Histoire et sagesse d'Ahikar l'assyrien (fils d'Anael, neveu de Tobie) / traduction des versions syriaques avec les principales différences des versions arabes, arménienne, grecque, néo-syriaque, slave et roumaine, par François Nau,...

[Sagesse d'Ahikar (français). 1909]

Extratos etanólicos da manga como antioxidantes para frangos de corte

O objetivo deste trabalho foi avaliar o efeito da inclusão de extratos etanólicos na ração, obtidos do caroço e da casca da manga, sobre o desempenho de frangos e a oxidação lipídica da carne. Foram utilizados 360 pintos machos da linhagem Ross 308, de um dia de idade, distribuídos em delineamento inteiramente casualizado, com seis tratamentos e seis repetições de dez aves. Os tratamentos consistiram de: ração sem adição de antioxidante (controle); ração com adição de 200 ppm do antioxidante butilato de hidroxitolueno (BHT); ração com 200 ou 400 ppm de extrato da casca da manga (ECAS); e ração com 200 ou 400 ppm de extrato do caroço da manga (ECAR). A adição de BHT ou dos extratos da manga não influenciou significativamente o consumo de ração, o ganho de peso e a conversão alimentar. A adição de BHT e a de 400 ppm de ECAR proporcionaram maior estabilidade lipídica da carne fresca, mensurada pelas substâncias reativas ao ácido tiobarbitúrico antes do armazenamento. O extrato etanólico do caroço da manga, na dosagem de 200 e 400 ppm, retarda a oxidação lipídica da carne de frangos armazenada por 15 dias.

[1 lettre d'Étienne Nétien à Halanzier, 18 mai 1876]

Lui fait part de l'incendie qui a ravagé le Théâtre des Arts de Rouen et la bibliothèque musicale de la ville. Sollicite l'expertise du bibliothécaire de l'Opéra pour évaluer le prix des œuvres perdues. - La lettre adressée au directeur de l'Opéra a été transmise à Charles Nuitter mais la liste des partitions jointe à la lettre est absente. - Armes de la ville et papier à en-tête: "Mairie de Rouen. Cabinet du Maire". - La lettre est accompagnée d'une note de Jules Delahaye, secrétaire général de l'Opéra, à l'attention de Nuitter

High-precision dating and origin of synsedimentary volcanism in the Late Carboniferous Salvan-Dorenaz basin (Aiguilles-Rouges Massif, Western Alps)

Late Variscan volcanic activity is documented in the Late Carboniferous Salvan-Dorenaz sedimentary basin and in the neighboring basement units of the Aiguilles-Rouges and Mont-Blanc crystalline massifs (Western Alps). Precise U/Pb isotopic dating, zircon morphology and geochemical analyses indicate that volcanism occurred during short-lived pulses and that coexisting crustal and mantle sources were involved in the production of melts. Volcanic and subvolcanic products were emplaced along major N-S to NNE-SSW transtensional fracture zones, similar to the ones that governed intense basement exhumation and that favored the formation and filling of the Late Carboniferous Salvan-Dorenaz continental basin. In the Aiguilles-Rouges massif, dacitic flows outcropping at the base of the Salvan-Dorenaz basin erupted at 308 +/- 3 Ma; they represent the surface equivalent of the nearby Vallorcine peraluminous granite and associated rhyolitic dykes (311 +/- 17 Ma). In the Mont Blanc massif, calc-alkaline rhyolitic dykes were emplaced simultaneously (307 +/- 2 Ma) at shallow crustal levels, but they derive from deeper magma sources denoting enhanced mantellic activity. Recently identified tuffs and volcaniclastic layers embedded at different levels of the Salvan-Dorenaz stratigraphic record testify a 295 +3/-4 Ma old episode of highly explosive volcanism from distant volcanic centers, possibly located in the Aar-Gotthard massifs (Central Alps). Their zircon typology is highly heterogeneous. documenting wall-rock contamination of the melts and/or admixture of crustal sediments, whereas consistent subpopulations point to high-temperature magmas of deep-seated origin and alkaline affinity. The dated volcanic layers from the Salvan-Dorenaz basin set the beginning of the detrital sedimentation at 308 +/- 3 Ma and constrain the deposition of 1.5-1.7 km thick of elastic sediments within a time span of 10-15 Ma. These results infer minimum, long-term subsidence rates during basin evolution in the order of >0.1 mm/a, while in the surrounding basement units estimated exhumation rates are in the range of 1 mm/a. All dated rocks contain inherited zircon populations about 350, 450 or 600 Ma old.

Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer

Background To determine the diagnostic and prognostic capability of urinary and tumoral syndecan-1 (SDC-1) levels in patients with cancer of the urinary bladder. Methods SDC-1 levels were quantitated by enzyme-linked immunosorbent assay (ELISA) in 308 subjects (102 cancer subjects and 206 non-cancer subjects) to assess its diagnostic capabilities in voided urine. The performance of SDC-1 was evaluated using the area under the curve of a receiver operating characteristic curve. In addition, immunohistochemical (IHC) staining assessed SDC-1 protein expression in 193 bladder specimens (185 cancer subjects and 8 non-cancer subjects). Outcomes were correlated to SDC-1 levels. Results Mean urinary levels of SDC-1 did not differ between the cancer subjects and the non-cancer subjects, however, the mean urinary levels of SDC-1 were reduced in high-grade compared to low-grade disease (p < 0.0001), and in muscle invasive bladder cancer (MIBC) compared to non-muscle invasive bladder cancer (NMIBC) (p = 0.005). Correspondingly, preliminary data note a shift from a membranous cellular localization of SDC-1 in normal tissue, low-grade tumors and NMIBC, to a distinctly cytoplasmic localization in high-grade tumors and MIBC was observed in tissue specimens. Conclusion Alone urinary SDC-1 may not be a diagnostic biomarker for bladder cancer, but its urinary levels and cellular localization were associated with the differentiation status of patients with bladder tumors. Further studies are warranted to define the potential role for SDC-1 in bladder cancer progression.

Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer

Background To determine the diagnostic and prognostic capability of urinary and tumoral syndecan-1 (SDC-1) levels in patients with cancer of the urinary bladder. Methods SDC-1 levels were quantitated by enzyme-linked immunosorbent assay (ELISA) in 308 subjects (102 cancer subjects and 206 non-cancer subjects) to assess its diagnostic capabilities in voided urine. The performance of SDC-1 was evaluated using the area under the curve of a receiver operating characteristic curve. In addition, immunohistochemical (IHC) staining assessed SDC-1 protein expression in 193 bladder specimens (185 cancer subjects and 8 non-cancer subjects). Outcomes were correlated to SDC-1 levels. Results Mean urinary levels of SDC-1 did not differ between the cancer subjects and the non-cancer subjects, however, the mean urinary levels of SDC-1 were reduced in high-grade compared to low-grade disease (p < 0.0001), and in muscle invasive bladder cancer (MIBC) compared to non-muscle invasive bladder cancer (NMIBC) (p = 0.005). Correspondingly, preliminary data note a shift from a membranous cellular localization of SDC-1 in normal tissue, low-grade tumors and NMIBC, to a distinctly cytoplasmic localization in high-grade tumors and MIBC was observed in tissue specimens. Conclusion Alone urinary SDC-1 may not be a diagnostic biomarker for bladder cancer, but its urinary levels and cellular localization were associated with the differentiation status of patients with bladder tumors. Further studies are warranted to define the potential role for SDC-1 in bladder cancer progression.

Origin and genome evolution of polyploid green toads in Central Asia: evidence from microsatellite markers.

Polyploidization, which is expected to trigger major genomic reorganizations, occurs much less commonly in animals than in plants, possibly because of constraints imposed by sex-determination systems. We investigated the origins and consequences of allopolyploidization in Palearctic green toads (Bufo viridis subgroup) from Central Asia, with three ploidy levels and different modes of genome transmission (sexual versus clonal), to (i) establish a topology for the reticulate phylogeny in a species-rich radiation involving several closely related lineages and (ii) explore processes of genomic reorganization that may follow polyploidization. Sibship analyses based on 30 cross-amplifying microsatellite markers substantiated the maternal origins and revealed the paternal origins and relationships of subgenomes in allopolyploids. Analyses of the synteny of linkage groups identified three markers affected by translocation events, which occurred only within the paternally inherited subgenomes of allopolyploid toads and exclusively affected the linkage group that determines sex in several diploid species of the green toad radiation. Recombination rates did not differ between diploid and polyploid toad species, and were overall much reduced in males, independent of linkage group and ploidy levels. Clonally transmitted subgenomes in allotriploid toads provided support for strong genetic drift, presumably resulting from recombination arrest. The Palearctic green toad radiation seems to offer unique opportunities to investigate the consequences of polyploidization and clonal transmission on the dynamics of genomes in vertebrates.

Le thresor des trois langues, espagnole, françoise, et italienne : auquel est contenuë l'explication de toutes les trois, respectivement l'une par l'autre... ([Reprod.]) / par Caesar Oudin, Nicot, La Crusca, et autres

Collection : Archives de la linguistique française ; 308

Nykyaikaisten ohjelmistotuotannon menetelmien hyödyntäminen pk-yritysten sovelluskehityksessä

Ketterillä menetelmillä tarkoitetaan erilaisista hyväksi havaituista ohjelmistotuotannon menetelmistä luotua sekä teoreettista että käytännöllistä viitekehystä. Nykyaikaiset ohjelmistotuotannon menetelmät, ketterät menetelmät ja käytettävyyssuunnittelu, vievät ohjelmistokehitystä kohtiasiakaslähtöisempää lähestymistapaa. Ohjelmien laadun takaamiseksi asiakas osallistuu tiiviisti jo ohjelmiston tuotantovaiheessa, jolloin turhilta ominaisuuksilta ja vääriltä ratkaisuilta vältytään paremmin. Tässä työssä käsitellään tapoja, joilla pk-yritys voisi parantaa toimintaansa ja saavuttaa siten kilpailuetua sovelluskehityksessä. Pk-yritys on suurempia yrityksiä paremmassa asemassa siinä, että se on luontaisesti ketterä ja nopea käännöksissään, mutta siltä puuttuu perinteet ohjelmistokehityksessä ja siksi käytössä voi olla kehittymättömiä ratkaisuja. Yrityksissä ohjelmistotuotannon muuttaminen kohti ketterämpiä menetelmiä ei ole mahdotonta, mutta se vaatii sekä työntekijöiltä että sidosryhmiltä halua ja sitoutumista kehitykseen. Jos edellä mainittuja asioita ei löydy, ei ketteriin menetelmiin siirtyminen ole järkevää, vaan yrityksen kannattaa pitäytyä nykyisissä menetelmissä ja kehittää niitä. Työssä käsitellään myös käytettävyyden suunnittelua ja sen toteutusta hyvin pienin muutoksin perinteisiin työtapoihin. Lähtökohtaisesti voidaan ajatella, etteivät pk-yrityksen voimavarat riitä täysimittaiseen käytettävyyssuunnitteluun, siksi työssä ehdotetaan keveitä ratkaisuja, joilla voidaan kuitenkin huomattavasti parantaa ohjelmiston käyttökokemusta.

La enseñanza de estrategias de resolución de problemas matemáticos en la ESO: un ejemplo concreto

Within this article is included a description and justification of a didactical sequence to improve the learning of problem solving strategies of Secondary Education students. The design of the didactical sequence is guided by four principles: a) to context the activities and problems to solve in students’ every day practices; b) to use teaching methods that show the problem solving processes; c) to design didactical materials in order to guide strategies such as selection, organisation and control; d) to facilitate the co-operative learning of problem solving strategies.

Short communication. Mutual pheromone antagonism in two sympatric corn borers, Sesamia nonagrioides and Ostrinia nubilalis, under field conditions

In previous studies, we demonstrated cross-antagonism in pheromone perception between pheromone componentsof the two corn (Zea mays L.) borers Sesamia nonagrioides Lefèbvre (Lepidoptera: Noctuidae) and Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae) in the laboratory and in the field. The two pheromone components identified as responsible for this cross-antagonism were Z 11-16:Ald, a minor component of S. nonagrioides pheromone, and Z 11-14:Ac, the main component of the pheromone of the Z-strain of O. nubilalis, which inhibited the response of O. nubilalis and S. nonagrioides, respectively. Here, we study this antagonism phenomenon in the field by air permeation of maize plots with each of the two components separately and measurement of mating in caged couples of the two corn borers on treated and untreated plots during three years. A significant reduction in mating rates was observed on the permeated plots: 7% for S. nonagrioides and 12% for O. nubilalis. When dispenser charges (200 ng) were increased by 50% and 75% in the third year, no decrease in mating rates was recorded at either of the increased concentrations. On the other hand, the use of large cages resulted in an increase of 8% to 12% in the percentage of unmated females in each of the two corn borers suggesting that at more realistic field corn borer densities, 0,1 couples/plant instead of the 2 couples/plant used in this experiment, cross-antagonism in the two corn borers could be higher than that recorded in small cages.