Reproduction and sera embryotoxicity after immunization of monkeys with the laminin peptides YIGSR, RGD, and IKVAV.

Monkeys with excellent reproductive histories were immunized with the laminin peptides YIGSR, RGD, IKVAV, and YD, a control sequence with no known biological function. Sera from the YIGSR-immunized monkey became toxic, causing neural tube defects in whole rat embryo cultures, and this monkey experienced fetal loss after immunization. Sera from the RGD-immunized monkey also became embryotoxic in culture after immunization, but this monkey appeared to become infertile as she failed to initiate a pregnancy for at least 2 years after immunization. In contrast, embryos cultured on sera from the IKVAV- or YD-immunized monkeys were predominantly normal and both monkeys completed successful pregnancies. Antibody levels to the respective peptides or to laminin were not predictive of embryotoxicity, but antibody binding to homogenized yolk sacs as well as to yolk sacs of cultured embryos was associated with sera embryotoxicity and reproductive outcomes in vivo. These observations suggested that the laminin sequences YIGSR and RGD may play a role in immune-mediated reproductive failure by reacting directly with embryonic tissue and could provide a basis for identifying individuals at risk for both spontaneous abortion and infertility.

Notes on growth and reproduction of the slimy salamander Plethodon glutinosus [by] Clifford H. Pope and Sarah H. Pope.

v.31:no.29(1949)

Effects of suspended solids and sediment on reproduction and early life of warmwater fishes : a review /

Mode of access: Internet.

Andromaque : reproduction of the text of 1697--the last printed in the lifetime of Racine.

Mode of access: Internet.

The genetics of schizophrenia; a study of heredity and reproduction in the families of 1,087 scizophrenics,

"This first edition ... printed in Germany."

Catalogue de bons livres anciens et modernes et collection nombreuse d'épreuves photographiques reproduction des plus beaux tableaux et dessins des différents musées de l'Europe,

Preface signed: P.-L. Jacob, bibliophile [pseud. of Paul Lacroix]

Supplemental report for the red algal sexual reproduction test : training videotape /

Mode of access: Internet.

Histoire romaine de Tite-Live : reproduction réduite du manuscrit en onciale, latin 5730 de la Bibliothèque nationale.

Facsimile of the Codex Puteanus (now Ms. lat. 5730 in the Bibliothèque nationale, Paris) containing the third decade, or book XXI (chap. 20 [sect. 8-chap. 21] [sect. 13; chap. 29] [sect. 6-chap. 30] [sect. 11; chap. 41] [sect. 13 to end (chap. 63)); books XXII-XXIX; book XXX (chap. 1-30 [sect. 14; chap. 37] [sect. 3-chap. 38] [sect. 3])

Reproduction of farm animals and their improvement through testing and selection,

Mode of access: Internet.