Antonii Nebrissensis, V. CL. grammatici, et regii chronographi Dictionarium redivivum, novissimé emendatum, ac novis ... accesionibus auctum, locupletatum : pars altera ... /

Mode of access: Internet.

Lettres portugaises. Nouv. éd., conforme à la Ire. (Paris, Cl. Barbin, 1669), avec une notice bibliographique sur ces lettres.

For further details see note under entry for ed. La Haye, 1682.

V. cl. Iacobi Lectii i. c. Orationes. Addita svnt in eivsdem viri clarissimi obitum conscripta epicedia.

Dedication signed: Georgius Remus.

Das Neroni Cl. Druso b. d. Stadt Mäntz vormahls aufgericht. Grab- u. bedächtnuss - Mahl...

Mode of access: Internet.

Fur pro tribunali. Examen dialogismi cui inscribitur fur praedestinatus. Accesserunt oratio de doctrina Neopelagiana habita Oxonii in Comitiis Julii IX. M. DC. LIV. Cl. V. G. Tuissii vita, et vindiciae à calumniis et sophismatis Francisci Annati Jesuita; et dissertatiuncula de novis actibus imminentibus sintne Deo ascribendi.

Mode of access: Internet.

Die Quellen von Cl. Brentanos "Grundung der Stadt Prag".

Thesis (doctoral)--Friedrich Wilhelms Universitat zu Berlin.

De Clitophontis & Leucippes amoribus libri VIII, ex bibliotheca Cl. Salmasii.

Title in Greek at head of t.-p.

CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors:a comparison of effects of adrenomedullin 22-52, CGRP 8-37 and BIBN4096BS

1. Adrenomedullin (AM) has two known receptors formed by the calcitonin receptor-like receptor (CL) and receptor activity-modifying protein (RAMP) 2 or 3: We report the effects of the antagonist fragments of human AM and CGRP (AM 22-52 and CGRP 8-37) in inhibiting AM at human (h), rat (r) and mixed species CL/RAMP2 and CL/RAMP3 receptors transiently expressed in Cos 7 cells or endogenously expressed as rCL/rRAMP2 complexes by Rat 2 and L6 cells. 2. AM 22-52 (10 μM) antagonised AM at all CL/RAMP2 complexes (apparent pA 2 values: 7.34±0.14 (hCL/hRAMP2), 7.28±0.06 (Rat2), 7.00±0.05 (L6), 6.25±0.17(rCL/hRAMP2)). CGRP 8-37 (10 μM) resembled AM 22-52 except on the rCL/hRAMP2 complex, where it did not antagonise AM (apparent PA 2 values: 7.04±0.13 (hCL/hRAMP2), 6.72±0.06 (Rat2), 7.03±0. 12 (L6)). 3. On CL/RAMP3 receptors, 10 μM CGRP 8-37 was an effective antagonist at all combinations (apparent pA 2 values: 6.96±0.08 (hCL/hRAMP3), 6.18±0.18 (rCL/rRAMP3), 6.48±0.20 (rCL/ hRAMP3)). However, 10 μm AM 22-52 only antagonised AM at the hCL/hRAMP3 receptor (apparent PA 2 6.73±0.14). 4. BIBN4096BS (10 μM) did not antagonise AM at any of the receptors. 5. Where investigated (all-rat and rat/human combinations), the agonist potency order on the CL/ RAMP3 receptor was AM∼βCGRP>αCGRP. 6. rRAMP3 showed three apparent polymorphisms, none of which altered its coding sequence. 7. This study shows that on CL/RAMP complexes, AM 22-52 has significant selectivity for the CL/ RAMP2 combination over the CL/RAMP3 combination. On the mixed species receptor, CGRP 8-37 showed the opposite selectivity. Thus, depending on the species, it is possible to discriminate pharmacologically between CL/RAMP2 and CL/RAMP3 AM receptors.

Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)

Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

The importance of Na(plus)-K(plus)-Cl- cotransport in nitrogen mustard induced cell death

The incubation of murine leukaemic L1210 cells in vitro for 4 hours (hr) with 10uM nitrogen mustard (HN2), a bifunctional alkylating agent, inhibited the influx of the potassium congener, 88rubidium+ ( 86Rb+) by the selective inhibition of the Na+-K+-CI- cotransporter. The aim of this project was to investigate the importance of this lesion in HN2-induced cytotoxicity. 86Rb+ uptake in human erythrocytes was inhibited by high concentrations of HN2 (2mM) and occurred in two phases.In the first hour both the Na+/K+ ATPase pump and the Na+-K+-CI- cotransporter were equally inhibited but after 2 hrs exposure to 2mM HN2, the Na+ -K+ -CI- cotransporter was significantly more inhibited than the Na+/K+ ATPase pump. In contrast, both potassium transport systems were equally inhibited in L1210 cells incubated for 10 minutes with 1mM HN2. The selective inhibition of the Na+-K+-CI- cotransporter, after a 3 hrs exposure to 10uM HN2, was not absolved by coincubation with 5ug/ml cycloheximide (CHX), an inhibitor of protein synthesis. Incubation of L1210 cells with concentrations of diuretics which completely inhibited Na+-K+-CI- cotransport did not enhance the cytotoxicity of either HN2 or its monofunctional analogue 2-chloroethyldimethylamine (Me-HN1). The incubation of L1210 cells with a twice strength Rosewell Park Memorial Institute 1640 media did not enhance the toxicity of HN2. An L1210 cell line (L1210FR) was prepared which was able to grow in toxic concentrations of furosemide and exhibited a similiar sensitivity to HN2 as parental L1210 cells. Treatment of L1210 cells with 10uM HN2 resulted in a decrease in cell volume which was concurrent with the inhibition of the Na+-K+-CI- cotransporter. This was not observed in L1210 cells treated with either 1 or O.SuM HN2. Thus, possible differences in the cell death, in terms of necrosis and apoptosis, induced by the different concentrations of HN2 was investigated. The cell cycle of L1210 cells appeared to be blocked non-specifically by 10uM HN2 and in S and G2/M by either 1 or 0.5uM HN2. There were no significant changes in the cytosolic calcium concentrations of L1210 cells for up to 48 hrs after exposure to the three concentrations of HN2. No protection against th_ toxic effects of HN2 was observed in L1210 cells incubated with 5ug/ml CHX for up to 6 hrs. Incubation for 12 or 18 hrs with a non-toxic concentration (5mM) of L-Azetidine-2- carboxylic acid (ACA) enhanced the toxicity of low concentrations (<0.5uM) of HN2.

Nucleoside diphosphate kinase--a component of the [Na+1]- and [Cl-]-sensitive phosphorylation cascade in human and murine airway epithelium

We have shown that proteins within apically enriched fractions of human nasal respiratory epithelium vary their phosphohistidine content with ambient [Cl-] and other anion concentrations. This membrane-delimited phosphorylation cascade includes a multifunctional protein histidine kinase - nucleoside diphosphate kinase (NDPK). NDPK is itself a cascade component in both human and ovine airway, the self-phosphorylation of which is inhibited selectively by [Na+] in the presence of ATP (but not GTP). These findings led us to propose the existence of a dual anion-/cation-controlled phosphorylation-based "sensor" bound to the apical membrane. The present study showed that this cascade uses ATP to phosphorylate a group of proteins above 45 kDa (p45-group, identities unknown). Additionally, the Cl- dependence of ATP (but not GTP) phosphorylation is conditional on phosphatase activity and that interactions exist between the ATP- and GTP-phosphorylated components of the cascade under Cl--free conditions. As a prelude to studies in cystic fibrosis (CF) mice, we showed in the present study that NDPK is present and functionally active in normal murine airway. Since NDPK is essential for UTP synthesis and regulates fetal gut development, G proteins, K+channels, neutrophil-mediated inflammation and pancreatic secretion, the presence of ion-regulated NDPK protein in mouse airway epithelium might aid understanding of the pathogenesis of CF.

Energetikai célú fafajták termőhelyi alkalmassága Soroksáron

A fafajok megválasztása döntő jelentőségű az energiatermelő faültetvény tervezésénél, mert csak a termőhelynek megfelelő, gyorsan növő, nagy produkciójú fafajok és fajták jöhetnek számításba. A fajta és termőhelyi kérdések tisztázása érdekében 2011 tavaszán a tangazdaság soroksári területén mintegy 1500 m2-en kísérleti ültetvényt hoztunk létre 5 fűz és 9 nyárfajtával, ill. egyéb kontroll fajtákkal. Vizsgáltuk ezek növekedési erélyét valamint a termőhely talajtani és klimatikus adottságait, továbbá a technológiát és hatékonyságot.

Kaméleonok a tárgyalóasztalnál - A viselkedés stratégiai célú utánzásának hatása a tárgyalás eredményességére (Chameleons at the barganing table)

A tanulmány a rapport (összhang) jelenségét járja körül, bemutatva, hogyan, milyen feltételek mellett épül ki természetes módon, milyen előnyöket jelentett az evolúció folyamán, és milyen hasznot jelenthet napjainkban a tárgyalások során a partnerek számára. Rámutat arra is, hogy az összhang „mesterséges úton” is létrehozható, az interakciós partner viselkedésének tudatos utánzása által. A tudatos utánzás során az összhang valamennyi előnye megmarad a felek számára, és az utánzó fél úgy jut többletnyereséghez, hogy partnere nyereségét is növeli. A tanulmány elsősorban olyan szociálpszichológiai kísérleteket mutat be, amelyek tárgyalási szituációkra épülnek, és amelyekből hasznos gyakorlati következtetések vonhatók le a mindennapi tárgyalásokra vonatkozóan. ________ The benefit of the strategic behavioral mimicry on the efficiency of the negotiation. The paper focuses on the phenomenon of „rapport”, examining how and under what conditions it developes in a natural way, what benefits it had during the course of human evolution and what advantages it can hold nowadays for negotiating parties. The paper also points out that rapport can be established in an „artificial way”, by conscious imitation the behavior of interaction partners. During this conscious behavioral mimicry, all benefits of the rapport are reserved for the parties where the mimicking party gains extra benefits while increasing the benefits of the other party as well. The study presents certain social psychological experiments built around bargaining situations where useful practical conclusions can be drawn for everyday negotiating practices.