The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.

Cul3 (Cullin3)-based E3 ubiquitin ligases recently emerged as critical regulators of mitosis. In this study, we identify two mammalian BTB (Bric-a-brac-Tramtrack-Broad complex)-Kelch proteins, KLHL21 and KLHL22, that interact with Cul3 and are required for efficient chromosome alignment. Interestingly, KLHL21 but not KLHL22 is necessary for cytokinesis and regulates translocation of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase, similar to the previously described BTB-Kelch proteins KLHL9 and KLHL13. KLHL21 directly binds to aurora B and mediates ubiquitination of aurora B in vitro. In contrast to KLHL9 and KLHL13, KLHL21 localizes to midzone microtubules in anaphase and recruits aurora B and Cul3 to this region. Together, our results suggest that different Cul3 adaptors nonredundantly regulate aurora B during mitosis, possibly by ubiquitinating different pools of aurora B at distinct subcellular localizations.

La pratique de l'hydrothérapie / par É. Duval,... ; préface par M. le professeur Peter,...

Collection : Bibliothèque du médecin praticien

Positiones philosophicae ex fragrantissimo philosophiae viridario carptìm collectae. Quas ex consensu amplissimae [et] venerandae facultatis philosophicae in Regiâ Academiâ Aboënsi. Sub praesidio, ... dn. Michaelis Gyllenstålpes, Wexionii, j. u. & philos: doct: pereximii, ll:m polit: & hist: prof: publ: celeberrimi, p. t. rectoris magnifici, moecenatis, praecept. ac promotoris quovis obsequii & honoris genere plurimùm prosequendi. Liberalis exercitij gratia, publicae eruditorum disquisitioni modestè sistit Daniel B. Rosander Smolandus s. r. m.tis stipendiarius. In auditorio majori ad diem 22. Novemb. anno 1654. Horis ab 8. antemeridianis

Variantti A.

Indenture between John Picard and Peter Servos

Indenture of mortgage in fee between John Picard of the Township of Niagara and Peter Servos of the Township of Niagara regrading part of Lot no. 113 in the Township of Niagara - instrument no. 6269. This is listed in book B, folio 33, August 17, 1855.

Province of Upper Canada Grant to the Honorable Peter Russell of the Township of Newark

Province of Upper Canada Grant to the Honorable Peter Russell of the Township of Newark. He is granted 150 acres in the Town of Newark in the County of Lincoln. This is registered in Liber B, folio 133. This was entered in the auditor’s office July 26, 1796. This document is held together with tape. The text is not affected, July 2, 1796.

Entrevista a Peter Maclntyre. 'Entrevisa a Peter Maclntyre'.

Peter Maclntyre ha estudiado las motivaciones que empujan a muchas personas a aprender y utilizar una segunda lengua. Los beneficios economicos que se derivan son, a ojos de este profesor de psicologia de canadá, sencillamente la parte más prosaica de la cuestión. Ser más tolerante con otras culturas o recuperar la propia indentidad perdida son algunos de los buenos motivos para estudiar otro idioma. El mes de marzo pasado , Maclntyre participó en la presentación de la Cátedra de Multilinguismo Linguamón-UOC, creada conjuntamente por la Casa de les Llengües y la Universitat Oberta de Catalunya.