Filmes de gelana e pectina reticuladas ionicamente para liberação colônica

O cólon tem sido explorado nas últimas décadas como sítio de liberação de fármacos. A goma gelana e a pectina são polissacarídeos hidrofílicos naturais promissores para a obtenção de sistemas de liberação cólon-específica de fármacos, uma vez que são degradados especificamente por enzimas produzidas pela microbiota deste órgão. Filmes poliméricos apresentam grande aplicação no revestimento de formas farmacêuticas sólidas e podem permitir o controle das taxas de liberação de fármacos e/ou seu direcionamento para um órgão específico. Além disso, modificações químicas como a reticulação iônica podem alterar propriedades físico-químicas como reduzir a hidrofilia do sistema. Neste trabalho foram obtidos e caracterizados filmes de goma gelana e pectina reticuladas ionicamente com cátion trivalente (Al3+). Os efeitos da concentração de polímeros, agente reticulante e plastificante (glicerol) utilizados na preparação das amostras foram avaliados a partir da caracterização das propriedades mecânicas, físicas e químicas dos filmes. A análise macroscópica revelou filmes flexíveis, homogêneos e translúcidos e a análise por microscopia eletrônica de varredura mostrou que a reticulação contribuiu para a formação de filmes com superfícies rugosas. Os baixos valores de transmissão de vapor d'água obtidos indicam a possibilidade de uma importante proteção contra a umidade. A absorção de líquido pH-dependente dos filmes foi demonstrada e a menor absorção de líquido em meio ácido deve garantir uma proteção da forma farmacêutica, quando em contato com o meio gástrico. Os filmes se mostraram bastante mucoadesivos, o que deve favorecer a retenção da forma farmacêutica no sítio alvo e as características mecânicas se mostraram favoráveis para a elaboração de filmes para revestimento de formas farmacêuticas sólidas

Diagnóstico da qualidade da água da microbacia do Córrego da Aldeia em Fernandópolis-SP

Pós-graduação em Engenharia Civil - FEIS

Análise do crescimento das empresas de base tecnológica no Brasil

Technology-Based Firms (TBFs) are companies with intensive innovation dynamics based on technical competences, and for which high growth rates are expected. Nevertheless, even in developed countries, the evidence suggests that significantly high growth rates are more the exception than the rule. In Brazil, most studies on TBFs focus on factors that limit their success, such as managerial experience and capital availability. Based on extensive field research and on a reliable enterprise growth rate indicator, this article aims to evaluate the expansion of those firms, analyzing its relation to key elements such as degree of consolidation, market insertion, and public policy support. We found a growth rate which, although widely varied amongst firms, was significant and was not directly related to the amount of public policy support.

Cálculo e implementação do índice de Desenvolvimento da Gestão Municipal (IDGM) no município de Itabaiana/Se

The scarcity of resources which frequently confronts the State, coupled with demands to provide assistance to a needy population, requires that public administrators formulate efficient and effective policies to pursue its goals. It is fundamental that such policies are based on solid information of existing conditions. As such, the availability of reliable and updated socio-economic indicators is an important tool on which to fundament public policies. The present paper aims to present a Municipal Development Index – Municipal Management Development Index (IDGM) – calculated for the city of Itabaiana/SE, and is divided in two sections. The first discusses the concept of economic development and the evolution of measurement frameworks, with emphasis on the IHD and some of its limitations. The second section describes an estimated IDGM for the city of Itabaiana, as well as its methodology, results, and a brief comparative analysis with four municipalities from the state of São Paulo. Itabaiana’s IDGM reached 849 points (the maximum is 1.000), which infers a good developmental condition.

Double-setting alpha-tricalcium phosphate cement provided with interconection channels in rabbits after enucleation: a potential implant for the anophthalmic socket

The purpose of this study was to evaluate the macroscopy and microstructure of a double setting alpha-tricalcium phosphate bone cement sphere provided with interconnection channels (alpha-TCP-i), as well as the integration of the implant with the rabbits' orbital tissue, through macroscopic analysis and histopathology. The external and internal surfaces of the alpha-TCP-i were evaluated macroscopically and by electron microscopy. Twelve New Zealand rabbits received 12mm implants of alpha-TCP-i following enucleation of the left eye. The clinical assessment was undertaken daily during the first 15 days, followed by fortnightly assessment until the end of the study period. For the morphological analysis, exenteration was performed in 3 animals per experimental period (15, 45, 90 and 180 days). The external and internal surfaces of the implant appeared solid, smooth and compact, with six channels which interconnected centrally. The micro-architecture was characterized by the formation of columns of hexagonal crystals. No signs of infection, exposure, dehiscence of sutures or extrusion of the implant were noted in any of the animals during the entire period of the study. The morphological evaluation demonstrated the presence of a thin capsule around the implant, from whence appeared fibro-vascular projections, which penetrated it through the interconnecting channels. In the first days after the insertion of the implant, an intense inflammatory reaction was noted. At 180 days, however, there were no signs of inflammation. The alpha-tricalcium phosphate cement implant was well tolerated in this rabbit model and appeared to be relatively inert with some fibrovascular ingrowth through the large channels.

Síntese, Caracterização Estrutural e Análise do Potencial Catalítico, para a Preparação de Biodiesel, de Niobatos Não Estequiométricos com Estrutura Tungstênio Bronze

Pós-graduação em Química - IBILCE

Nanozeólitas como suportes sólidos para imobilização enzimática: Síntese, caracterização de complexos nanozeólitas/enzimas e sua aplicação como catalisadores heterogêneos para produção de biodiesel via rota etílica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Comparison of imaging methods for diagnosis of renal tumors and their calcifications

Background: To establish the best methodology for diagnosis and management of patients with solid and complex renal masses by comparing the costs and benefits of different imaging methods and to improve differential diagnosis of these benign and malignant lesions, particularly by investigating tumour calcifications. Methods: We performed a prospective study on 31 patients with solid or complex masses by submitting them to Abdominal Ultrasonography (US), Doppler Ultrasonography of the renal mass (US Dop), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). Results: We found 28 patients with malignant and three with benign masses. Of the 28 malignant, 17 showed calcifications at CT; 16 central and one was of the pure peripheral curvilinear type (egg shell). Excretory Urography (IVP) had a significantly lower detection rate for central calcifications than both US and CT. Benign and malignant masses appeared as described in literature, with US, CT and MRI showing high sensitivity and specificity in renal tumor diagnosis. The exception was US Dop where we obtained lower sensitivity for the characterization of malignant tumor flow. Conclusions: In this series we were surprised to find that CT revealed central calcifications in 51.6% of patients, all with malignant lesions, while, literature reports a frequency of calcification in renal cell carcinoma between 8 and 22%, in studies using abdominal films and EU (IVP). This finding is of great importance when we consider that these calcifications occur particularly in malignant neoplasms. As a result of comparing these different imaging methods we have developed a better methodology for renal tumor investigation.

Anatomia do talo de Canoparmelia texana (Parmeliaceae, Ascomycota liquenizados)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise dinâmica em vigas compostas com amortecimento utilizando o método dos elementos espectrais e elementos finitos

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fibra para cães: efeitos sobre o processo de extrusão, digestibilidade, fermentação microbiana, tempo de retenção intestinal e palatabilidade de rações para cães

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avaliação laboratorial da cinomose canina: estudo retrospectivo de 25 casos no município de Araçatuba-SP

Canine Distemper is a contagious, severe and multisystemic disease caused by a virus from Morbillivírus genus. The virus is distributed worldwide and it presents a high lethality rate, affecting mainly dogs. The diagnosis is based on clinical signs associated with hematological fi ndings. The observation of Lentz bodies in erythrocytes and leukocytes is the defi nitive diagnosis for the disease. The aim of this work was to test the hypothesis that the hematological profi le in dogs positive for canine distemper differs according to blood cell type presenting Lentz bodies. For this purpose, 25 dogs positive for the disease were evaluated at the Veterinary Hospital “Luís Quintiliano de Oliveira” UNESP, Araçatuba city. The diagnosis was based on the observation of Lentz bodies in blood smears. Fromthe total, 64% of dogs presented anemia, 16% leucopenia and 12% leukocytosis. Lymphopenia occurred in 76% of dogs. Viral inclusions were observed solely in neutrophils (32%), lymphocytes (28%) and erythrocytes (12%). Concomitant observation occurred in lymphocytes and erythrocytes (4 %), in lymphocytes and neutrophils (12%), in neutrophils and monocytes (4%) and in neutrophils and erythrocytes (4%). In an isolated case Lentz bodies were observed simultaneously in neuthrophils, monocytes and lymphocytes. In conclusion, hematological profi le is not associated with the presence of viral inclusion in a particular cell type.

Associação entre a doença periodontal e doenças sistêmicas crônicas: revisão de literatura

Periodontal disease has been increasingly associated as a supporting factor, and even a precursor to some systemic diseases. Just aim of this paper was to analyze by reviewing the literature, the possible mechanisms involved in the etiopathogenesis of periodontal disease that are common to the current systemic diseases such as obesity, atherosclerosis, diabetes and rheumatoid arthritis. The articles were analyzed with in the publication period of the years 2006 to 2011 and were surveyed in the databases PubMed, LILACS and SciELO. Of a total of 907 articles found by searching the indices and their associations, were selected by inclusion criteria 93 articles. For the preparation of this literature review, only 24 articles were selected because they are based on inflammatory mechanisms, metabolic and infectious, where the considerations for the strongest associations in the literature. This literature review reinforces the association of periodontal disease with systemic diseases analyzed due to presence of inflammatory and immunological mechanisms and similar synergism betwen the two diseases, but some hypotheses still need further clarification. The professional should stick to recent discoveries associations to promote periodontal treatment in preventing the development of systemic diseases, as well as in maintaining the systemic health of patients already suffering from chronic systemic diseases.

Óleo funcional na dieta de vacas leiteiras

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Micropartículas de goma gelana revestidas com filmes de amido resistente/pectina como estratégia para administração oral de insulina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)