980 resultados para Modular electronics
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"23 May 1983."
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"1 June 1983."
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Issued Sept. 1976.
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"November, 1970."
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Mode of access: Internet.
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Mode of access: Internet.
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Previously pub., in part, as chapters 1 to 8, and 12 of Kloeffler's Industrial electronics and control.
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Mode of access: Internet.
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Includes bibliographical references.
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Includes bibliography.
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Includes bibliography.
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"An INSPEC publication."
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Thesis (Master's)--University of Washington, 2016-06
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Thesis (Ph.D.)--University of Washington, 2016-06
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A 13-residue peptide sequence from a respiratory syncitial virus fusion protein was constrained in an alpha-helical conformation by fusing two back-to-back cyclic alpha-turn mimetics. The resulting peptide, Ac-(3 -> 7; 8 -> 12)-bicyclo-FP[KDEFD][KSIRD]V-NH2, was highly alpha-helical in water by CD and NMR spectroscopy, correctly positioning crucial binding residues (F488, I491, V493) on one face of the helix and side chain-side chain linkers on a noninteracting face of the helix. This compound displayed potent activity in both a recombinant fusion assay and an RSV antiviral assay (IC50 = 36 nM) and demonstrates for the first time that back-to-back modular alpha-helix mimetics can produce functional antagonists of important protein-protein interactions.