991 resultados para Bankruptcy – Chapter 11
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Al maig de 2001, el Parlament Europeu i el Consell aprovaven la Directiva relativa a l'harmonització de determinats aspectes dels drets d'autor i drets afins als drets d'autor en la societat de la informació. L'aprovació d'aquest text culminava un llarg - i difícil - procés els orígens del qual hem de buscar en el Llibre Verd sobre drets d'autor i els drets afins en la Societat de la Informació aparegut el 1995.
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Les 11 et 16 mai 1968, le Premier ministre français Georges Pompidou prononce deux allocutions de crise qui ont échappé à la critique. La présente étude propose de rendre compte de leur dynamique argumentative et rhétorique à partir d'une analyse textuelle des discours politiques. Il s'agit de considérer la manière dont l'orateur construit et articule différents énoncés, les ressources qu'il exploite pour s'inscrire dans son discours et donner une place à ses allocutaires ou encore les différents procédés qui lui permettent de construire et de blâmer le tiers perturbateur pour défendre la cohésion nationale. Plus généralement, l'analyse, qui respecte le caractère séquentiel des deux discours et les considère successivement, rend compte des différentes ressources langagières que Pompidou exploite pour schématiser le monde et inviter ses allocutaires au calme. Cette étude s'adresse à toute personne intéressée par l'argumentation, la rhétorique et l'analyse linguistique du discours politique.
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Fichas combinables entre sí por días de la semana, divididas en dos bloques: Desayuno-Comida y Merienda-Cena
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Kinetoplastid membrane protein-11 (KMP-11), a protein present in all kinetoplastid protozoa, is considered a potential candidate for a leishmaniasis vaccine. A suitable leishmaniasis vaccine candidate molecule must be expressed in amastigotes, the infective stage for mammals. However, the expression of KMP-11 in Leishmania amastigotes has been a subject of controversy. We evaluated the expression of this molecule in logarithmic and stationary growth phase promastigotes, as well as in amastigotes, of Leishmania amazonensis by immunoblotting, flow cytometry and immunocytochemistry, using a monoclonal antibody against KMP-11. We found that KMP-11 is present in promastigotes and amastigotes. In both stages, the protein was found in association with membrane structures (at the cell surface, flagellar pocket and intracellular vesicles). More importantly, its surface expression is higher in amastigotes than in promastigotes and increases during metacyclogenesis. The increased expression of KMP-11 in metacyclic promastigotes, and especially in amastigotes, indicates a role for this molecule in the parasite relationship with the mammalian host. The presence of this molecule in amastigotes is consistent with the previously demonstrated immunoprotective capacity of vaccine prototypes based on the KMP-11-coding gene and the presence of humoral and cellular immune responses to KMP-11 in Leishmania-infected humans and animals.
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In everyday debates on topics such as cultural differences, it seems relevant to analyze not only institutional conversations or speeches, but also mass-media communications. The way the media portray social events contributes to the construction of our categories of explanation of the world. The main purpose of this research is to analyze the representations of the Arabs before and after September 11, 2001 in the Italian and U.S. press. Results show that in Italy articles mainly focus on contrasting illegal immigration and on the consequent political and legislative decisions. Instead, U.S. press is focused on enhancing the sense of ingroup belonging, relying on the sense of threat of the Arabs to Western culture.
Resumo:
In Leishmania amazonensis, kinetoplastid membrane protein-11 (KMP-11) expression increases during metacyclogenesis and is higher in amastigotes than in promastigotes, suggesting a role for this protein in the infection of the mammalian host. We show that the addition of KMP-11 exacerbates L. amazonensis infection in peritoneal macrophages from BALB/c mice by increasing interleukin (IL)-10 secretion and arginase activity while reducing nitric oxide (NO) production. The doses of KMP-11, the IL-10 levels and the intracellular amastigote loads were strongly, positively and significantly correlated. The increase in parasite load induced by KMP-11 was inhibited by anti-KMP-11 or anti-IL-10 neutralising antibodies, but not by isotype controls. The neutralising antibodies, but not the isotype controls, were also able to significantly decrease the parasite load in macrophages cultured without the addition of KMP-11, demonstrating that KMP-11-induced exacerbation of the infection is not dependent on the addition of exogenous KMP-11 and that the protein naturally expressed by the parasite is able to promote it. In this study, the exacerbating effect of KMP-11 on macrophage infection with Leishmania is for the first time demonstrated, implicating it as a virulence factor in L. amazonensis. The stimulation of IL-10 production and arginase activity and the inhibition of NO synthesis are likely involved in this effect.
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Colbertinus
