Efeitos do treinamento em natação sobre propriedades mecânicas e estruturais do fêmur de ratas ovariectomizadas

We investigated the effects of swimming training (ST) on femoral mechanical and structural properties in ovariectomized female rats. Female Wistar rats [age = 20 weeks; body weight (BW) = 271,42 +/- 17,6 g] were subjected to ovariectomy (OVX) or laparotomy (SHAM) and allocated to one of the following groups: swimming OVX (SO, n=12), control OVX (CO, n=12), swimming SHAM (SS, n=12) and control SHAM (CS, n=12). Fifteen days after surgery SO and SS groups were subjected to a ST (60 min/day, 5 days/week, overload of 3% of BW) for 10 weeks. Alkalin phosfatase was reduced in OVX as compared to SHAM (18,87 pg/mL vs. 53,93 pg/mL, respectively), but not altered by ST. Animals SHAM showed more cancellous bone than OVX (255,50 +/- 38,27 vs 288,75 +/- 39,63 points, respectively). Exercised animals exhibited more cancellous bone than controls (292,00 +/- 33,54 vs 251,54 +/- 38,99 points, respectively) in this region and in the grater trochanter (281,50 +/- 34,42 vs 237,23 +/- 53,03 points; respectively). Bone mineral density and cortical bone in the femur midshaft were not altered either by OVX or ST. The maximum force and thoughness of the femoral neck and midshaft were not affected either by OVX or ST. It was concluded that ST benefits cancellous bone mass in the femoral proximal region (i.e. femoral neck and greater trochanter), independently of ovariectomy, which did not reflect in improved mechanical properties either in the femoral neck or midshaft.

Treinamento em corrida de baixa intensidade: propriedades estruturais e mecânicas da epífise proximal do fêmur de ratas osteopênicas

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise do potencial osteogênico de células estromais derivadas da medula óssea de ratas adultas e senis submetidas ou não ao treinamento de força

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desempenho de frangos de corte e produção de energia em biodigestores, utilizando-se três tipos de cama

Pós-graduação em Zootecnia - FCAV

Excess body fat negatively affects bone mass in adolescents

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise da densidade óssea de rádio-ulna de cães SRD utilizando o método de imersão

Imaging diagnosis is a medical specialty that uses imaging techniques to perform diagnosis. In diagnostic imaging various methods are used such as direct absorption of photons - SPA and DPA, radiographic photometry, the dual-energy radiographic absorptiometry - DEXA, ultrasound, magnetic resonance imaging, computed tomography and optical densitometry in radiographic image. The dog can be considered one of the most widely used animals in the study of bone diseases and searching for a reliable diagnosis, although not an ideal model for the study of osteoporosis, because these animals tend not to develop a decrease in bone mineral density. The objective of this study was to analyze bone density in mongrel dogs from the determination of the variation of density along the radio-ulna bone and also the mean value related to gender, weight and age of individuals. The density analysis carried out showed that for this data set, there is a significant difference in the case of gender and age of the animal and may generalize according to these variables. The only significant difference was found in the weight, which increases bone mass is related to weight gain through the growth of the animal

Efeito da administração de alendronato, a longo prazo, sobre as propriedades mecânicas do tecido ósseo, sua reparação e mineralização ao redor de implantes osseointegráveis. Estudo em ratas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise histomorfométrica do reparo ósseo em tíbias de ratos castrados submetidos ao efeito do alendronato sódico

This study used histomorphometric analysis to investigate the effect of sodium alendronate, used for the treatment of osteoporosis, on the repair of surgically-induced bone defects in the tibia of castrated rats. Methods: The castrated animals were given subcutaneous injections of sodium alendronate (0.7mg/Kg) diluted in saline once a week; the control animals were given the same dose of saline. At 16, 30 and 44 days after the first injection of sodium alendronate, the animals were sacrificed and the right tibias were removed and processed for histomorphometric analysis. The volumetric bone mineral density was estimated by a reticular grid (25 points) attached to a light microscope. The number of points on the bone tissue was counted in the histological sections, totaling 100 points/animal. Results: The results revealed that sodium alendronate stimulated bone formation in castrated rats in all occasions, mainly at 16 and 30 days. Conclusion: Sodium alendronate affects mineral homeostasis, promoting bone repair.

Influência da obesidade sobre o tecido ósseo de Rattus novergicus albinus idosos, submetidos à suspensão pela cauda e ao exercício resistido

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Plasma rico em plaquetas, medula óssea ou quitosana nas osteossínteses minimamente invasivas na tíbia de cães

Pós-graduação em Cirurgia Veterinária - FCAV

Influence of Estrogen Deficiency on Bone Around Osseointegrated Dental Implants: An Experimental Study in the Rat Jaw Model

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Exercício resistido no tratamento e prevenção de osteopenia de ratos machos jovens

Pós-graduação em Ciência Animal - FMVA

Análise do consumo de extato hidrossolúvel de soja na qualidade do tecido ósseo de ratos jovens adultos

Pós-graduação em Ciência Animal - FMVA

Evaluation of femur of orchiectomized guinea pigs by bone densitometry using dual-energy x-ray absortiometry (DXA) and mechanical testing

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Laser terapêutico no reparo ósseo de ratos submetidos à ausência de carga

Low-intensity laser has been used as a physical agent in various fields of medical sciences such as bone and tissue repair. Meanwhile little is known about its effects in adverse conditions such as abolition of load and osteopenic. With the assumption that the laser Ga-Al-As accelerates the process of bone consolidation, goal of this study was to evaluate bone mineral density (BMD) in incomplete transverse osteotomies of tibia in adult rats, treated with low power laser therapy in three different groups: G1 (n = 10), reference 15 days; G2 (n=10), suspended by the tail and, accordingly, treated with laser for 12 days; G3 (n = 10), suspended by the tail by 36 days and that after 21 days, there was laser treatment for 12 days. The right tibia treated with laser and left served as control. The laser was used to Ga-Al-As, DMC - Flash Lase® III, with wavelength 830nm, 100 mW, 4J, 140 J / cm ², 40s of application in 12 sessions. It was used densitometer-Lunar DPX®, with computer program for "small animals", and the analysis of BMD was made in the bone throughout the region and the osteotomy. The results showed no efficacy of laser therapy in the process of bone repair, both in animals of group 1, as in group 2 and 3. It follows that either the low-power laser was not an effective performance or the effects of laser therapy is not only manifested at the site of irradiation as well as the systemic level.