Lipoperoxidação, perda de viabilidade celular e diminuição da liberação de IL-8 de neutrófilos humanos na presença de corpos cetônicos

Type-1 diabetes patients suffer from frequent episodes of acidosis caused by an increased fatty acid metabolism and consequently increased plasma level of acetoacetate (AcAc) and β-hydroxybutyrate (β-HOB). This article describes a study of the effects of pathological concentrations of AcAc and β-HOB on lipoperoxidation, cell viability and the release of the CXCL8 (IL-8) cytokine by activated neutrophils. Neutrophils from healthy donors were isolated by density gradient (Histopaque® 1077/1119) and incubated with the ketone bodies. Lipoperoxidation was determined as thiobarbituric acid reactive substances (TBARS). The cell viability was evaluated by the release of intracellular lactate dehydrogenase. The release of CXCL8 was measured by ELISA in a 24-h culture of opsonized zymosan-stimulated neutrophils. AcAc, but not β-HOB, provoked a dose-dependent increase in the neutrophil membrane lipoperoxidation (p<0.05; r =0.9915). In the cytotoxicity assay, a dose-dependent release of LDH was observed when the neutrophils were incubated with AcAc in concentrations up to 40 mM (p<0.05). β-HOB was devoid of effect. The release of CXCL8 was inhibited by AcAc and β-HOB in a dose-dependent manner. In conclusion, these results suggest that the accumulation of ketone bodies in diabetic patients could be involved in their usually increased susceptibility to infection.

Evolução da perda de peso entre indivíduos da fila de espera para a cirurgia bariátrica em um ambulatório multidisciplinar de atenção secundária à saúde

Objective: The objective of this study is to characterize the assistance and analyze patient's adherence to nutritional follow-up while in the waiting line for bariatric surgery in a multidisciplinary, secondary healthcare outpatient clinic. Methods: This retrospective study was based on the nutritional records of 59 patients subjected to bariatric surgery at the Hospital das Clinics de Botucatu, from 2001 to 2008. The population studied was distributed into 8 groups and analyzed according to follow-up duration. The analysis took into account the evolution of body weight and the number of follow-up visits in a given period. The Kruskal-Wallis test was used to compare data between groups while Spearman's coefficient was used to test correlations. Results: Among the 59 studied patients, 42 (71.2%) returned to the clinic at least once in six months. Of these, 67.8% lost weight while in the waiting line and 27.1% of them lost more than 10% of their body weight. The greatest weight losses in the preoperative period were found in the groups that had more than six months of nutrition follow-up. There was a mean delay of three months between return visits, which could have contributed to the low adherence to follow-up. Conclusion: The patients in the waiting line for surgery analyzed in this study presented low adherence to the long-spaced return visits. The greatest weight losses were observed in groups that had been followed for more than six months. This shows that, to achieve the desired weight loss and an adequate education process before surgery, at least six months of follow-up and regular visits are necessary.

Sistema especialista para a monitoração do processo de degradação de medidores tipo indução de energia elétrica ativa

This paper presents a methodology and software for hazard rate analysis of induction type watt-hour meters, considering the main variables related with the degradation process of these meters, for the Elektro Electricity and Services SA. The modeling developed to calculate the watt-hour meters hazard rate was implemented in a tool through a user friendly platform, in Delphi language, enabling not only hazard rate analysis, but also a classification by risk range, localization of installation for the analyzed meters, and, allowing, through an expert system, the sampling of induction type watt-hour meters, based on the model risk developed with artificial intelligence, with the mainly goal of follow and manage the process of degradation, maintenance and replacement of these meters. © 2010 IEEE.

Conversor CA-CA de elevado fator de potência para aplicações com geradores de Ímã permanente

This paper proposes and describes a high power factor AC-AC converter for naval applications using Permanent Magnet Generator (PMG). The three-phase output voltages of the PMG vary from 260 Vrms (220 Hz) to 380 Vrms (360 Hz), depending on load conditions. The proposed converter consists of a Y-/ΔY power transformer, which provides electrical isolation between the PMG and remaining stages, and a twelve-pulse uncontrolled rectifier stage directly connected to a single-phase inverter stage, without the use of an intermediary DC-DC topology. This proposal results in more simplicity for the overall circuitry, assuring robustness, reliability and reduced costs. Furthermore, the multipulse rectifier stage is capable to provide high power factor and low total harmonic distortion for the input currents of the converter. The single-phase inverter stage was designed to operate with wide range of DC bus voltage, maintaining 120 Vrms, 60 Hz output. The control philosophy, implemented in a digital signal processor (DSP) which also contains protection routines, alows series connections between two identical converters, achieving 240 Vrms, 60 Hz total output voltage. Measured total harmonic distortion for the AC output voltage is lower than 2% and the input power factor is 0.93 at 3.6kW nominal load. © 2010 IEEE.

Perda de carga em mangueiras gotejadoras novas e usadas

This paper aims to determine the importance of emitter ́s local head loss in the hydraulic design of hose drip lines, as well as comparing the result of equations that calculate the local head loss; besides verifying the influence of iron precipitated at the hose head loss made in Brazil. The result found that localized head loss represents 23% of the total head loss; the equations showed significant results and the total head loss increased in an average of 20% after the irrigation system was used with water rich in iron.

Fluxo de potência trifásico probabilístico para redes de distribuição usando o método de estimação por pontos

In this paper the point estimation method is applied to solve the probabilistic power flow problem for unbalanced three-phase distribution systems. Through the implementation of this method the probability distribution functions of voltages (magnitude and angle) as well as the active and reactive power flows in the branches of the distribution system are determined. Two different approaches of the point estimation method are presented (2m and 2m+1 point schemes). In order to test the proposed methodology, the IEEE 34 and 123 bus test systems are used. The results obtained with both schemes are compared with the ones obtained by a Monte Carlo Simulation (MCS).

Predição da potência aeróbia (VO 2máx) de crianças e adolescentes em teste incremental na esteira rolante

The maximal oxygen uptake (VO2max) is the maximal quantity of energy that can be produced by the aerobic metabolism in certain time unity. It can be determined direct or indirectly by predictive equations. The objective of this study was to make a specific predictive equation to determine the VO 2max from boys aged 10-16 years-old. Forty-two boys underwent a treadmill running ergospirometric test, with the initial velocity set at 9 km/h, until voluntary exhaustion. By the multiple linear regression was possible to develop the following equation for the indirect determination of the VO 2max: VO2max (ml/min) = -1574.06 + (141.38 x Vpeak) + (48.34 * Body mass), with standard error of estimate = 191.5 ml/min (4.10 ml/kg/min) and coefficient of determination = 0.934. We suggest that this formula is appropriate to predict VO2max for this population.

Perda e luto: Vivências de mulheres que interromperam a gestação por malformação fetal letal

The scope of this study was to investigate the grieving experiences of women who terminated pregnancies under judicial authorization, due to life-incompatible fetal malformation. Ten women attended in the Fetal Medicine Department of Botucatu Clinical Hospital participated in the study. Data collection was conducted by means of semi-structured interviews forty days after termination. The interviews were recorded and transcribed in full, with the data analyzed from the thematic content analysis perspective. The results revealed that the mothers sought explanations and meanings for the loss, with religious responses and self-blame being very frequent. The reports were marked by feelings of sadness, longing and sensations of emptiness due to the loss of the child, revealing the need of the mothers to dwell on the issue. The mothers were and continued to be linked to their children; the termination of the pregnancy, although being a choice to minimize the pain of an inevitable loss, did not spare the women from experiences of great suffering. The study includes input for the discussion and planning of health approaches and care for women who terminate their pregnancy due to lethal fetal malformation, by means of judicial authorization.

Estimativa das radiações ultravioleta (UV), fotossintéticamente ativa (PAR) e infravermelha (IV) em função da razão de insolação

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Integridade, disponibilidade e acurácia no posicionamento RTK e RTK em rede: Investigação no contexto da rede GNSS ativa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Modelação e análise da vida útil (metrológica) de medidores tipo indução de energia elétrica ativa

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Sistema de extração de potência (power harvesting) usando transdutores piezelétricos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fenômenos não-lineares, incluindo-se os não-ideias, em captura de energia utilizando-se dispositivos piezoelétricos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Retificador boost entrelaçado com elevado fator de potência e sem ponte de diodos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Detecção e classificação de faltas de alta impedância em sistemas elétricos de potência usando lógica Fuzzy

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)