottumukset saattavat vaikuttaa koettuun ruokaturvaan kaupungeissa ja maaseudulla. Ruokaturvan taustatekijät ovat myös erilaiset, jolloin ruokaturvattomuuden poistaminen vaatii eri toimintatapoja asuinpaikasta riippuen. Varallisuudella saattaa olla suurempi merkitys ruokaturvan kannalta kaupungeissa kuin maaseudulla. Varallisuuden ja ruokaturvan välisen yhteyden selvittäminen kaupungissa ja maaseudulla vaatii kuitenkin luotettavan varallisuusmittarin. Vuodenaika tulisi ottaa huomioon aiempaa paremmin kun tutkitaan kroonista ruokaturvattomuutta. Ruokaturvatutkimuksissa tulisi kerätä tietoa myös ruokavalion monipuolisuudesta ja tehdä antropometrisiä mittauksia, jotta ruokaturvasta saataisiin kokonaisvaltainen kuva.

Structure of 1,2,4-oxadiazolidine-3,5-dione monohydrate

C2H2N203.H20, Mr= 120.07, monoclinic,P21/c, a= 5.011 (1), b= 11.796(2), c= 7.689 (2)A,fl= 95.22 (2) ° , V= 452.61 A 3, Z= 4, Dx= 1.76, D m = 1.75 gcm -3, /].(Cu Ks) = 1.5418 A, g = 14-0 cm -l,F(000) = 248, T = 293 K, crystal quality was poor and the final R =0.107, wR =0.090 for 881 observed reflections. The compound is derived from a novel form of the monopropellant oxalohydroxamic acid. The two exocyclic C-O bond lengths of 1.240 (3) and 1.228 (4)A indicate double bonds. The C-N bond lengths of 1.334 (4), 1.390 (4) and 1.359 (4) A are characteristic of the amide bond. The N atom covalently bonded to the two carbonyl C atoms acts as a proton donor in an intermolecular hydrogen bond to the ring O atom: N1...O3i = 2.854 ]k (i =x-- 1,y, z), H...O = 2.15 A, N-H...O = 159 °.

Structure of 6-acetoxycoumarin: topochemical photodimerization and analysis of acetoxy...acetoxy interactions in the solid state

C~HaO 4, Mr=204.2, monoclinic, P2Jn,a=3.900(1), =37.530(6), c=6.460(1)A, fl=103.7 (1) °, V= 918.5 (5) A 3, Z = 4, D m = 1.443, D x --- 1.476 Mg m -3, Cu Ks, 2 = 1.5418 ,/k, /t = 0.86 mm -~, F(000) = 424, T= 293 K, R = 0.075 for 1019 significant reflections. Molecules pack in fl-type stacking mode which is characterized by the close packing of parallel and nearly planar reactive double bonds with a separation of 3.900/~ along the a axis.The syn head-head dimer obtained is the direct consequence of this packing arrangement. Molecular packing is stabilized by intermolecular C-H...O hydrogen bonding. Analysis of acetoxy...acetoxy interactions in the acetoxy compounds retrieved from the Cambridge Structural Database reveal that the majority of them are anti-dipolar.

Structure of L-tyrosyl-L-leucine monohydrate

C15H22N204.H20 , Mr= 312.37, monoclinic,P21, a=5.577(2), b=8.686(2), c= 16.228 (2) A,fl=92.63(2) ° , V=785(1)A 3, Z=2, O =1.34,Dx= 1.32Mgm -3, CuKa, 2= 1.54184'~, /2=0.78 mm -I, F(000) = 320, T= 293 K. The final R value for 1607 observed reflections ll,,>_3tr(l,,)l is 0.039. The terminal N 1 is protonated and the dipeptide exists as a zwitterion. The crystal structure is stabilized by extensive hydrogen-bonding interactions involving N and O atoms, with N...O in the range 2.65 (1)-2.95 (1) ,/~ and O...O in the range 2.60 (1)-2.78 (1) A.

Structure of L-Arginyl-L-aspartie Acid Dihydrate

C~0H~gN5Os.2H20, Mr=325.32, monoclinic,P2~, a = 12.029 (2), b=4.904 (2), c=13.215 (2) A, fl= 107.68 (2) ° , F= 743 (1) A 3, Z= 2,D m = 1-45, D x = 1.45 Mg m -3, Cu Ka, 2 = 1.54184 A,fl= 1.01mm -1, F(000)=348, T=293K. The final R value for 1277 observed reflections 110 >_ 3tr(Io)l is 0.031. The dipeptide exists as a zwitterion. The arginyl side-chain conformation is similar to that found in arginyl-glutamic acid [Pandit, Seshadri & Viswamitra (1983). Acta Cryst. C39, 1669-16721. The guanidyl group forms a pair of hydrogen bonds with oxygen atoms of the backbone carboxyl group. The crystal structure is also stabilized by -bonding interactions involving both water molecules.

The structure of ammonium oxalohydroxamate - a monopropellant

Abstract. NHn+.C2H3NzO4, Mr= 137.1, triclinic, Pi, a=3-952(1), b=6.772(1), c=9.993(1)A, a= 98.06 (1), fl= 89.96 (1), ~= 106.96 (1) °. V=253.06 A 3, z = 2, 2(Cu Ka) = 1.5418 A, g =15.29 cm -~, D m = 1.805, D x = 1.798 g cm -3, F(000)= 144, T= 293 K, R = 0.048 for 795 observed reflections. The unit cell contains two independent centrosymmetric molecules, one centred at (0,0,0) and the other at (0.5, 0.0, 0.5). The presence of experimentally determined~N-H groups and the -C=O bond lengths of 1.248 (4) and 1.247 (4)A indicate that the compound exists in the oxamic rather than the oximic form. Only one hydroxyl hydrogen is associated with each molecule. They are located at centres of inversion (0,0.5,0 and 0,0.5,0.5) and are shared between symmetry-related molecules via short symmetric H bonds with O...O=2.454(4), 2.457(4) and all O-H = 1.23 A

Performance comparison of dynamical decoupling sequences for a qubit in a rapidly fluctuating spin bath

Avoiding the loss of coherence of quantum mechanical states is an important prerequisite for quantum information processing. Dynamical decoupling (DD) is one of the most effective experimental methods for maintaining coherence, especially when one can access only the qubit system and not its environment (bath). It involves the application of pulses to the system whose net effect is a reversal of the system-environment interaction. In any real system, however, the environment is not static, and therefore the reversal of the system-environment interaction becomes imperfect if the spacing between refocusing pulses becomes comparable to or longer than the correlation time of the environment. The efficiency of the refocusing improves therefore if the spacing between the pulses is reduced. Here, we quantify the efficiency of different DD sequences in preserving different quantum states. We use C-13 nuclear spins as qubits and an environment of H-1 nuclear spins as the environment, which couples to the qubit via magnetic dipole-dipole couplings. Strong dipole-dipole couplings between the proton spins result in a rapidly fluctuating environment with a correlation time of the order of 100 mu s. Our experimental results show that short delays between the pulses yield better performance if they are compared with the bath correlation time. However, as the pulse spacing becomes shorter than the bath correlation time, an optimum is reached. For even shorter delays, the pulse imperfections dominate over the decoherence losses and cause the quantum state to decay.

Conformation of a 16-residue zervamicin IIA analog peptide containing three different structural features: 310-helix, alpha helix and ß-bend ribbon

Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib- Pro-Ala-Aib-Pro-Aib-Pro-Phe-OM(we here Boc is t-butoxycarbonyla nd Aib is a-aminoisobutyriac cid), a synthetica polar analog of the membrane-activefu ngal peptide antibioticz ervamtycinII A, crystallizesi n spaceg roupP 1 withZ =1 and cell parameters a = 9.086 ?0.002 A, b = 10.410 ?+ 0.002 A, c = 28.188 ? 0.004 A, a = 86.13 ? 0.01?, 13 = 87.90 ? 0.01?, and y = 89.27 ? 0.01?;o veralla greementf actorR = 7.3% for 7180 data (Fo > 3cr) and 0.91-A resolution. The peptide backbone makes a continuous spiral that begins as a 310-helix at the N-terminus, changes to an a-helix for two turns, and ends in a spiral of three fl-bends in a ribbon. Each of the fl-bends contains a proline residue at one of the corners. The torsion angles 4i range from -51? to -91? (average value -64o), and the torsion angles ai range from -1? to -46? (average value -31?). There are 10 intramolecularN H...OCh ydrogenb onds in the helix and two directh ead-to-taihl ydrogenb ondsb etween successive molecules. Two H20 and two CH30H solvent molecules fill additional space with appropriate hydrogen bonding in the head-to-tail region, and two additional H20 molecules form hydrogen bonds with carbonyl oxygens near the curve in the helix at Pro-10. Since there is only one peptide molecule per cell in space group P1, the molecules repeat only by translation, and consequently the helices pack parallel to each other.

Structural Studies of Analgesics and Their Interactions. V.* The Crystal and Molecular Structure of Metamizol Monohydrate

Metamizol, Na[Ct3H16N3045], C13H16N304S-Na +, a sulphonyl derivative of amidopyrine, is perhaps the most widely used non-narcotic analgetic and antiinflammatory pyrazolone derivative. The monohydrate of the compound crystallizes in the monoclinic space group P2Jc with eight molecules in a unit cell of dimensions a = 9.143 (3), b = 49.50 (2), c = 7.314 (2)/k and fl = 90.9 (1) °. The structure was solved by direct methods and refined to an R value of 0.080 for 4466 observed reflections. The two crystallographically independent molecules in the structure have similar dimensions. The elongated molecules are hydrophobic at one end and hydrophilic at the other with the middle portion partly hydrophobic and partly hydrophilic. The pyrazolone group in the structure has dimensions similar to those found in uncomplexed antipyrine and amidopyrine. The crystal structure can be described as consisting of double layers of metamizol molecules stacked perpendicular to the b axis. The adjacent double layers are separated by a layer of Naions and water molecules.