Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes

Bifunctional chiral primary amine 8 containing an (S,S)-trans-cyclohexane-1,2-diamine scaffold and a 2-benzimidazole unit is used as a general organocatalyst for the Michael addition of α,α-branched aldehydes to nitroalkenes and maleimides. The reactions take place, with 20 mol % of catalyst in dichloromethane at rt for nitroalkenes and with 15 mol % catalyst loading in toluene at 10 °C for maleimides, in good yields and enantioselectivities. DFT calculations demonstrate the bifunctional character of this organocatalyst activating the aldehyde by enamine formation and the Michael acceptor by double hydrogen bonding.

Katalog der Astronomischen Gesellschaft. Katalog der Sterne bis zur neunten Grösze zwischen 2⁰ und 23⁰ südlicher Deklination für das Äquinoktium 1900 ...

Each vol. has also special t.-p.

Geschichte des k. und k. Dragoner-Regiments Graf Paar Nr. 2 : von seiner Errichtung bis zur Gegenwart, 1672-1891.

Mode of access: Internet.

Schlesiens Landesvertretung und Landeshaushalt von ihren Anfängen bis zur neuesten Zeit. Aus Anlass des 60-jährigen Regierungs-Jubiläums vom 2. Dezember 1908 Sr. Majastät des Kaisers Franz Josef I. hrsg. vom Schlesischen Landesausschusse. Unter Mitwirkung der schlesischen Landes-Ämter und Anstalten bearb. und redigiert von Karl Berthold.

I. T. Landesvertretung -- II. T. Landeshaushalt.

Geschichte der neuern Philosophie von Bacon von Verulam bis Benedict Spinoza.; Darstellung, Entwichlung und Kritik der Leibnitz'schen Philosophie. 2 vol.

Mode of access: Internet.

Allgemeine deutsche bibliothek ... Anhang zu dem fünf und zwanzigsten bis sechs und dreyssigsten bande ... Enthaltend: 1) Die anzeigen der neuen bücher von 1774 bis 1777, und einige von 1778 ... 2) Vollständige doppelte register ...

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Allgemeine deutsche bibliothek ... Anhang zu dem drey und funfzigsten bande ... Enthaltend: 1) Die anzeigen der neuen bücher von 1782 bis 1787 ... 2) Vollständige doppelte register ...

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Catalog der Astronomischen Gesellschaft. Erste Abtheilung. Catalog der Sterne bis zur neunten Grösse zwischen 80⁰ nördlicher und 2⁰ südlicher Declination für das Aequinoctium 1875 ...

Title varies: 2. Stück, "Katalog der Astronomischen Gesellschaft."

Preussen im Kampfe gegen die franzosische Revolution bis zur zweiten Teilung Polens : I. Abschnitt: Kapitel 1 und 2.

Thesis (doctoral)--Friedrich-Wilhelms-Universitat zu Berlin.

Die modulargleichungen der galois'schen moduln der 2. bis 5. st...

Thesis (doctoral)--

Fol. 2 a bis 54 b

Aus der Sammlung des Leo Baeck Institute, digitalisiert in Kooperation mit dem Center for Jewish History, NY

Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia

Several linkage studies across multiple population groups provide convergent support for a susceptibility locus for schizophrenia - and, more recently, for bipolar disorder - on chromosome 6q13-q26. We genotyped 192 European-ancestry and African American (AA) pedigrees with schizophrenia from samples that previously showed linkage evidence to 6q13-q26, focusing on the MOXD1-STX7-TRARs gene cluster at 6q23.2, which contains a number of prime candidate genes for schizophrenia. Thirty-one screening single-nucleotide polymorphisms (SNPs) were selected, providing a minimum coverage of at least 1 SNP/20 kb. The association observed with rs4305745 (P = .0014) within the TRAR4 (trace amine receptor 4) gene remained significant after correction for multiple testing. Evidence for association was proportionally stronger in the smaller AA sample. We performed database searches and sequenced genomic DNA in a 30-proband subsample to obtain a high-density map of 23 SNPs spanning 21.6 kb of this gene. Single-SNP analyses and also haplotype analyses revealed that rs4305745 and/or two other polymorphisms in perfect linkage disequilibrium (LD) with rs4305745 appear to be the most likely variants underlying the association of the TRAR4 region with schizophrenia. Comparative genomic analyses further revealed that rs4305745 and/or the associated polymorphisms in complete LD with rs4305745 could potentially affect gene expression. Moreover, RT-PCR studies of various human tissues, including brain, confirm that TRAR4 is preferentially expressed in those brain regions that have been implicated in the pathophysiology of schizophrenia. These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples.

Observation of a 331 K (58 °C) spin transition for bis[hydrotris(1,2,4-triazol-1-yl)borate]iron(II) by variable temperature infrared spectroscopy and magnetic susceptibility measurements

Fe{HB(CHN)} is observed by variable temperature infrared and magnetic studies to have a spin transition between the low spin S = 0 and high spin S = 2 states at 331 K (58 °C) with thermal hysteresis of ~1.5 K. Changes in the triazole ligand IR absorptions demonstrate that distant non-metal-ligand vibrations are altered upon the change in electronic structure associated with the spin-crossover can be used to monitor the the spin-crossover transition.