Executive Order Number Sixty Two, January 9, 1998

Rescinds Executive Order #54 and replaces it with a new team called the Primary Iowa Harzard Mitigation Team to coordinate state response to natural and technological disaters.

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

The paracaspase MALT1 is pivotal in antigen receptor-mediated lymphocyte activation and lymphomagenesis. MALT1 contains a caspase-like domain, but it is unknown whether this domain is proteolytically active. Here we report that MALT1 had arginine-directed proteolytic activity that was activated after T cell stimulation, and we identify the signaling protein Bcl-10 as a MALT1 substrate. Processing of Bcl-10 after Arg228 was required for T cell receptor-induced cell adhesion to fibronectin. In contrast, MALT1 activity but not Bcl-10 cleavage was essential for optimal activation of transcription factor NF-kappaB and production of interleukin 2. Thus, the proteolytic activity of MALT1 is central to T cell activation, which suggests a possible target for the development of immunomodulatory or anticancer drugs

Hina 5.9.1944

Kirje

Hina 11.9.1944

Kirje

Kansanedustaja Pekka Vilmi 9/6 1964

Kirje 9.6.1964

Statuta honorandae Nationis gallicanae recognita et reformata, senatus auctoritate confirmata die 9 augusti 1662. de novo edita...

[Acte. 1662-08-09]

Suomen Voimisteluliiton Puheenjohtaja 9/9 1960

Kirje

Hina 6.9.1942

Kirje

Rouva Anna-Liisa Vaurola 18/9 1973

Kirje 18.9.1973

Maisteri Raoul Palmgren 15/9 1960

Kirje 15.9.1960