504 resultados para 1541
Resumo:
Mode of access: Internet.
Resumo:
Includes bibliographical references.
Resumo:
Plates printed on both sides.
Resumo:
Trägerband: '1541'; Vorbesitzer: Stadtarchiv Frankfurt am Main (?)
Resumo:
Despite improvements in interventional and pharmacological therapy of atherosclerotic disease, it is still the leading cause of death in the developed world. Hence, there is a need for further development of effective therapeutic approaches. This requires better understanding of the molecular mechanisms and pathophysiology of the disease. Atherosclerosis has long been identified as having an inflammatory component contributing to its pathogenesis, whereas the available therapy primarily targets hyperlipidemia and prevention of thrombosis. Notwithstanding a pleotropic anti-inflammatory effect to some therapies, such as acetyl salicylic acid and the statins, none of the currently approved medicines for management of either stable or complicated atherosclerosis has inflammation as a primary target. Monocytes, as representatives of the innate immune system, play a major role in the initiation, propagation, and progression of atherosclerosis from a stable to an unstable state. Experimental data support a role of monocytes in acute coronary syndromes and in outcome post-infarction; however, limited research has been done in humans. Analysis of expression of various cell surface receptors allows characterization of the different monocyte subsets phenotypically, whereas downstream assessment of inflammatory pathways provides an insight into their activity. In this review we discuss the functional role of monocytes and their different subpopulations in atherosclerosis, acute coronary syndromes, cardiac healing, and recovery with an aim of critical evaluation of potential future therapeutic targets in atherosclerosis and its complications. We will also discuss technical difficulties of delineating different monocyte subpopulations, understanding their differentiation potential and function.
Resumo:
Data fluctuation in multiple measurements of Laser Induced Breakdown Spectroscopy (LIBS) greatly affects the accuracy of quantitative analysis. A new LIBS quantitative analysis method based on the Robust Least Squares Support Vector Machine (RLS-SVM) regression model is proposed. The usual way to enhance the analysis accuracy is to improve the quality and consistency of the emission signal, such as by averaging the spectral signals or spectrum standardization over a number of laser shots. The proposed method focuses more on how to enhance the robustness of the quantitative analysis regression model. The proposed RLS-SVM regression model originates from the Weighted Least Squares Support Vector Machine (WLS-SVM) but has an improved segmented weighting function and residual error calculation according to the statistical distribution of measured spectral data. Through the improved segmented weighting function, the information on the spectral data in the normal distribution will be retained in the regression model while the information on the outliers will be restrained or removed. Copper elemental concentration analysis experiments of 16 certified standard brass samples were carried out. The average value of relative standard deviation obtained from the RLS-SVM model was 3.06% and the root mean square error was 1.537%. The experimental results showed that the proposed method achieved better prediction accuracy and better modeling robustness compared with the quantitative analysis methods based on Partial Least Squares (PLS) regression, standard Support Vector Machine (SVM) and WLS-SVM. It was also demonstrated that the improved weighting function had better comprehensive performance in model robustness and convergence speed, compared with the four known weighting functions.
Resumo:
Electric vehicles (EVs) and hybrid electric vehicles (HEVs) can reduce greenhouse gas emissions while switched reluctance motor (SRM) is one of the promising motor for such applications. This paper presents a novel SRM fault-diagnosis and fault-tolerance operation solution. Based on the traditional asymmetric half-bridge topology for the SRM driving, the central tapped winding of the SRM in modular half-bridge configuration are introduced to provide fault-diagnosis and fault-tolerance functions, which are set idle in normal conditions. The fault diagnosis can be achieved by detecting the characteristic of the excitation and demagnetization currents. An SRM fault-tolerance operation strategy is also realized by the proposed topology, which compensates for the missing phase torque under the open-circuit fault, and reduces the unbalanced phase current under the short-circuit fault due to the uncontrolled faulty phase. Furthermore, the current sensor placement strategy is also discussed to give two placement methods for low cost or modular structure. Simulation results in MATLAB/Simulink and experiments on a 750-W SRM validate the effectiveness of the proposed strategy, which may have significant implications and improve the reliability of EVs/HEVs.
Resumo:
Projects of Energy Community Interest” (PECIs) is a label attached to those projects which have the highest positive impact in the largest possible number of Contracting Parties. The assessment of one hundred projects submitted as candidates, and final selection of 35 PECIs was achieved in a collaborative process undertaken by the same Task Force that contributed to the preparation of the Energy Strategy. Chaired by the European Commission, the Task Force was facilitated by the Energy Community Secretariat and benefited from technical assistance of a Consultant sponsored from the Energy Community budget.
Resumo:
Vol. 23, Issue 5, 8 pages
Resumo:
Relatório de estágio para a obtenção do grau de mestre na especialidade profissional de Educação pré-escolar
Resumo:
A partir do governo do Presidente Fernando Henrique Cardoso (1995-2003), houve incentivo para abertura de novas Instituições privadas de ensino superior no Brasil. Os alunos tornam-se clientes e começam a escolher a melhor opção de instituição de ensino superior (IES) que atenda às suas necessidades. O objetivo desta dissertação é compreender limites e policiamentos no desenvolvimento da comunicação mercadológica de IES confessionais na captação de novos alunos. A pesquisa desenvolvida foi a partir de um estudo exploratório descritivo, por meio de revisão bibliográfica e pesquisa qualitativa com entrevistas com executivos de comunicação da UMESP. Os principais resultados apontam para uma maior restrição no desenvolvimento da comunicação mercadológica da IES em estudo (UMESP), notadamente na vigilância sobre a veracidade e alcance do texto publicitário
Resumo:
This article is protected by copyright. All rights reserved. Acknowledgements We thank Tamara Ben-Ari and Jean-Francois Soussana, from INRA in France, for their valuable contributions to the early development stage of this project. We also owe great acknowledge to Prof. Ib Skovgaard, University of Copenhagen, for giving essential assistance in developing the methods for decomposing emission changes. We also thank the Centre for Regional Change in the Earth System (CRES, www.cres-centre.dk) and the Department of Plant- and Environmental Sciences, University of Copenhagen, for funding the work.