¿Por qué tuvo Molly que vivir en Gibraltar?

¿Por qué tuvo Molly que vivir en Gibraltar?

Sobre la obra de Juan Daniel Fullaondo ¿Por qué tuvo Molly que vivir en Gibraltar?

Sobre la obra de Juan Daniel Fullaondo ¿Por qué tuvo Molly que vivir en Gibraltar?

Tolerance of Arc repressor to multiple-alanine substitutions

Arc repressor mutants containing from three to 15 multiple-alanine substitutions have spectral properties expected for native Arc proteins, form heterodimers with wild-type Arc, denature cooperatively with Tms equal to or greater than wild type, and, in some cases, fold as much as 30-fold faster and unfold as much as 50-fold slower than wild type. Two of the mutants, containing a total of 14 different substitutions, also footprint operator DNA in vitro. The stability of some of the proteins with multiple-alanine mutations is significantly greater than that predicted from the sum of the single substitutions, suggesting that a subset of the wild-type residues in Arc may interact in an unfavorable fashion. Overall, these results show that almost half of the residues in Arc can be replaced by alanine en masse without compromising the ability of this small, homodimeric protein to fold into a stable, native-like structure.

Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch.

In studies of variants of the P(ant) promoter of bacteriophage P22, the Arc protein was found not only to slow the rate at which RNA polymerase forms open complexes but also to accelerate the rate at which the enzyme clears the promoter. These dual activities permit Arc, bound at a single operator subsite, to act as an activator or as a repressor of different promoter variants. For example, Arc activates a P(ant) variant for which promoter clearance is rate limiting in the presence and absence of Arc but represses a closely related variant for which open-complex formation becomes rate limiting in the presence of Arc. The acceleration of promoter clearance by Arc requires occupancy of the operator subsite proximal to the -35 region and is diminished when Arc bears a mutation in Arg-23, a residue that makes a DNA-backbone contact in the operator complex.

La política sobre Gibraltar del nuevo gobierno español

El nuevo gobierno español presidido por Mariano Rajoy ha vuelto a desarrollar una política consistente en el contencioso colonial de Gibraltar. No obstante el cambio de política tendrá que tener en cuenta que, con anterioridad, las políticas desarrolladas en los últimos treinta años, con la excepción de los gobiernos de José María Aznar, han permitido al Reino Unido consolidar unas posiciones que no eran ni son aceptables para los intereses nacionales españoles y rompen con la doctrina descolonizadora de Naciones Unidas y el tratado de Utrecht.

La pista de aterrizaje de Gibraltar y la base militar

La base militar de Gibraltar, que ha sido tradicionalmente utilizada por el Reino Unido, creció en importancia durante la Segunda Guerra Mundial y posteriormente durante la Guerra Fría. A partir del hundimiento de la Unión Soviética se reorganizaron sus funciones militares. La base militar sigue siendo importante. Es un activo ante circunstancias geopolíticas cambiantes que, como enseña la historia, no siempre son predecibles. La realidad fría no permite otro análisis. Desde esta perspectiva, el artículo muestra que la política española para la recuperación de la soberanía de Gibraltar ha sido profundamente inconsistente

El brexit británico, Gibraltar y la verja

El artículo trata de determinar las consecuencias que el brexit o salida del Reino Unido de la UE, o bien su permanencia, podrían tener en el cruce de la verja de Gibraltar.

Gibraltar, 1720 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Castellum Gibraltar in Andalusia situm cum celebri freto inter Europam et Africam : annexis circumjacentibus Portubus et Castellis, accurate designatum cura et sumptibus Tobiæ Conradi Lotter Geogr. Aug. Vindel. It was published by Seutter Matthaeus in 1720. The original sheet map contains 2 maps on 1 sheet. This dataset is georeferenced to the larger scale map entitled: Gibraltar. Scale [ca. 1:12,100]. Map in Latin, German, and French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, Universal Transverse Mercator (UTM) Zone 30N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, coastal features, and more. Relief shown pictorially. Depths shown by soundings. Includes indexes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Strait of Gibraltar, 1761 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte du détroit de Gibraltar, dressee au depost de cartes et plans de la marine pour le service des vaisseaux du roy par ordre de M. le Duc de Choiseuil, Ministre de la Guerre et de la Marine; par le S. Bellin Ingeniuer de la Marine et du Depost des Plans, Censeur Royal, de l'Academie de Marine, et de la Societé Royale de Londres. It was published by Minstre de la guerre et de la marine in 1761. Scale [ca 1:2,000]. Covers the Strait of Gibraltar region, including coasts of Gibraltar, Morocco, and Spain. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, Universal Transverse Mercator (UTM) Zone 30N projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features (including anchorage points), and more. Relief shown pictorially, depths by soundings. Includes also insets: Plan de Gibraltar [with index] -- Tables de marées qui regnent dans le détroit.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Gibraltar, 1756 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan géométral de Gibraltar : avec les nouveaux ouvrages de cette ville faits par les Anglois, les attaques des Espagnols commencées au mois de Fevrier 1727 et les lignes faites après la levée du siége par ordre du Roy Catholique Philippe V pour empécher la communication de Gibraltar d'avec l'Espagne, construit d'après plusieurs plans parle Chevalier de Beaurain Géographe Ordinaire du Roy. It was published by Le Chevalier de Beaurian in 1756. Scale [ca. 1:14,286]. Covers Gibraltar. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, UTM Zone 30N coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, coastal features, and more. Relief is shown by hachures; depths by soundings and shading. Includes index, text, and views: Vue de la Montagne de Gibraltar du côté d'Orient -- Vue de la ville et de la Montagne de Gibraltar du côté d'Occident. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Gibraltar, 1781 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan géometral de la ville et de la montagne de Gibraltar : nouvellement corrigé d'après les originaux anglais, par L. Denis, géographe et auteur du Conducteur Francais, 1781. It was published by chès Basset in [1781]. Scale [ca. 1:1,111]. Covers Gibraltar. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, UTM Zone 30N coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, ship routes of attack, built-up areas and selected buildings, fortification and defenses, ship lines of fire, and other places of military interest for the Siege of Gibraltar, 1779-1783, ground cover, and more. Relief is shown by hachures; depths shown by soundings. Includes index. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Gibraltar, 1739 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A new and exact plan of Gibraltar : with all its fortifications as they are at present. Showing the great strength and use of it &c., humbly inscribed to ye. Rt. Honble. the Earl of Portmore by H. Moll G. It was published by Thomas Salmon in 1739. Scale [ca. 1:7,700]. Covers Gibraltar. The image inside the map neatline is georeferenced to the surface of the earth and fit to the European Datum 1950, UTM Zone 30N coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, and more. Relief is shown by hachures and pictorially. Includes explanation, notes, and index. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Nagorno-Karabakh and the arc of crises on Europe's borders. EPC Policy Brief, 3 February 2016

For more than two decades, Azerbaijan and Armenia have been locked in a stalemate over the Nagorno-Karabakh. The protracted conflict remains the biggest impediment to security, stability and prosperity in the South Caucasus. The EU has put itself on the sidelines of the conflict resolution process, allowing the Organization for Security and Co-operation in Europe (OSCE) Minsk Group (MG), of which Russia, France and the US are co-chairs, to take centre stage. In this Policy Brief, Amanda Paul and Dennis Sammut argue that the EU should play a more active role in the conflict resolution process, taking the lead with innovative initiatives and using its soft power skills and experience. A recent review of the European Neighbourhood Policy recognises that protracted conflicts continue to hamper development in the region. This new approach now needs to be given substance, before the conflict further escalates and becomes another crisis on Europe’s border the already burdened Union cannot cope with.