824 resultados para Genomica Funcional
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Fisiopatologia em Clínica Médica - FMB
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Relação entre incapacidade funcional, amplitude de movimento e dor em indivíduos com e sem lombalgia
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Introduction: Low back pain is characterized as pain between the inferior margins of the ribs to the gluteal fold, reaching about 80% of the population throughout life. Its repercussions can affect the functionality of the subjects in their daily activities. The aim was to investigate whether a relation between symptoms of pain in the lumbar region with range of motion and functional disability. Methods: We interviewed 101 subjects with a mean age of 22.61 ± 4.06 years, these 50 participants were 51 low back pain and other complaints of back pain. OS subjects were assessed for pain by Visual Analogue Scale (VAS), mobility Lumbar Schöbber test (TS), flexibility for the Test Sit and Reach (TSA) and feature the Oswestry Disability Index (IOI). For data analysis we used GraphPad Prism 5, the significance level was set at p ≤ 0.05. Results: No significant differences were found for the comparison between the TSA of the subjects with and without pain (p = 0.25), nor to compare the performance of the TS for the subjects with and without pain (p = 0.18). Conclusion: It is concluded that in cases evaluated the range of motion has no significant link with the pain but the pain in turn directly influence the functionality of them.
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The influence of the environment on psychomotor development of children is evidenced in many studies. Many factors can threaten children’s development and hinder the children with regard to functional activities. Objective: The objective of this research was to investigate the possible effects of urban and rural environment on the functional performance of children under six years old. Methods: The study included 30 children divided into two groups, one group consisted of 15 children of both genres with a mean age of 44.13 ± 20.97 months, residing in urban area and another for 15 children, both sexes with a mean age of 44.33 ± 20.91 months, residing in rural areas. All were tested using functional Pediatric Evaluation of Disability Inventory (PEDI), which is based on an evaluation trial, conducted through structured interviews with those responsible for the child. This test outlines the functional profi le of children in three performance areas: self-care, mobility and social function, evaluated in three parts (functional skills, caregiver assistance and modifi cations to the environment). In this study we used the parts I (funcional skills) and II (caregiver assistance) in three areas: self-care, mobility and social function. The collected data were analyzed by means of the Mann - Whitney test, with the level of signifi cance at p ≤ 0.05. Results: The results show no signifi cant difference in the areas of self-care and mobility, both in relation to functional abilities when the caregiver assistance. In the area of social function, there was a lower performance of children living in rural areas, in functional abilities (p = 0.027) and caregiver assistance (p = 0.028). Conclusion: Based on this information, we can conclude that children who live in rural areas have a worse development of the social functions of children living in urban areas.
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Introduction: Parkinson’s disease (PD) is a chronic disease of the nervous system, characterized by degeneration of neurons in the mesencephalic substantia nigra, leading to a clinical state of rest tremor, bradykinesia, muscular rigidity and postural instability. Physical therapy seeks to act by slowing the progression of the disease and when done in a group and maintain and / or improving the motor skills of the individual, can provide psychosocial benefi ts. Objective: examine the infl uence of the physical therapy group in balance, functional mobility and quality of life of individuals with PD. Method: participated in this study 04 subjects were female, mean age 67.75 (± 9.5) years, with medical diagnosis of PD, stages 1 to 3 of the Hoehn & Yahr. Before starting treatment, subjects underwent an assessment of the balance (BBS), functional mobility (TUG) and the quality of life (PDQ-39).The treatment was performed in groups, for a period of 10 weeks, lasting 60 minutes each session twice a week, totaling 20 sessions of physiotherapy. Upon completion of the treatment period the subjects were again assessed for balance, functional mobility and quality of life. The data were analyzed using the Student t-test, with signifi cance level of 5% (p ≤ 0.05). Results: statistical analysis showed signifi cant differences in three variables: equilibrium (p = 0.010), functional mobility (p = 0.029) and quality of life (p = 0.004), after physiotherapy intervention. Conclusion: physiotherapy treatment was group provides better balance, functional mobility and quality of life of patients with PD.
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Introduction: Parkinson’s disease is a chronic disease of the nervous system that leads to a clinical picture of resting tremor, bradykinesia, muscular rigidity and postural instability. These symptoms, in turn, directly influence the functional independence of the individual. Objective: To analyze the influence of muscle strengthening on functional independence of individuals with Parkinson’s disease. Method: A total of ten subjects of both genders participated in this study. We evaluated the functional independence, strength of lower limbs, grip strength testing and 1 repetition maximum. After the evaluation was performed muscle building program for 12 weeks. Results: There was improvement of functional independence (p = 0.007) and lower limb strength (p = 0.01), as well as an increase in grip strength, both of the dominant hand (p = 0.007) and the non-dominant one (p = 0.02). Conclusion: The muscle strength improved the functional independence of individuals with PD.
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This research was aimed to survey depressive episodes, functional and cognitive decline of an elderly population residing nursing homes (NH) located at Marília, São Paulo, Brazil, and, from statistical analysis, verify the potential correlations between depressive episodes, functional and cognitive decline, amongst themselves and with the variables: age, gender and education. There were subject to the research 57 elders living in the NH, aged between 59 and 98 and both sexes. The following tools were used to collect data: Mini Mental State Exam (MMSE) to evaluate cognitive faculty, Barthel Index (BI) to evaluate cognitive faculty and Beck Depression Inventory (BDI).
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Introduction: Parkinson’s Disease (PD) is characterized by a set of four motor symptoms: tremor, rigidity, bradykinesia and postural instability. These defi cits may predispose individuals to limitations resulting from falls and their secondary consequences. Objective: To evaluate the functional balance and quality of life (QoL) in individuals with PD and determine whether there is correlation between performance on tests of balance with the QoL. Method: The project was referred to the Ethics Committee in Research of Universidade Estadual Paulista “Julio de Mesquita Filho” Campus de Marília and was approved under protocol number 1806/09. Participated in this study with individuals diagnosed with PD between levels one and four in the Hoen and Yahr scale. The subjects were evaluated according to functional balance and QoL, respectively by the instruments: Functional Balance Scale Berg (EEFB), Time Up and Go test (TUG), and Parkinson’s Disease Questionnaire-39 (PDQ-39). To perform the statistical analysis used the GraphPad Prism 5. To perform the correlation analysis for the variables passed normality by the Shapiro-Wilk. Since the variables were non-parametric test was used Spearman. During the analysis the statistical signifi cance level was considered p ≤ 0, 05. Results: We studied 25 individuals aged between 54 and 85 years (71.20 ± 8.50), time of diagnosis between one and 39 years (6.54 ± 7.71) disease. Moderate correlation was found between the EEFB with QoL (r =- 0.6), and TUG with QoL (r = 0.6836). Among the aspects of QoL balance showed a higher correlation with the domains “mobility” (TUG r = 0, 6768; EEFB r = -0.6155) and “Activities of daily living” (TUG r = 0, 7357, and EEFB r = -0.6521). Conclusion: Patients with Parkinson’s disease show defi cits in balance and QoL. The balance disorders have a high correlation among themselves and show how aspects of QoL.
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Introduction:The regular practice of physical activity is being used as a therapeutic resource to the elderly population, with the objective of reduction of the losses provoked by the growing old process. The home place (urban or rural) is still little explored in literature about your infl uence in the physical capacity of the elderly people. Objective: The aim of this study was to value and compare the quality of life, motion and functional capacity between physically active and sedentary elderly people, residents in the urban and rural area. Methods: Sixty people with age above 60 years old were valued, 20 physically active residents in the urban area (66,5 ± 4,32 years), 20 sedentary residents in the urban area (68,8± 7,24 years), 10 physically active residents in the rural area (64,4±2,46 years) and 10 sedentary residents in the rural area (68±5,78 years). It was realized the evaluation of the fl exibility (previous fl exon of the trunk), mobility (timed up and go test), a six-minute walk test and answered a quality of life’s questionnaire SF-36. To compare the results obtained by the two groups was used the Kruskal-Wallis test, and the signifi cant presence of the test was performed post hoc Newman-Keuls. The level of signifi cance used in statistical analysis was 5% (p<0,05).Results: It was observed that the physically active elderly people obtaine better performance on the six-minutes walk test. It wasn’t found difference in the mobility among the groups. In relation to the quality of life, the elderly residents in the rural area, were better in the component Vitally. In relation to the fl exibility the elderly residents in the urban area obtained the best results. So, we can conclude that the practice of physical activity realized by the volunteers contributed to a better functional capacity, observed by the biggest distance gone through on the walk test. The rural home place positively infl uenced the vitality control, while the fl exibility was worse presented in these elderly people.
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Indivíduos com Paralisia Cerebral apresentam desenvolvimento motor atípico, caracterizado por alterações posturais, de coordenação motora e de tônus muscular, que resulta em limitações no desempenho de atividades funcionais. Neste contexto destaca-se a prescrição e confecção de recursos de tecnologia assistiva com objetivo de maximizar as habilidades funcionais destas pessoas e prover sua inclusão social. Os indivíduos com paralisia cerebral, muitas vezes, têm dificuldade para a manutenção da dinâmica corporal, principalmente na postura sentada. O objetivo deste estudo foi o de confeccionar uma cadeira e mesa escolar adaptadas com material de baixo custo e verificar sua eficácia no desempenho grafomotor de uma criança com paralisia cerebral. O participante foi uma criança com diagnóstico de paralisia cerebral diplégica, do gênero masculino. A coleta e registro dos dados foram feitos em três momentos, com a criança posicionada no mobiliário adaptado, no mobiliário escolar comum e novamente no mobiliário adaptado, para se estabelecer a comparação. A análise de dados se deu por meio de testes estatísticos não paramétricos. Não houve significância estatística e foi verificada uma inconstância nos dados apresentados, já que não se pode afirmar ao certo qual mobiliário foi mais eficaz na realização da atividade proposta e nem se houve aprendizado motor com a sua repetição. Esse fato não invalida a adequação de mobiliário escolar ao aluno com paralisia cerebral, visto que este é um fator importante para favorecer o controle e estabilidade postural ao individuo, o que interfere na coordenação motora fina destes indivíduos, influenciando no seu desempenho em atividades escolares.
Desempenho funcional nas atividades de vida diária de crianças com Transtorno do Espectro do Autismo
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Nos últimos vinte anos, as novas formas de produção documental e as tecnologias de informação têm levado os arquivistas a repensarem seu papel na sociedade, assim como os princípios e conceitos arquivísticos promulgados no século XIX. Neste contexto, emergem, notadamente no Canadá, novas abordagens para a organização do conhecimento arquivístico contemporâneo, destacando-se, dentre elas, a Arquivística Funcional, ou Pós-Moderna. O presente artigo aborda a contribuição dessa nova corrente para a constituição de uma disciplina contemporânea, notadamente a partir dos estudos de seu precursor e disseminador, Terry Cook.