Valtiosihteeri Jorma Vanamo 13/6 1969

Kirje 13.6.1969

Vastaus (puolueiden delegaatiolle 13.4.1967)

Puhe

Budapestissa 13/6 -28

Kirje 13.6.1928

Maintenance Service Level Map, October 13, 2006

Maintenance Service Level Map

Vuorineuvos Ilmo O. Nurmela 13/9 1968

Kirje 13.9.1968

QUALIDADE DO SONO, HIGIENE DO SONO, CRENÇAS DISFUNCIONAIS SOBRE O SONO, E TEMPERAMENTO EM ADOLESCENTES Estudo exploratório com adolescentes entre os 13 e os 19 anos

O sono desempenha um papel importante no desenvolvimento físico e emocional dos adolescentes (Del Ciampo, 2012). As perturbações de sono na adolescência são um problema com uma prevalência significativa (Mindell & Owens, 2010). As suas consequências interferem no bem-estar e no desenvolvimento saudável desta população (Hamilton, 2009). É atualmente reconhecida a pertinência do estudo dos determinantes do sono na adolescência. Esta investigação teve como primeiro objetivo descrever o padrão de sono, avaliar a perceção de qualidade do sono, a higiene do sono, as crenças disfuncionais em relação ao sono, e a relação entre o temperamento e o sono, numa amostra comunitária de adolescentes portugueses. Foram ainda consideradas como variáveis independentes o controlo parental da hora de deitar e a perceção de problemas de sono. Num segundo objetivo foi considerado o estudo das associações entre as variáveis. Como terceiro objetivo pretendeu-se avaliar a contribuição das variáveis para a qualidade do sono. Foram utilizadas as versões portuguesas de 4 questionários: a escala de Autoavaliação da Qualidade do Sono na Adolescência - AQSA, a Escala de Higiene do Sono para Adolescentes - EHSA, a Escala de Crenças Disfuncionais sobre o Sono – ECDS e o Questionário sobre o Temperamento no Início da Adolescência-Revisto – EATQ-R. Integraram a amostra 164 participantes, com idades entre os 13 e os 19 anos (M=15,37; DP=1,16). A recolha de dados teve lugar num Estabelecimento Público de Ensino Básico e Secundário, em Lisboa. Os resultados mostraram que os adolescentes dormem menos uma hora do que o recomendado durante a semana. A discrepância de horas dormidas durante a semana e o fim-de-semana é significativa (2h04). Apenas 27% dos pais participam no estabelecimento de horas para dormir. Os adolescentes da amostra apresentam valores médios de qualidade do sono, com piores resultados no domínio “acordar”; valores médios de higiene do sono com piores valores no domínio “estabilidade do sono”; e crenças pouco disfuncionais sobre o sono. 35% da amostra considera ter problemas de sono. As raparigas apresentam piores resultados na qualidade e higiene do sono, crenças mais disfuncionais sobre o sono. Os iv 4 constructos apresentam correlações significativas entre si. A higiene do sono, e os fatores do temperamento, “afetividade negativa”, “extroversão” e “controlo com esforço” mostraram ser preditores da qualidade do sono. No modelo final a idade, o género, o controlo parental e as crenças em relação ao sono mostraram não ter efeito em relação à qualidade do sono. O modelo preditivo explicou 33,5% da variabilidade da qualidade do sono.

Influenza and Other Respiratory Virus Weekly Activity Report, April 4, 2009, Week 13

Weekly report of the Iowa Influenza Surveillance Network produced by the Iowa Department of Public Health.

Influenza and Other Respiratory Virus Weekly Activity Report, June 13, 2009, revised Week 23

Weekly report of the Iowa Influenza Surveillance Network produced by the Iowa Department of Public Health.

Iowa Growers' News, November 13, 2007, Issue 2

Newsletter produced by Iowa Department of Agriculture and Land Stewardship for Iowa Growers.

El calamar gigante Dosidicus gigas, primavera 2001. Crucero BIC Shinko Maru Nº 3

El crucero se desarrolló en dos etapas del 17 de octubre al 12 de diciembre 2001, desde 3°30› a 16°S, de 37 a 208 mn de la costa. La captura total fue 281.123 kg. La captura por unidad de esfuerzo (CPUE) fue 58,5 a 1.037,3 kg/hora; 13,6 a 780,35 kg/línea y 1,36 a 78,03 kg/línea*hora. La longitud del manto varió de 18 a 115 cm, media 58,37 cm. Se registró hembras inmaduras (57,1%) y desovantes III (28,5%) y machos desovantes (59,7%) e inmaduros (35,9%). Se experimentó la fertilización artificial alcanzando hasta el estadio 12 de desarrollo embrionario.

Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial.

BACKGROUND: Concomitant chemoradiotherapy and accelerated radiotherapy independently improve outcomes for patients with locally advanced head and neck squamous-cell carcinoma (HNSCC). We aimed to assess the efficacy and safety of a combination of these approaches. METHODS: In our open-label phase 3 randomised trial, we enrolled patients with locally advanced, stage III and IV (non-metastatic) HNSCC and an Eastern Cooperative Oncology Group performance status of 0-2. We randomly allocated patients centrally with a computer program (with centre, T stage, N stage, and localisation as minimisation factors) in a 1:1:1 ratio to receive conventional chemoradiotherapy (70 Gy in 7 weeks plus three cycles of 4 days' concomitant carboplatin-fluorouracil), accelerated radiotherapy-chemotherapy (70 Gy in 6 weeks plus two cycles of 5 days' concomitant carboplatin-fluorouracil), or very accelerated radiotherapy alone (64·8 Gy [1·8 Gy twice daily] in 3·5 weeks). The primary endpoint, progression-free survival (PFS), was assessed in all enrolled patients. This trial is completed. The trial is registered with ClinicalTrials.gov, number NCT00828386. FINDINGS: Between Feb 29, 2000, and May 9, 2007, we randomly allocated 279 patients to receive conventional chemoradiotherapy, 280 to accelerated radiotherapy-chemotherapy, and 281 to very accelerated radiotherapy. Median follow-up was 5·2 years (IQR 4·9-6·2); rates of chemotherapy and radiotherapy compliance were good in all groups. Accelerated radiotherapy-chemotherapy offered no PFS benefit compared with conventional chemoradiotherapy (HR 1·02, 95% CI 0·84-1·23; p=0·88) or very accelerated radiotherapy (0·83, 0·69-1·01; p=0·060); conventional chemoradiotherapy improved PFS compared with very accelerated radiotherapy (0·82, 0·67-0·99; p=0·041). 3-year PFS was 37·6% (95% CI 32·1-43·4) after conventional chemoradiotherapy, 34·1% (28·7-39·8) after accelerated radiotherapy-chemotherapy, and 32·2% (27·0-37·9) after very accelerated radiotherapy. More patients in the very accelerated radiotherapy group had RTOG grade 3-4 acute mucosal toxicity (226 [84%] of 268 patients) compared with accelerated radiotherapy-chemotherapy (205 [76%] of 271 patients) or conventional chemoradiotherapy (180 [69%] of 262; p=0·0001). 158 (60%) of 265 patients in the conventional chemoradiotherapy group, 176 (64%) of 276 patients in the accelerated radiotherapy-chemotherapy group, and 190 (70%) of 272 patients in the very accelerated radiotherapy group were intubated with feeding tubes during treatment (p=0·045). INTERPRETATION: Chemotherapy has a substantial treatment effect given concomitantly with radiotherapy and acceleration of radiotherapy cannot compensate for the absence of chemotherapy. We noted the most favourable outcomes for conventional chemoradiotherapy, suggesting that acceleration of radiotherapy is probably not beneficial in concomitant chemoradiotherapy schedules. FUNDING: French Ministry of Health.

Four 13-lipoxygenases contribute to rapid jasmonate synthesis in wounded Arabidopsis thaliana leaves: a role for lipoxygenase 6 in responses to long-distance wound signals.

Damage-inducible defenses in plants are controlled in part by jasmonates, fatty acid-derived regulators that start to accumulate within 30 s of wounding a leaf. Using liquid chromatography-tandem mass spectrometry, we sought to identify the 13-lipoxygenases (13-LOXs) that initiate wound-induced jasmonate synthesis within a 190-s timeframe in Arabidopsis thaliana in 19 single, double, triple and quadruple mutant combinations derived from the four 13-LOX genes in this plant. All four 13-LOXs were found to contribute to jasmonate synthesis in wounded leaves: among them LOX6 showed a unique behavior. The relative contribution of LOX6 to jasmonate synthesis increased with distance from a leaf tip wound, and LOX6 was the only 13-LOX necessary for the initiation of early jasmonate synthesis in leaves distal to the wounded leaf. Herbivory assays that compared Spodoptera littoralis feeding on the lox2-1 lox3B lox4A lox6A quadruple mutant and the lox2-1 lox3B lox4A triple mutant revealed a role for LOX6 in defense of the shoot apical meristem. Consistent with this, we found that LOX6 promoter activity was strong in the apical region of rosettes. The LOX6 promoter was active in and near developing xylem cells and in expression domains we term subtrichomal mounds.

Estimation of percentage body fat in 6- to 13-year-old children by skinfold thickness, body mass index and waist circumference.

We evaluated the accuracy of skinfold thicknesses, BMI and waist circumference for the prediction of percentage body fat (PBF) in a representative sample of 372 Swiss children aged 6-13 years. PBF was measured using dual-energy X-ray absorptiometry. On the basis of a preliminary bootstrap selection of predictors, seven regression models were evaluated. All models included sex, age and pubertal stage plus one of the following predictors: (1) log-transformed triceps skinfold (logTSF); (2) logTSF and waist circumference; (3) log-transformed sum of triceps and subscapular skinfolds (logSF2); (4) log-transformed sum of triceps, biceps, subscapular and supra-iliac skinfolds (logSF4); (5) BMI; (6) waist circumference; (7) BMI and waist circumference. The adjusted determination coefficient (R² adj) and the root mean squared error (RMSE; kg) were calculated for each model. LogSF4 (R² adj 0.85; RMSE 2.35) and logSF2 (R² adj 0.82; RMSE 2.54) were similarly accurate at predicting PBF and superior to logTSF (R² adj 0.75; RMSE 3.02), logTSF combined with waist circumference (R² adj 0.78; RMSE 2.85), BMI (R² adj 0.62; RMSE 3.73), waist circumference (R² adj 0.58; RMSE 3.89), and BMI combined with waist circumference (R² adj 0.63; RMSE 3.66) (P < 0.001 for all values of R² adj). The finding that logSF4 was only modestly superior to logSF2 and that logTSF was better than BMI and waist circumference at predicting PBF has important implications for paediatric epidemiological studies aimed at disentangling the effect of body fat on health outcomes.