Medicamentos inadequados para idosos na estratégia da saúde da família

The ageing process can change the pharmacodynamics and pharmacokinetics parameters. Therefore, some medications are considered potentially inappropriate (PIM) for the elderly people, since they can increase the likelihood of occurrence of adverse drug events. The objectives are to estimate the frequency of use of PIM in the elderly people, with potentially hazardous drug interactions (PHDI) and to evaluate the impact of pharmaceutical intervention (PI) for the prescription of safer therapeutic alternatives. A cross-sectional study was performed in a Health Family Strategy (region of Araraquara, SP), between January and February/2012. The medical records of patients aged ≥60 years, that use at least one drug, were consulted for identification of PIM, according to the Beers criteria. The MPI identified were classified considering the Anatomical Therapeutic Chemical Classification System (ATC) and the essentiality of the drug (safety, effectiveness, quality and cost parameters) The inclusion criteria were met by 358 elderly, being that 93 of them (26%) had taken at least one PIM. Of the 114 different drugs prescribed for elderly, ten were classified as PIM, of which four of them act on the central nervous system, four on cardiovascular system and two on the digestive tract. Seven MPI are essential medicines, belonging to national list of essential drugs (RENAME-2010). Fourteen drug interactions were identified, of which two are PHDI (fluoxetine/amitriptyline and digoxin/hydrochlorothiazide).After the PI, there was no change in medical prescriptions of patients with PIM use or with DI. Medical prescriptions of elderly attended in the Health Family Strategy show pharmacotherapeutic safety problems, of which may be responsible for health hazardous for this age group. Although the intervention carried out by letter had been ineffective for the adherence of doctors in prescribing safe alternatives, wide dissemination of the lists that contain PIM and PHDI is need, as well as the inclusion of safer equivalents in RENAME, in order to contribute for rational use of drugs.

Development and validation of an economic, environmental friendly and stability-indicating analytical method for determination of ampicillin sodium for injection by RP-HPLC

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Antitubercular drug discovery: the molecular modification as promise tool

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Leishmanicidal activity of different parts from Arrabidaea brachypoda (DC.) Bureau (Bignoniaceae)

Infections by protozoans of the genus Leishmania are the major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which exert renal and cardiac toxicity. Thus, there is a strong need for safer and more effective treatments against leishmaniasis. The present study was designated to evaluate, by a bioguided assay, the leishmanicidal activity of hidro-ethanolic extracts from different parts (leves, caule and root) of one same plant the Arrabidaea brachypoda (DC.) Bureau. Its has been used to relieve general pain, painful joints and kidney stones in Brazilian folk medicine. Nevertheless, scientific information regarding this species is scarce; there are no reports related to its possible leishmanicidal activity. The leves extract presented the best activity on promastigotes forms of Leishmania (L.) amazonensis, when compared to the other extracts. It showed significant activity on Leishmania (L.) amazonensis. Our results are promising, showing that these compounds are biologically active on Leishmania (L.) amazonensis.

Leishmanioses: estado da arte

There is no vaccine available against leishmaniasis. Drug resistance, variable efficacy, toxicity, parenteral administration, and requirement for long courses of administration are the main drawbacks of current leishmanicidal drugs. Infections by protozoans of the genus Leishmania are the major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which exert renal and cardiac toxicity, thus, there is a strong need for safer and more effective treatments against leishmaniasis.

Particularities in the technique of calvaria graft

Calvaria grafts provide good bone quantity for the reconstruction of the atrophic maxilla, and have lower morbidity and resorption rates when compared to iliac crest. The aim of this paper is to present the technique for obtaining a graft of the skull. Initially, the depth of the osteotomy is determined by a manually conducted bur, which establishes the limits of the structures of the skull (outer table, diploe and inner table), making the removal of bone blocks easier and safer. Thus, osteotomies of the blocks are made with greater security, avoiding the complications inherent to surgical technique. The case that will be presented it is from a male patient of 65 years who refused to submit to the iliac crest graft, opting for the calvaria, despite being bald, that is a contraindication for this treatment modality. A delicate suture associated with placement of titanium mesh to maintain the conformation of the patient's skull in the region of the bone defect, created after removal of the graft, provided a good cosmetic result at the donor site. The use of titanium mesh for re-anatomization of bone defects created in the grafts is well indicated for bald patients.

Road safety: implications for sustainable development in Latin America

Road accidents cause more deaths than homicides in Latin America, nevertheless it is not highlighted as a major concern by media and society. World Health Organization put this issue in high priority by releasing the Decade of Action in Road Safety that establishes five pillars to guide national road safety plans and activities. This paper addresses the drawbacks in the implementation of these actions in Latin American countries and its implications to achieve a sustainable development. The main concerns are: lack of empowerment of the road safety management organisations; lower vehicular standards; corruption related to the enforcement of traffic safety laws to and to the construction of safer roads; absence of safety vehicular inspections; vehicle fleet increase, decrease of public transportation demand; and the absence of a safety culture. Without facing these problems, sustainable development in Latin America will be impaired, once road safety is a fundamental link to achieve sustainability.

Ultrassonografia transtorácica extracardíaca: revisão de Literatura

Radiography is usually the primary method of diagnosis to be used in the initial evaluation of the chest. In view of recent technological advances in ultrasound machines, noncardiac transthoracic ultrasound has become an important method of diagnosis for diseases of the lung, pleura, mediastinum and chest wall. Despite limitations due to the difficulty of efficient sound propagation in air, this exam allows fast decisions and makes sample collection safer and more effective. Knowledge of the sonographic chest anatomy is however restricted because of the artifact caused by the presence of air in lungs. When absent, it facilitates the detection of thoracic alterations. The aim of this review is to present the main abnormalities that are likely to be detected by ultrasonography.

Sistema informatizado para dispositivos móveis de coleta dos dados referentes à cesta básica do município de Botucatu/SP

The collection of prices for basic goods supply is very important for the population, based on the collection and processing of these data the CLI (Cost Living Index) is calculated among others, helping consumers to shop more rationally and with a clearer view of each product impact of each product on their household budget, not only food, but also cleaning products and personal hygiene ones. Nowadays, the project of collection of prices for basic goods supply is conducted weekly in Botucatu - SP through a spreadsheet. The aim of this work was to develop a software which utilized mobile devices in the data collection and storage phase, concerning the basic goods supply in Botucatu -SP. This was created in order to eliminate the need of taking notes in paper spreadsheets, increasing efficiency and accelerating the data processing. This work utilized the world of mobile technology and development tools, through the platform".NET" - Compact Framework and programming language Visual Basic".NET" was used in the handheld phase, enabling to develop a system using techniques of object oriented programming, with higher speed and reliability in the codes writing. A HP Pavilion dv3 personal computer and an Eten glofish x500+ handheld computer were used. At the end of the software development, collection, data storing and processing in a report, the phase of in loco paper spreadsheets were eliminated and it was possible to verify that the whole process was faster, more consistent, safer, more efficient and the data were more available.

Avaliação toxicogenética e atividade antitumoral in vitro de complexos heterolépticos de Rutênio(II): Atividades citotóxicas, genotóxicas e interação com biomoléculas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aplicação pré-operatória imediata de antimicrobianos e repercussão cardiorrespiratória e hemodinâmica em cadelas e gatas anestesiadas com isoflurano

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo clínico randomizado e duplo cego comparando dois métodos de escleroterapia para veias reticulares e telangiectasias em membros inferiores

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação dos riscos assistenciais relacionados ao uso de equipamentos hospitalares na unidade de terapia intensiva de adultos de um hospital público da cidade de São Paulo, Brasil

Pós-graduação em Bases Gerais da Cirurgia - FMB

Localizador de faltas por ondas viajantes em linhas de transmissão

It is important to ensure smoothly operation of a transmission line, sending energy to the consumption centers with minimal interruptions and safer. With this necessity, the fault location techniques have grown, in order to mitigate the impact of the fault and its correction can be more quickly and accurately. This paper presents a comparison between two different techniques of fault location, the fault location by impedance method, which uses the line parameters, the impedance per distance, voltage and current signals, and the other is the traveling wave method, which uses only a very fast analysis of time, synchronization and length between the line ends, do not using voltage and current values, but the temporal perception of the fault. Using travelling waves fault detection makes the previous knowledge of line parameters obsolete, which helps a lot network technicians and engineers with a quick and easy analysis. The methods are simulated in ATP Draw software, so both algorithms can be evaluated for their effectively and accuracy

Análise comparativa da incidência de hemólise e resposta inflamatória sistêmica induzida pela circulação extracorpórea em bomba de roletes e em bomba centrífuga em cirurgia de revascularização do micárdio

Pós-graduação em Bases Gerais da Cirurgia - FMB