A discourse-theoretic perspective on the bioethical-legal framework of genetic counseling

The reflexive nature of reason and the unique relationship reason shares with autonomy in Kant's philosophy is the theoretical basis of this dissertation. The principle of respect for autonomy undergirds the two main legal and ethical tenets of genetic counseling, an emerging profession trying to accommodate the sweeping changes that have occurred in clinical genetics, clinical ethics, and case law applicable to medicine. These two tenets of the counseling profession, informed consent and nondirectiveness, both share a principlist interpretation of autonomy that I argue is flawed due to its connection to: instrumental forms of reasoning, empirical theories of action supporting rational choice, and a liberal paradigm of law. I offer an alternative bioethical-legal framework that is based in the Kantian tradition in law and ethics through the complex theories of Jurgen Habermas. Following Habermas's reconstruction of the mutually constituting notions of private and public autonomy, I will argue for a richer conceptualization of autonomy that can have significant implications for the legal and bioethical concepts supporting the profession of genetic counseling, and which can ultimately change counseling practice. ^

Ethical Consumption and Social Context: Experimental Evidence from Germany and the United States

This research examines the role of social context in ethical consumption, specifically, the extent to which anonymity and social control influence individuals' decisions to purchase organic and Fair Trade coffee. Our research design overcomes biases of prior research by combining framing and discrete choice experiments in a survey. We systematically vary coffee growing method (organic or not), import status (Fair Trade or not), flavor, and price across four social contexts that vary in degree of anonymity and normative social control. The social contexts are buying coffee online, in a large grocery store, in a small neighborhood shop, and for a meeting of a human rights group. Subjects comprise 1,103 German and American undergraduate students. We find that social context indeed influences subjects' ethical consumer decisions, especially in situations with low anonymity and high social control. In addition, gender, coffee buying, and subjective social norms trigger heterogeneity regarding stated ethical consumption and the effects of social context. These results suggest previous research has underestimated the relevance of social context for ethical consumption and overestimated altruistic motives of ethical consumers. Our study demonstrates the great potential of discrete choice experiments for the study of social action and decision making processes in sociology.

Tsava'ot ge'one Yis'rael : Hebrew ethical wills

selected and ed. by Israel Abrahams

Ethical procedures and patient consent differ in Europe.

BACKGROUND Research ethics approvals, procedures and requirements for institutional research ethics committees vary considerably by country and by type of organisation. OBJECTIVE To evaluate the requirements and procedures of research ethics committees, details of patient information and informed consent based on a multicentre European trial. DESIGN Survey of European hospitals participating in the prospective observational study on chronic postsurgical pain (euCPSP) using electronic questionnaires. SETTING Twenty-four hospitals in 11 European countries. PARTICIPANTS From the 24 hospitals, 23 local investigators responded; 23 answers were analysed. OUTCOME MEASURES Comparison of research ethics procedures and committee requirements from the perspective of clinical researchers. Comparison of the institutions' procedures regarding patient information and consent. Description of further details such as costs and the duration of the approval process. RESULTS The approval process lasted from less than 2 weeks up to more than 2 months with financial fees varying between 0 and 575 &OV0556;. In 20 hospitals, a patient information sheet of variable length (half page up to two pages) was provided. Requirements for patients' informed consent differed. Written informed consent was mandatory at 12, oral at 10 and no form of consent at one hospital. Details such as enough time for consideration, possibility for withdrawal and risks/benefits of participation were provided in 25 to 30% of the institutions. CONCLUSION There is a considerable variation in the administrative requirements for approval procedures by research ethics committees in Europe. This results in variation of the extent of information and consent procedures for the patients involved. TRIAL REGISTRATION euCPSP in Clinicaltrials.gov identifier: NCT01467102; PAIN-OUT in Clinicaltrials.gov identifier: NCT02083835.

Pre-clinical in vivo models for the screening of bone biomaterials for oral/craniofacial indications: focus on small-animal models.

Preclinical in vivo experimental studies are performed for evaluating proof-of-principle concepts, safety and possible unwanted reactions of candidate bone biomaterials before proceeding to clinical testing. Specifically, models involving small animals have been developed for screening bone biomaterials for their potential to enhance bone formation. No single model can completely recreate the anatomic, physiologic, biomechanic and functional environment of the human mouth and jaws. Relevant aspects regarding physiology, anatomy, dimensions and handling are discussed in this paper to elucidate the advantages and disadvantages of small-animal models. Model selection should be based not on the 'expertise' or capacities of the team, but rather on a scientifically solid rationale, and the animal model selected should reflect the question for which an answer is sought. The rationale for using heterotopic or orthotopic testing sites, and intraosseous, periosseous or extraskeletal defect models, is discussed. The paper also discusses the relevance of critical size defect modeling, with focus on calvarial defects in rodents. In addition, the rabbit sinus model and the capsule model in the rat mandible are presented and discussed in detail. All animal experiments should be designed with care and include sample-size and study-power calculations, thus allowing generation of meaningful data. Moreover, animal experiments are subject to ethical approval by the relevant authority. All procedures and the postoperative handling and care, including postoperative analgesics, should follow best practice.

Computed Ultrasound Tomography in Echo Mode for Imaging Speed of Sound Using Pulse-Echo Sonography: Proof of Principle

The limitations of diagnostic echo ultrasound have motivated research into novel modalities that complement ultrasound in a multimodal device. One promising candidate is speed of sound imaging, which has been found to reveal structural changes in diseased tissue. Transmission ultrasound tomography shows speed of sound spatially resolved, but is limited to the acoustically transparent breast. We present a novel method by which speed-of-sound imaging is possible using classic pulse-echo equipment, facilitating new clinical applications and the combination with state-of-the art diagnostic ultrasound. Pulse-echo images are reconstructed while scanning the tissue under various angles using transmit beam steering. Differences in average sound speed along different transmit directions are reflected in the local echo phase, which allows a 2-D reconstruction of the sound speed. In the present proof-of-principle study, we describe a contrast resolution of 0.6% of average sound speed and a spatial resolution of 1 mm (laterally) × 3 mm (axially), suitable for diagnostic applications.

Ethical considerations for a global concept of sustainable land use

The paper gives an overview of current land husbandry problems in different agro-ecological zones of the world. It then lists four ethical principles, conceived at the global level, needed to achieve sustainable land use (SLU). Finally, it develops guidelines which can be used to facilitate a more effective implementation and realization of SLU. In the year of the UN Conference on Environment and Development (UNCED), such recommendations are important for improving the competence of political and economic decision-makers in taking action at national and international levels.

Do Information, Price, or Morals Influence Ethical Consumption? A Natural Field Experiment and Customer Survey on the Purchase of Fair Trade Coffee

We address ethical consumption using a natural field experiment on the actual purchase of Fair Trade (FT) coffee in three supermarkets in Germany. Based on a quasi-experimental before-and-after design the effects of three different treatments – information, 20% price reduction, and a moral appeal – are analyzed. Sales data cover actual ethical purchase behavior and avoid problems of social desirability. But they offer only limited insights into the motivations of individual consumers. We therefore complemented the field experiment with a customer survey that allows us to contrast observed (ethical) buying behavior with self-reported FT consumption. Results from the experiment suggest that only the price reduction had the expected positive and statistically significant effect on FT consumption.

New Sites, New Challenges? Ethical and Methodological Questions in the Context of Research on Migration Exclusion

The challenges of research ethics and methodologies have been reflected on extensively, but – aside from the context of feminist methodologies – less so in relation to research on particular migration sites such as in transit, detention centres, at the borders or within migration administration. First attempts in this direction have been made (Düvell et al. 2010, Fresia et al. 2005, Riedner 2014, van Liempt/Bilger2009), however, more reflection and theorization is needed, considering the contested nature of these temporal and volatile sites. In this workshop, we thus aim at examining methodological as well as ethical questions that arise during field work: We attempt to reflect the power relations involved in the research process, the ethics of research design, the dissemination of research results, the question of gaining access to and – whenever necessary – staying in contact with our research subjects. How can we negotiate informed consent with subjects whose life is currently marked by transit and insecurity concerning their own future, and who are in an uncertain situation in which substantial information (legal, social, cultural etc.) is likely to be missing? How do we deal with the dilemma of possibly contributing to knowledge production that might facilitate removals and deportations in the future, considering that the reception of the results is not in the hands of the researchers? How do we deal with the anticipated as well as unexpected impacts of our research on social and political practice? Regarding fieldwork in state institutions, how do we negotiate the multiple loyalties we often find ourselves faced with as social researchers, both with the excluded migrants and with the authorities implementing the exclusions – two groupings considered to be opposite to each other (Lavanchy 2013)? Which different roles do researchers need to take on? The aim of our workshop is first and foremost to exchange experiences on fieldwork with others doing qualitative research on related topics and to consider its possible implications – including affective dimensions – for all participants involved in the research process: the migrants, the security staff of detention centres, its social workers, border police and bureaucrats and, last but not least, the researchers themselves. Furthermore, we generally wish to reflect upon the question of how best to conduct research in this contested field, applying an interdisciplinary perspective.

Mimesis en Aristóteles : Reconsideración de su significado y su función en el Corpus Aristotelicum

El punto de partida de la presente investigación sobre el significado y la función que la mimesis tiene en el pensamiento de Aristóteles está dado por la adopción de una perspectiva de estudio 'amplia', i.e. no restringida a la esfera de las artes miméticas y que atienda al vasto y diverso registro de usos del vocabulario mimético atestiguado en el Corpus Aristotelicum. La exégesis contemporánea -paradigmáticamente representada por Halliwell (2002)- acuerda en recortar la superficie textual de investigación al dominio de la Poética (especialmente, al de sus tres primeros capítulos) y en menor medida, al libro VIII de la Política. Aún cuando es innegable el valor que la Poética tiene en la reconstrucción de la significación aristotélica de mimesis, la consideración de otras obras y otros pasajes en los que el filósofo recurre al empleo de este vocabulario, v.gr. H.A., Mete., Phys., Met., permite comprender el lugar destacado que Aristóteles le otorga a la habilidad y a las artes miméticas en el marco general de su pensamiento. La reevaluación general del significado de esta familia de palabras en el Corpus se organiza en dos partes principales. La primera está dedicada al análisis de la habilidad y de las artes miméticas como formas de aprendizaje a partir de los empleos atestiguados en Poética y en Política VII-VIII. A pesar de no ofrecer en la Poética ni en ninguna otra parte del Corpus una definición del término, el análisis realizado en el primer capítulo de la tesis sobre los principales usos del vocabulario mimético en dicha obra, i.e. capítulos 1-3, 4, 9, 24 y 25, revela que la habilidad y las artes miméticas, en cuanto que derivan de ella, constituyen para Aristóteles formas más o menos complejas de aprendizaje por medio de la identificación de semejanzas. En el segundo capítulo se examina el valor pedagógico que en los dos últimos libros de la Política Aristóteles le reconoce a la mimesis, y la singularidad que le atribuye a la mimesis musical entre las artes miméticas. El carácter antropológico de la mimesis como habilidad primaria de adquisición de conocimientos, ligada al deseo humano de conocer, permite explicar la función ético-política que le otorga a la música y de manera plausible, a las restantes artes miméticas en el programa educativo utópico del Estado ideal. La segunda parte está consagrada a investigar el empleo del vocabulario mimético en el resto del Corpus, i.e. aquellos usos no referidos a las artes miméticas y que permiten esclarecer la significación general de este concepto, y comprender mejor su empleo en relación a ese grupo de artes. En el tercer capítulo se consideran diversos pasajes que revelan el valor didáctico y heurístico que dicho vocabulario tiene en el ámbito de la investigación natural. El cuarto capítulo responde a la exigencia metodológica según la cual, es preciso comprender la mimesis aristotélica a la luz de su historia efectual. El principio conforme al cual las artes imitan a la naturaleza ha sido el eje de la recepción de la mimesis aristotélica hasta el siglo XIX. Completamente ajeno al interés primariamente estético de la exégesis actual, el principio es visto como una amenaza que atenta contra la singularidad del arte. A pesar de esta actitud generalizada por parte de los estudios histórico-sistemáticos contemporáneos se rescata el valor de este principio pues, si bien es cierto que fue formulado por Aristóteles en relación a todas las artes (miméticas y no-miméticas), su aplicación al primer grupo permite elucidar cuál es la función de ellas respecto al fin que la naturaleza ha establecido para el hombre. Finalmente, el apéndice está dedicado a la consideración de la innegable actualidad que la mimesis aristotélica tiene en la reflexión filosófica sistemática sobre el arte.

Mimesis en Aristóteles : Reconsideración de su significado y su función en el Corpus Aristotelicum

El punto de partida de la presente investigación sobre el significado y la función que la mimesis tiene en el pensamiento de Aristóteles está dado por la adopción de una perspectiva de estudio 'amplia', i.e. no restringida a la esfera de las artes miméticas y que atienda al vasto y diverso registro de usos del vocabulario mimético atestiguado en el Corpus Aristotelicum. La exégesis contemporánea -paradigmáticamente representada por Halliwell (2002)- acuerda en recortar la superficie textual de investigación al dominio de la Poética (especialmente, al de sus tres primeros capítulos) y en menor medida, al libro VIII de la Política. Aún cuando es innegable el valor que la Poética tiene en la reconstrucción de la significación aristotélica de mimesis, la consideración de otras obras y otros pasajes en los que el filósofo recurre al empleo de este vocabulario, v.gr. H.A., Mete., Phys., Met., permite comprender el lugar destacado que Aristóteles le otorga a la habilidad y a las artes miméticas en el marco general de su pensamiento. La reevaluación general del significado de esta familia de palabras en el Corpus se organiza en dos partes principales. La primera está dedicada al análisis de la habilidad y de las artes miméticas como formas de aprendizaje a partir de los empleos atestiguados en Poética y en Política VII-VIII. A pesar de no ofrecer en la Poética ni en ninguna otra parte del Corpus una definición del término, el análisis realizado en el primer capítulo de la tesis sobre los principales usos del vocabulario mimético en dicha obra, i.e. capítulos 1-3, 4, 9, 24 y 25, revela que la habilidad y las artes miméticas, en cuanto que derivan de ella, constituyen para Aristóteles formas más o menos complejas de aprendizaje por medio de la identificación de semejanzas. En el segundo capítulo se examina el valor pedagógico que en los dos últimos libros de la Política Aristóteles le reconoce a la mimesis, y la singularidad que le atribuye a la mimesis musical entre las artes miméticas. El carácter antropológico de la mimesis como habilidad primaria de adquisición de conocimientos, ligada al deseo humano de conocer, permite explicar la función ético-política que le otorga a la música y de manera plausible, a las restantes artes miméticas en el programa educativo utópico del Estado ideal. La segunda parte está consagrada a investigar el empleo del vocabulario mimético en el resto del Corpus, i.e. aquellos usos no referidos a las artes miméticas y que permiten esclarecer la significación general de este concepto, y comprender mejor su empleo en relación a ese grupo de artes. En el tercer capítulo se consideran diversos pasajes que revelan el valor didáctico y heurístico que dicho vocabulario tiene en el ámbito de la investigación natural. El cuarto capítulo responde a la exigencia metodológica según la cual, es preciso comprender la mimesis aristotélica a la luz de su historia efectual. El principio conforme al cual las artes imitan a la naturaleza ha sido el eje de la recepción de la mimesis aristotélica hasta el siglo XIX. Completamente ajeno al interés primariamente estético de la exégesis actual, el principio es visto como una amenaza que atenta contra la singularidad del arte. A pesar de esta actitud generalizada por parte de los estudios histórico-sistemáticos contemporáneos se rescata el valor de este principio pues, si bien es cierto que fue formulado por Aristóteles en relación a todas las artes (miméticas y no-miméticas), su aplicación al primer grupo permite elucidar cuál es la función de ellas respecto al fin que la naturaleza ha establecido para el hombre. Finalmente, el apéndice está dedicado a la consideración de la innegable actualidad que la mimesis aristotélica tiene en la reflexión filosófica sistemática sobre el arte.

The shift of paradigm in the organizations like foundation of the style of ethical leadership

La presente investigación tiene por objeto analizar el cambio de paradigma en las organizaciones como fundamento del liderazgo ético desde una realidad postmoderna a fin de detectar la necesidad de un liderazgo ético en las organizaciones donde los líderes sean formadores de valores a través del modelaje directivo; es un estilo de liderazgo en el que la visión ética, sistémica e integradora son unas de las principales aptitudes que el líder ético ha de poner en la práctica. Se han desarrollado teorías de liderazgo centradas no tanto en los rasgos o comportamientos de los líderes, sino en la relación entre líder y sus seguidores