Engineers for the public good : a history of the Buffalo District, U.S. Army Corps of Engineers /

Includes bibliographical references and index.

Priority treatment for high occupancy vehicles : project status report /

Mode of access: Internet.

Cellar chats in the Verdier Cellars /

Cover title.

Glue and gelatin,

Bibliographical foot-notes.

The adjustment service; a report of an experiment in adult guidance

Mode of access: Internet.

Sancti Eusebii Hieronymi Epistulae /

Includes bibliographical references and indexes.

Reports of cases heard and determined in the Appellate Division of the Supreme Court of the state of New York /

Reporters: 1896-1905, M.T. Hun.--1906-1919, J.B. Fisher.--1920-1942, A.B. Griffin.

Advanced public transportation systems : a bibliography with abstracts /

"DOT-T-92-18."

The Golconda bonanza,

Mode of access: Internet.

Imaginative literature,

Bibliography: v. 1, p. 234-237; v. 2, p. 249-254.

Oral rehabilitation; complete occlusal reconstruction treatment of dental deformities and related subjects, the closed bite.

Mode of access: Internet.

Na 1 Nachlass Max Horkheimer, 530 - Korrespondenzen u.a. mit Julian Gumperz (p. VI 10, 201 - 359)

80 Briefe zwischen Julian und Lotte Gumperz und Max Horkheimer, 1934 - 1942; 1 Brief von Max Horkheimer an Jerome D. Green, 05.09.1935; 1 Brief an die Rockefeller Foundation (Paris) von Julian Gumperz, 01.09.1935; 1 Brief von Julian Gumperz an Arthur Surveyer, 24.05.1935; 3 Briefe von der William M. Mortimer Company (New York) and Max Horkheimer, 1934; 4 Briefe von Julian Gumperz an die William M. Mortimer Company (New York), 1934; 2 Briefe zwischen Robert S. Lynd und Julian Gumperz, Juli 1934; 2 Briefe zwischen Julian Gumperz und Frederick Pollock, 1934; 1 Brief an Birchman & Molloy von Julian Gumperz, 16.05.1934; 1 Brief von Julian Gumperz an A. Flexner, 14.05.1934; 1 Brief an die United States Lines (New York) von Julian Gumperz, 10.05.1934; 24 Briefe zwischen Julian Gumperz und Taylor Mitchell (Capron & Marsh, New York), 1934 - 1935; 1 Brief von The Brookings Institution (Washington D.C.) an Julian Gumperz, 11.07.1934;

Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: Worldwide emergence

Infections caused by community-acquired (CA)-methicillin-resistant Staphylococcus aureus (MRSA) have been reported worldwide. We assessed whether any common genetic markers existed among 117 CA-MRSA isolates from the United States, France, Switzerland, Australia, New Zealand, and Western Samoa by performing polymerase chain reaction for 24 virulence factors and the methicillin-resistance determinant. The genetic background of the strain was analyzed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent. PFGE and MLST analysis indicated distinct genetic backgrounds associated with each geographic origin, although predominantly restricted to the agr3 background. Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA.

Non-positivity of Groenewold operators

A central feature in the Hilbert space formulation of classical mechanics is the quantisation of classical Lionville densities, leading to what may be termed Groenewold operators. We investigate the spectra of the Groenewold operators that correspond to Gaussian and to certain uniform Lionville densities. We show that when the classical coordinate-momentum uncertainty product falls below Heisenberg's limit, the Groenewold operators in the Gaussian case develop negative eigenvalues and eigenvalues larger than 1. However, in the uniform case, negative eigenvalues are shown to persist for arbitrarily large values of the classical uncertainty product.

Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin

Mannose-binding type 1 pili are important virulence factors for the establishment of Escherichia coli urinary tract infections (UTIs). These infections are initiated by adhesion of uropathogenic E. coli to uroplakin receptors in the uroepithelium via the FimH adhesin located at the tips of type 1 pili. Blocking of bacterial adhesion is able to prevent infection. Here, we provide for the first time binding data of the molecular events underlying type 1 fimbrial adherence, by crystallographic analyses of the FimH receptor binding domains from a uropathogenic and a K-12 strain, and affinity measurements with mannose, common mono- and disaccharides, and a series of alkyl and aryl mannosides. Our results illustrate that the lectin domain of the FimH adhesin is a stable and functional entity and that an exogenous butyl alpha- D-mannoside, bound in the crystal structures, exhibits a significantly better affinity for FimH (K-d = 0.15 muM) than mannose (K-d = 2.3 muM). Exploration of the binding affinities of alpha-D-mannosides with longer alkyl tails revealed affinities up to 5 nM. Aryl mannosides and fructose can also bind with high affinities to the FimH lectin domain, with a 100-fold improvement and 15-fold reduction in affinity, respectively, compared with mannose. Taken together, these relative FimH affinities correlate exceptionally well with the relative concentrations of the same glycans needed for the inhibition of adherence of type 1 piliated E. coli. We foresee that our findings will spark new ideas and initiatives for the development of UTI vaccines and anti-adhesive drugs to prevent anticipated and recurrent UTIs.