The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis

The purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P < 0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intra- and peritumoral regions was observed. Scarce CCL19+ and CCL21+ cells were also noted in metastatic and non-metastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC. © 2012 International Society of Oncology and BioMarkers (ISOBM).

Avaliação do uso de imobili zação externa após descompressão e fusão cervical por via anterior. Revisão Sistemática

This study aims to evaluate safety and effectiveness of the use of orthesis in postoperative degenerative disorders of the cervical spine. Although widely used, there are not defined criteria for the use of cervical collars, and their importance on cervical arthrodesis. A systematic literature review was undertaken and a multicentre controlled clinical trial comprising 32 specialized services, with a total of 257 patients who met the inclusion criteria of the review. Clinical and radiographic outcomes were compared in post surgical patients that used or not rigid cervical collar during 6 to 12 weeks after surgery. The evidence available on literature, although weak, suggests that cervical collar decreases the clinical scores in first weeks after surgery. Furthermore, it does not alter the rate of fusion when used concomitantly with plaque and screws through anterior access in cervical degenerative diseases on a single anatomical level.

Randomized controlled clinical trial evaluating connective tissue graft plus resin-modified glass ionomer restoration for the treatment of gingival recession associated with non-carious cervical lesion: 2-year follow-up

Background: The aim of this clinical study is to evaluate the 2-year term results of gingival recession (GR) associated with non-carious cervical lesions (NCCLs) treated by connective tissue graft (CTG) alone or in combination with a resin-modified glass ionomer restoration (CTG+R). Methods: Thirty-six patients with Miller Class I buccal GR associated with NCCLs completed the follow-up. The defects were randomly assigned to receive either CTG or CTG+R. Bleeding on probing (BOP), probing depth (PD), relative GR, clinical attachment level (CAL), and cervical lesion height coverage were measured at baseline, 6 months, 1 year, and 2 years after treatment. Results: Both groups showed statistically significant gains in CAL and soft-tissue coverage. The differences between groups were not statistically significant in BOP, PD, relative GR, or CAL after 2 years. Cervical lesion height coverage was 79.31% ± 18.51% for CTG and 71.95% ± 13.25% for CTG+R (P >0.05). Estimated root coverage was 91.56% ± 11.74% for CTG and 93.29% ± 7.97% for CTG+R (P ≥0.05). Conclusions: Within the limits of the present study, it can be concluded that both procedures provide comparable soft tissue coverage after 2 years of follow-up.

Aspectos clínicos e radiográficos da coluna cervical de bezerros submetidos a Prova do Laço

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da atividade apoptótica de substância pura isolada de Cryptocarya mandioccanna em células de carcinoma cervical imortalizadas pelo papilomavirus humano (HPV)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Síntese e caracterização de nanopartículas magnéticas de óxido de ferro para aplicações biomédicas – um estudo citotóxico em linhagem celular de carcinoma cervical humano (células HeLa)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Neoplasia intra-epitelial cervical em mulheres soro-positivas para o vírus da imunodeficiência humana

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Avaliação do bloqueio paravertebral cervical com ropivacaína em cães anestesiados pelo isofluorano e submetidos à osteossíntese radio-ulnar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da anestesia paravertebral cervical no bloqueio anestésico local do membro torácico em cães

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Métodos fotográficos para diagnóstico do padrão esquelético facial e avaliação da postura crânio-cervical

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Perfil de citocinas no soro e na secreção cervical de mulheres com lesão intraepitelial de baixo grau, lesão intraepitelial de alto grau e carcinoma epidermóide invasor

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo da pressão plantar em indivíduos com e sem dor temporomandibular antes e depois de uma intervenção fisioterapêutica manual na coluna cervical

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comparação da adaptação cervical de estruturas metálicas para metalo-cerâmica obtidas através de técnica de fundição rápida e convencional, utilizando três revestimentos comerciais

Pós-graduação em Odontologia - FOA

Avaliação das discrepâncias marginal vertical e interna de coroas totais cerâmicas confeccionadas por um sistema CAD/CAM, variando o término cervical

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Técnica experimental para inserção de parafuso no processo articular da coluna cervical inferior

Pós-graduação em Bases Gerais da Cirurgia - FMB