[Archives de la Parole]. , La parabole de l'enfant prodigue : récit (dravidien, malayālam, province de Madras) / [Sir George Grierson], éd. ; Linguistic survey of India ; [C.K. Gopalamenon], voix

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. État du Kérala. Région du Malabar]

Maladies inflammatoires de l'intestin [Main therapeutic advances in IBD in 2007].

In 2008 three biological agents against TNFalpha will be available. The combination of infliximab with azathioprine is no longer recommended, as hepatosplenic lymphomas with a particularly bad prognosis have been associated with this combined therapy. Regular maintenance therapy with infliximab is as effective in preventing the development of anti-infliximab antibodies as co-administration of this anti-TNFalpha agent with an immunomodulator. The benefit of regular maintenance therapy is probably linked to the presence of residual trough levels of infliximab between perfusions.

[Archives de la Parole]. , L'histoire de l'enfant prodigue [i.e. La |parabole de l'enfant prodigue] : récit (dravidien, canara, province de Madras) / [Sir George Grierson], éd. ; Linguistic survey of India ; [H. Venketashamurthy], voix

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. Etat du Karnataka. Mysore]

[Archives de la Parole]. , La parabole de l'enfant prodigue : récit (dravidien, canara, province de Madras) / [Sir George Grierson], éd. ; Linguistic survey of India ; [D. Narayana Batt], voix

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. Etat du Karnara]

The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy.

The regulation of the immune system is controlled by many cell surface receptors. A prominent representative is the 'molecular switch' HVEM (herpes virus entry mediator) that can activate either proinflammatory or inhibitory signaling pathways. HVEM ligands belong to two distinct families: the TNF-related cytokines LIGHT and lymphotoxin-α, and the Ig-related membrane proteins BTLA and CD160. HVEM and its ligands have been involved in the pathogenesis of various autoimmune and inflammatory diseases, but recent reports indicate that this network may also be involved in tumor progression and resistance to immune response. Here we summarize the recent advances made regarding the knowledge on HVEM and its ligands in cancer cells, and their potential roles in tumor progression and escape to immune responses. Blockade or enhancement of these pathways may help improving cancer therapy.

[Archives de la Parole]. , La parabole de l'enfant prodigue : Dravidien, Tamoul (groupe de l'Inde péninsulaire, Province de Madras) / [Sir George Grierson], éd. ; Linguistic survey of India ; [Krishnamacharya Ranga Nath], voix

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. Etat du Tamil Nadu. Thanjavur]

[Archives de la Parole]. , La parabole de l'enfant prodigue : dravidien, malayālam, province de Madras / [Sir George Grierson], éd. ; Linguistic survey of India ; [K.K. Achyutan], voix

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. État du Kérala. Kochi]

[Archives de la Parole]. , Chant populaire : indo-aryen, bhīlī marāṭhī / [Sir George Grierson], éd. ; Linguistic survey of India ; [Paulat Sakharam], voix

[Traditions. Asie. Inde. État du Maharashtra. Dhule]

[Archives de la Parole]. , Chant populaire d'étudiants : gujarātī (dial. bhīlī), indo-aryen / [Sir George Grierson], éd. ; Linguistic survey of India ; [Lala Teja et Amthabai Dhanjabhai], choeur (hommes)

[Traditions. Asie. Inde. Présidence de Bombay. État du Gujarat. Ahmadabad]

[Archives de la Parole]. , Fable : gujarātī (dial. bhīlī), indo-aryen / [Sir George Grierson], éd. ; Linguistic survey of India ; [Lala Teja], voix

[Traditions. Asie. Inde. Présidence de Bombay. État du Gujarat. Ahmadabad]

[Archives de la Parole]. , A song in Kolami from Yeotmal (Berar) : Ghaddi Arkengchandure [i.e. Ghaddi ārkeng chāndure] / [Sir George Grierson], éd. ; Linguistic survey of India ; [Rakma Kōlām], voix

[Traditions. Asie. Inde. Province du Berar. Yavatmal]

CO-EXPRESSION OF GCDH AND OAT1 IN NEURONS AND PROXIMAL TUBULE CELLS

Tissue-specific expression studies of Glutaryl-CoA dehydrogenase (Gcdh) in adult rats revealed expression in the whole rat brain, almost exclusively in neurons, and surprisingly high expression in the juxtamedullar cortex of the kidney. The organic anion transporter 1 (OAT1) mediates basolateral uptake of glutarate derivatives from proximal tubule cells and contributes to their renal clearance. In brain, OAT1 is expressed at the choroid plexus, in neurons of cortex and hippocampus. We hypothesized that Gcdh and Oat1 are co-expressed in the same cells in kidney and brain and analyzed their mRNA expression by in situ hybridization on cryosections of adult rat brain, kidney and liver. In brain, Gcdh and Oat1 were found co-expressed in most neurons. Only the Purkinje neurons of the cerebellum were found to be Oat1 negative. In the kidney Gcdh and Oat1 are widely co-expressed with a specific high expression in proximal tubule cells. In conclusion there seems to be a functional coupling of Gcdh and Oat1 on a renal and neuronal level. Further studies are ongoing to confirm these findings in human tissues.

The emergence of biofuels and the co-movement between crude oil and agricultural prices

Biofuels are becoming an alternative to non-renewable energy sources but we know little about the economic mechanisms influencing their prices. This paper studies the interrelationships between the spot prices of oil and those of agricultural commodities used as biofuel feedstocks. Using daily data since 1988, we identify a co-movement after 2005 that does not appear for other food-related commodities and is not due to general economic variables. We also find traces of the co-movement in the prices of a large biofuel stock. The results amount to the first systematic piece of empirical evidence linking spot oil and agricultural markets via the emergence of biofuels.

Obésite, troubles alimentaires et groupe de parole à l'adolescence [Obesity, eating disorders and the group approach for adolescents].

About a third of obese adolescents also suffer from some kind of eating disorders which have to be recognized and included in the therapeutic frame. Besides this co-morbidity, most of these patients also require a psychological support. The group approach represents an adequate response to these problems, in providing a space for exchanges and an opportunity for mutual support. The group approach may even prove more beneficial than an individual treatment. Involving the parents too reinforces the improvement that adolescents can get from their participation in such groups.

Co-evolution between sociality and dispersal: The role of synergistic cooperative benefits.

Explaining the evolution of sociality is challenging because social individuals face disadvantages that must be balanced by intrinsic benefits of living in a group. One potential route towards the evolution of sociality may emerge from the avoidance of dispersal, which can be risky in some environments. Although early studies found that local competition may cancel the benefits of cooperation in viscous populations, subsequent studies have identified conditions, such as the presence of kin recognition or specific demographic conditions, under which altruism will still spread. Most of these studies assume that the costs of cooperating outweigh the direct benefits (strong altruism). In nature, however, many organisms gain synergistic benefits from group living, which may counterbalance even costly altruistic behaviours. Here, we use an individual based model to investigate how dispersal and social behaviour co-evolve when social behaviours result in synergistic benefits that counterbalance the relative cost of altruism to a greater extent than assumed in previous models. When the cost of cooperation is high, selection for sociality responds strongly to the cost of dispersal. In particular, cooperation can begin to spread in a population when higher cooperation levels become correlated with lower dispersal tendencies within individuals. In contrast, less costly social behaviours are less sensitive to the cost of dispersal. In line with previous studies, we find that mechanisms of global population control also affect this relationship: when whole patches (groups) go extinct each generation, selection favours a relatively high dispersal propensity, and social behaviours evolve only when they are not very costly. If random individuals within groups experience mortality each generation to maintain a global carrying capacity, on the other hand, social behaviours spread and dispersal is reduced, even when the latter is not costly.