996 resultados para 205-1


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On verso of t.-p.: War Dept. Document no. 244. Office of the Chief of the Staff.

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Prepared by Sciences International, Inc. under subcontract to Research Triangle Institute under Contract No. 205-1999-00024 for the U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry."

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DEC-205 (CD205) belongs to the macrophage mannose receptor family of C-type lectin endocytic receptors and behaves as an antigen uptake/processing receptor for dendritic cells (DC). To investigate DEC-205 tissue distribution in human leukocytes, we generated a series of anti-human DEC-205 monoclonal antibodies (MMRI-5, 6 and 7), which recognized epitopes within the C-type lectin-like domains 1 and 2, and the MMRI-7 immunoprecipitated a single similar to 200 kDa band, identified as DEC-205 by mass spectrometry. MMRI-7 and another DEC-205 mAb (MG38), which recognized the epitope within the DEC-205 cysteine-rich and fibronectin type II domain, were used to examine DEC-205 expression by human leukocytes. Unlike mouse DEC-205, which is reported to have predominant expression on DC, human DEC-205 was detected by flow cytometry at relatively high levels on myeloid blood DC and monocytes, at moderate levels on B lymphocytes and at low levels on NK cells, plasmacytoid blood DC and T lymphocytes. MMRI-7 F(ab')(2) also labeled monocytes, B lymphocytes and NK cells similarly excluding reactivity due to non-specific binding of the mAb to Fc gamma R. Tonsil mononuclear cells showed a similar distribution of DEC-205 staining on the leukocytes. DEC-205-specific semiquantitative immunoprecipitation/western blot and quantitative reverse transcriptase-PCR analysis established that these leukocyte populations expressed DEC-205 protein and the cognate mRNA. Thus, human DEC-205 is expressed on more leukocyte populations than that were previously assumed based on mouse DEC-205 tissue localization studies. The broader DEC-205 tissue expression in man is relevant to clinical DC targeting strategies and DEC-205 functional studies.

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A Epístola aos Hebreus apresenta já em seus primeiros versos Jesus Cristo assentado à destra de Deus (Hebreus 1,1-4). Assim, desde o princípio a Carta aos Hebreus revela a estratégia de seu autor ao expressar Jesus Cristo em termos honrosos. Tais indícios sugerem o meio ambiente cultural típico do mundo mediterrâneo do século I E.C., em que honra e vergonha exerciam uma função pivô nessa sociedade. A estratégia de Hebreus apresenta a dignidade de Jesus Cristo e sustenta o controle social de seus leitores diante de uma eminente evasão do grupo religioso. Para isso, o autor de Hebreus lança mão de tradições angelológicas amplamente conhecidas do entorno religioso judaico do período do segundo templo. Caracterizam principalmente essas tradições elementos gloriosos desenvolvidos pela religião judaica (anjos, figuras hipostáticas, Melquisedec), que contribuíram para a confissão do Cristo exaltado de Hebreus. Fazemos um estudo da História das Religiões Comparadas das figuras mediadoras nos escritos do AT e da literatura pseudepígrafa, entendendo que essas figuras foram adquirindo cada vez mais características divinizadas possibilitando a elaboração da Cristologia angelomórfica de Hebreus 1.1-14; 2.5-18; 7.1-10. Além disso, uma aproximação sócio-retórica à Hebreus garante resultados mais claros no que diz respeito à estratégia pretendida por seu autor.

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A multinuclear Fe-Mn-Cr complex with 4-amino-1,2,4-triazole (NH2trz) and oxalate (ox) ligands has been synthesized successfully. The formula of the [Fe(NH2trz)3][ClO4][MnCr(ox)3].4H2O complex has been obtained based on the metal and C, H, N contents. The presence of water molecules, metal-ligand bonding and bridge ligand in the multinuclear complex has been confirmed by its infrared spectrum. The compound crystallizes in the hexagonal system with cell parameters of a = b = 18.695 Å and c = 57.351 Å. The compound shows a gradual spin crossover for iron(II) in the [Fe(NH2trz)3]2+ with transition temperature (T1/2) of 205 K. The antiferromagnetic interaction between Cr(III) and Mn(II) ions in the [MnCr(ox)3]n n- network is observed from the Weiss constant (θ) of –2.3 K.

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The role of the Sm3+ ions in the structure of vitreous Sm2O3•4P2O5 has been investigated using the neutron diffraction anomalous dispersion technique, which employs the wavelength dependence of the real and imaginary parts of the neutron scattering length close to an absorption resonance. The data described here represent the first successful complete neutron anomalous dispersion study on an amorphous material. This experimental methodology permits one to determine exclusively the closest Sm• •• Sm separation. Knowledge of the R•••R (R = rare-earth) pairwise correlation is key to understanding the optical and magnetic properties of rare-earth phosphate glasses. The anomalous difference correlation function, ΔT''(r), shows a dominant feature pertaining to a Sm•••Sm separation, centred at 4.8 Å. The substantial width and marked asymmetry of this peak indicates that the minimum approach of Sm3+ ions could be as close as 4 Å. Information on other pairwise correlations is also revealed via analysis of T (r) and ΔT (r) correlation functions: Sm3+ ions display an average co-ordination number, n Sm(O), of 7, with a mean Sm–O bond length of 2.375(5) Å whilst the PO4 tetrahedra have a mean P–O bond length of 1.538(2) Å. Second- and third-neighbour correlations are also identified. These results corroborate previous findings. Such consistency lends support to the application of the anomalous dispersion technique to determine separations.

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Planktic foraminifers Neogloboquadrina pachyderma (sin.) from 87 eastern and central Arctic Ocean surface sediment samples were analyzed for stable oxygen and carbon isotope composition. Additional results from 52 stations were taken from the literature. The lateral distribution of delta18O (18O/16O) values in the Arctic Ocean reveals a pattern of roughly parallel, W-E stretching zones in the Eurasian Basin, each ~0.5 per mil wide on the delta18O scale. The low horizontal and vertical temperature variability in the Arctic halocline waters (0-100 m) suggests only little influence of temperature on the oxygen isotope distribution of N. pachyderma (sin.). The zone of maximum delta18O values of up to 3.8 per mil is situated in the southern Nansen Basin and relates to the tongue of saline (> 33%.) Atlantic waters entering the Arctic Ocean through the Fram Strait. delta18O values decrease both to the Barents Shelf and to the North Pole, in accordance with the decreasing salinities of the halocline waters. In the Nansen Basin, a strong N-S delta18O gradient is in contrast with a relatively low salinity change and suggests contributions from different freshwater sources, i.e. salinity reduction from sea ice meltwater in the south and from light isotope waters (meteoric precipitation and river-runoff) in the northern part of the basin. North of the Gakkel Ridge, delta18O and salinity gradients are in good accordance and suggest less influence of sea ice melting processes. The delta13C (13C/12C) values of N. pachyderma (sin.) from Arctic Ocean surface sediment samples are generally high (0.75-0.95 per mil). Lower values in the southern Eurasian Basin appear to be related to the intrusion of Atlantic waters. The high delta13C values are evidence for well ventilated surface waters. Because the perennial Arctic sea ice cover largely prevents atmosphere-ocean gas exchange, ventilation on the seasonally open shelves must be of major importance. Lack of delta13C gradients along the main routes of the ice drift from the Siberian shelves to the Fram Strait suggests that primary production (i.e. CO2 consumption) does probably not change the CO2 budget of the Arctic Ocean significantly.

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We investigate whether the oxygen isotope ratio in the test of Globorotalia truncatulinoides can serve as a proxy for intermediate depth (200-500 m) density. Since intermediate depth horizontal density gradients are associated with the vertical shear of upper ocean flows, this proxy could provide a tool for reconstructing past ocean circulation. The spatial pattern of core top Gr. truncatulinoides d18O in the Atlantic Ocean mimics the upper ocean density gradients associated with the major ocean currents. To better constrain the controls on the calcification depth(s) of Gr. truncatulinoides, we attempt to simulate the surface sediment data set using water column temperature and salinity conditions above the core sites. We predicted foraminiferal d18O for each core site assuming (1) the calcification occurs at a single depth and (2) the initial calcification is at the surface and the subsequent calcification is at 800 m water depth. The predicted d18O best resembles measured d18O of Gr. truncatulinoides when using (1) a single depth calcification at 350 m or (2) a two-depth approximation with 30% surface and 70% 800-m calcification. This result gives us confidence in the ability of d18O in Gr. truncatulinoides to proxy lateral density gradients at the intermediate depths associated with upper ocean flow.

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he separate roles of oceanic heat advection and orbital forcing on influencing early Holocene temperature variability in the eastern Nordic Seas is investigated. The effect of changing orbital forcing on the ocean temperatures is tested using the 1DICE model, and the 1DICE results are compared with new and previously published temperature reconstructions from a transect of five cores located underneath the pathway of Atlantic water, from the Faroe-Shetland Channel in the south to the Barents Sea in the north. The stronger early Holocene summer insolation at high northern latitudes increased the summer mixed layer temperatures, however, ocean temperatures underneath the summer mixed layer did not increase significantly. The absolute maximum in summer mixed layer temperatures occurred between 9 and 6 ka BP, representing the Holocene Thermal Maximum in the eastern Nordic Seas. In contrast, maximum in northward oceanic heat transport through the Norwegian Atlantic Current occurred approximately 10 ka BP. The maximum in oceanic heat transport at 10 ka BP occurred due to a major reorganization of the Atlantic Ocean circulation, entailing strong and deep rejuvenation of the Atlantic Meridional Overturning Circulation, combined with changes in the North Atlantic gyre dynamic causing enhanced transport of heat and salt into the Nordic Seas.

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In the GH77-1 cruise, manganese nodules were obtained from 31 stations among 37 total ones. Here are reported the preliminary results of the observation mainly done on-board. Special attention was paid to confirming the applicability of the nodule type classification tentatively established in the previous GH76-1 cruise and to delineating the pattern of the nodule distribution and clarifying its relation to the geological factors, such as topography, surface sediment types, and substrate stratigraphy. In addition, a short description of the obtained rock samples from a few stations is included in this chapter.

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The thermal structure of the Pacific Ocean between water depths of about 1 and 4.5 kilometers is estimated from the oxygen isotopic ratio of benthonic foraminifera from deep-drilled and piston cores of early Pliocene age (about 3 to 5 million years ago). The ratio of oxygen-18 to oxygen-16 in the early Pliocene at each site varies by an average of only ± 0.12 per mil (1 standard deviation). A plot of the oxygen isotopic ratio against modern bottom-water temperature is adequately fit by a line having a slope of - 0.26 per mil per degree Celsius (the equilibrium temperature dependence of calcite-water fractionation), suggesting that the temperature gradient of the Pacific Ocean during the early Pliocene was similar to that of today.