993 resultados para Roig, Jaume, 1401-1478. Spill
Resumo:
Estudi monogrfic sobre la constituci poltica de lantiga Corona dArag en el temps del regnat de Pere III de Barcelona (1319 1387), dit el Cerimonis, a travs del procs i execuci seguit contra el rei de Mallorques. Shi aborda la situaci histrica, els antecedents, el context internacional, el procediment penal i les conseqncies poltiques. Tamb shi exploren les implicacions doctrinals que, en una poca de confluncia entre les romanalles del feudalisme i leclosi del romanisme humanista, menen a lestabliment dun rgim de garanties constitucionals connectades amb lascens dun poder poltic centrat en la figura del monarca.
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Clinical and experimental evidence suggests that synovial thrombin formation in arthritic joints is prominent and deleterious, leading to exacerbation of rheumatoid arthritis (RA). In this context, cellular effects of thrombin mediated by the protease-activated receptors (PARs) in arthritic joints may be of paramount significance. Four PARs have now been identified. PAR1, PAR3, and PAR4 can all be activated by thrombin whereas PAR2 is activated by trypsin and few other proteases.We first explored PARs expression in RA synovial tissues. Synovial membranes from 11 RA patients were analyzed for PARs expression by RT-PCR and by immunohistology. PAR4 was found in all the biopsies, whereas the expression of PAR1, PAR 2 and PAR3 was more restricted (8/11, 5/11 and 3/11 respectively). In the arthritic synovial membrane of murine antigen-induced arthritis (AIA) we found coexpression of the four different PARs. Next, we explored the functional importance of PAR1 during AIA in vivo using PAR-1 deficient mice. The phenotype of PAR1-deficient mice (n = 22), based on the analysis of arthritis severity (as measured by 99 m tecnetium uptake, histological scoring and intra-articular fibrin measurements) was similar to that of wild-type mice (n = 24). In addition, the in vivo production of antibodies against mBSA was also similar. By contrast, the mBSA-induced in vitro lymph node cell proliferation was significantly decreased in PAR1-deficient mice as compared with controls. Accordingly, mBSA-induced production of interferon-γ by lymph node cells in culture was significantly decreased in PAR1-deficient mice as compared with controls, whereas opposite results were observed for production of IL-10.
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The objective of this paper is to estimate the impact of residential job accessibility on female employment probability in the metropolitan areas of Barcelona and Madrid. Following a spatial mismatch framework, we estimate a female employment probability equation where variables controlling for personal characteristics, residential segregation and employment potential on public transport network are included. Data used come from Microcensus 2001 of INE (National Institute of Statistics). The research focuses on the treatment of endogeneity problems and the measurement of accessibility variables. Our results show that low job accessibility in public transport negatively affects employment probability. The intensity of this effect tends to decrease with individuals educational attainment. A higher degree of residential segregation also reduces job probability in a significant way..
Resumo:
This study analyses the impact that job accessibility in public transport has on car ownership. An ordered probit explaining the number of cars per household is estimated as a function of head of household characteristics, household characteristics and job accessibility. The data used in the analysis come from the Microcensus of year 2001 of the Spanish Institute of Statistics for the areas of Barcelona and Madrid. Our results show a significant effect of accessibility on car ownership. Additionally, we carried out simulation exercises in which the expected number of vehicles decreases as accessibility improves. For instance, in the case of households living outside the central city, an improvement of accessibility up to the average level of the central city would offset the effect of the number of working adults on the expected number of vehicles.
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An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.
Resumo:
Empleando la encuesta de estructura salarial se plantea una propuesta de estimacin de externalidades de capital humano intraempresa que permite relajar las restricciones introducidas por las especificaciones que la literatura emprica existente ha usado. En concreto, la metodologa propuesta evala las externalidades de capital humano aprovechando al mximo la variabilidad en la muestra, al permitir que todos los coeficientes de las ecuaciones estimadas varen con el nivel de capital humano del establecimiento, relajando la hiptesis implcita de linealidad entre el efecto de externalidad y el nivel educativo de los individuos.
Resumo:
En este documento se analizan comparativamente algunos aspectos relativos al capital humano de la economa catalana y espaola. En primer lugar se compara la dotacin de capital humano tanto desde una metodologa ms tradicional, como es el caso de aos de educacin, como desde el punto de vista de la valoracin del activo mediante actualizacin de flujos salariales a lo largo del ciclo vital de los individuos. Los resultados muestran indicios de una cierta desaceleracin en el crecimiento del stock de capital humano. Adicionalmente, se lleva a cabo una estimacin de la existencia de externalidades de capital humano intra-establecimiento, con datos de la Encuesta de Estructura Salarial, desarrollando una metodologa menos restrictiva que la tradicional. Los resultados muestran comportamientos similares de la economa espaola y catalana, apuntando a la existencia de externalidades.
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Treball de recerca realitzat per una alumna densenyament secundari i guardonat amb un Premi CIRIT per fomentar l'esperit cientfic del Jovent lany 2008. El ram passa per una srie de processos durant la seva etapa de maduraci i creixement, abans de ser collit. Mitjanant prctiques culturals es poden modificar aquests processos per tal dobtenir el ram adequat per lelaboraci vincola. Shan estudiat els efectes de dues daquestes tcniques utilitzades habitualment sobre la qualitat de la producci de ram: laclarida dels fruits i lespampolament dels ceps. Per determinar-los, es va dur a terme un treball de camp a una parcella de vinya de lAlt Empord, en la qual es varen diferenciar sis fileres de ceps amb una tcnica de conreu diferent. Per observar les variacions es va anar fent un seguiment de cada tesi per separat, controlant els valors de pH, acidesa total, sucres i grau alcohlic probable. El seguiment es va fer durant un perode de vint-i-set dies i amb una regularitat de quatre dies. Treballant els resultats obtinguts i mitjanant grfics en qu es poden observar els efectes de cada prctica, sha determinat quins sn els efectes de la disminuci de la crrega i del desfullat sobre la maduraci del ram.
Resumo:
Treball de recerca realitzat per alumnes densenyament secundari i guardonat amb un Premi CIRIT per fomentar l'esperit cientfic del Jovent lany 2008. La pastilla anticonceptiva masculina s un producte qumicament possible per encara no llenat al mercat. El motiu de la recerca ha estat investigar per comprovar si el disseny duna campanya de mrqueting tindria xit en la promoci daquest producte. En primer lloc, sha dut a terme una recerca terica sobre lanticoncepci i el mrqueting. En segon lloc, sha realitzat un treball de camp en dues parts. Duna banda shan confeccionat enquestes avaluant lacceptaci del producte en la poblaci. De laltra shan realitzat entrevistes a professionals: sexleg-psicleg, ginecleg, publicista i farmacutica.Posteriorment sha dissenyat la campanya de mrqueting, gravat lespot televisiu i dissenyat una pgina web.
Resumo:
Most research in gout has concentrated on the proinflammatory mechanisms to explain the inflammation that is generated when leucocytes are in contact with monosodium urate crystals. However, the episodic nature of gout and the absence of inflammation even when crystals are present suggest that there are natural counter-regulatory mechanisms to limit the inflammatory response. Gagn and colleagues showed that myeloid inhibitory C-type lectin, a C-type lectin inhibitory receptor expressed on neutrophils, modulates monosodium urate-induced neutrophil responses in vitro.
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Sha optimitzat un motor de veu natural per a dispositius mbils com una PDA o un telfon mbil basat en un sistema operatiu Windows. La finalitat daquest treball s la dajudar a fer ms fcil la utilitzaci daquests aparells a gent invident i que pugui acabar sent una donaci a la ONCE.
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El proyecto consisti en el estudio, propuesta y realizacin de una serie de mejoras derivadas del anlisis de un sistema de gestin de expedientes. El sistema analizado es SEDAS, un producto de gestin de los procesos de recobro de deudas desarrollado por Steria. Las mejoras se concentraron en la parametrizacin y mejora de diversos apartados tales como el modelo de datos, el sistema de generacin de informes o la interfaz grfica.
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Projecte d'adaptaci del programa GNU Chess al sistema de grid computing 'Condor'. I amb aix, es planteja un estudi sobre els algorismes de cerca i la seva aplicaci en entorns distributs. Una srie de proves sobre unes mostres de una partida d'escacs contra el propi GNU Chess ens ajuden a posar de relleu els avantatges i inconvenients de cada un dels algorismes proposats.
