Vastaus (puolueiden delegaatiolle 13.4.1967)

Puhe

Budapestissa 13/6 -28

Kirje 13.6.1928

Maintenance Service Level Map, October 13, 2006

Maintenance Service Level Map

Vuorineuvos Ilmo O. Nurmela 13/9 1968

Kirje 13.9.1968

QUALIDADE DO SONO, HIGIENE DO SONO, CRENÇAS DISFUNCIONAIS SOBRE O SONO, E TEMPERAMENTO EM ADOLESCENTES Estudo exploratório com adolescentes entre os 13 e os 19 anos

O sono desempenha um papel importante no desenvolvimento físico e emocional dos adolescentes (Del Ciampo, 2012). As perturbações de sono na adolescência são um problema com uma prevalência significativa (Mindell & Owens, 2010). As suas consequências interferem no bem-estar e no desenvolvimento saudável desta população (Hamilton, 2009). É atualmente reconhecida a pertinência do estudo dos determinantes do sono na adolescência. Esta investigação teve como primeiro objetivo descrever o padrão de sono, avaliar a perceção de qualidade do sono, a higiene do sono, as crenças disfuncionais em relação ao sono, e a relação entre o temperamento e o sono, numa amostra comunitária de adolescentes portugueses. Foram ainda consideradas como variáveis independentes o controlo parental da hora de deitar e a perceção de problemas de sono. Num segundo objetivo foi considerado o estudo das associações entre as variáveis. Como terceiro objetivo pretendeu-se avaliar a contribuição das variáveis para a qualidade do sono. Foram utilizadas as versões portuguesas de 4 questionários: a escala de Autoavaliação da Qualidade do Sono na Adolescência - AQSA, a Escala de Higiene do Sono para Adolescentes - EHSA, a Escala de Crenças Disfuncionais sobre o Sono – ECDS e o Questionário sobre o Temperamento no Início da Adolescência-Revisto – EATQ-R. Integraram a amostra 164 participantes, com idades entre os 13 e os 19 anos (M=15,37; DP=1,16). A recolha de dados teve lugar num Estabelecimento Público de Ensino Básico e Secundário, em Lisboa. Os resultados mostraram que os adolescentes dormem menos uma hora do que o recomendado durante a semana. A discrepância de horas dormidas durante a semana e o fim-de-semana é significativa (2h04). Apenas 27% dos pais participam no estabelecimento de horas para dormir. Os adolescentes da amostra apresentam valores médios de qualidade do sono, com piores resultados no domínio “acordar”; valores médios de higiene do sono com piores valores no domínio “estabilidade do sono”; e crenças pouco disfuncionais sobre o sono. 35% da amostra considera ter problemas de sono. As raparigas apresentam piores resultados na qualidade e higiene do sono, crenças mais disfuncionais sobre o sono. Os iv 4 constructos apresentam correlações significativas entre si. A higiene do sono, e os fatores do temperamento, “afetividade negativa”, “extroversão” e “controlo com esforço” mostraram ser preditores da qualidade do sono. No modelo final a idade, o género, o controlo parental e as crenças em relação ao sono mostraram não ter efeito em relação à qualidade do sono. O modelo preditivo explicou 33,5% da variabilidade da qualidade do sono.

Influenza and Other Respiratory Virus Weekly Activity Report, April 4, 2009, Week 13

Weekly report of the Iowa Influenza Surveillance Network produced by the Iowa Department of Public Health.

Influenza and Other Respiratory Virus Weekly Activity Report, June 13, 2009, revised Week 23

Weekly report of the Iowa Influenza Surveillance Network produced by the Iowa Department of Public Health.

Iowa Growers' News, November 13, 2007, Issue 2

Newsletter produced by Iowa Department of Agriculture and Land Stewardship for Iowa Growers.

Monitoreo bio-oceanográfico pesquero en el litoral sur del Perú. MOBOP 0708.

El monitoreo se realizó en agosto 2007, a bordo de la L/P IMARPE IV, desde La Yarada hasta 40 mn frente a Quilca. La temperatura superficial varió de 13,7 a 16,4 °C, menores valores (<14,5 °C) se registraron entre Tancona y Quilca dentro de las 15 mn y mayores (>16 °C) entre Punta Coles y el Dominio Marítimo Sur por fuera de 20 mn. Las anomalías térmicas variaron de -1,4 a -0,8 °C. La gradiente térmica vertical estuvo conformada por 3 isotermas (14 a 16 °C), la isolínea de 15 °C se presentó entre la superficie (zonas costeras) y 35 m. La anchoveta tuvo mayor distribución hasta 40 mn frente a Mollendo, dentro de las 5 mn se ubicó mezclada con múnida, principalmente frente a Playa Tacna y Mollendo.

Reshaping the remodelled left ventricle: a new concept.

OBJECTIVE: Based on the law of Laplace, transventricular tension members were designed to diminish wall stress by changing the left ventricle (LV) globular shape to a bilobular one, thus reducing the ventricular wall radius of curvature. This concept was tested in a model of congestive heart failure. METHODS: Seven calves were used for the study (74.3+/-4.2 kg). Treatment efficacy was assessed with sonomicrometric wall motion analysis coupled with intraventricular pressure measurement. Preload increase was applied stepwise with tension members in released and tightened position. RESULTS: Tightening of the tension members improved systolic function for CVP>10 mmHg (dP/dt: 828+/-122 vs. 895+/-112 mmHg/s, P=0.019, for baseline and 20% stress level reduction respectively; wall thickening: 11.6+/-1.5 vs. 13.3+/-1.7%, P<0.001) and diastolic function (LV end-diastolic pressure: 15.9+/-4.8 vs. 13.6+/-2.7 mmHg, P<0.001, for CVP>10 mmHg; peak rate of wall thinning: -12.2+/-2.2 vs. -14+/-2.3 cm(2)/s, P<0.001 and logistic time constant of isovolumic relaxation: 48.4 +/-10.9 vs. 39.8+/-9.6ms, P<0.001, for CVP>5 mmHg). CONCLUSIONS: This less aggressive LV reduction method significantly improves contractility and relaxation parameters in this model of congestive heart failure.

Four 13-lipoxygenases contribute to rapid jasmonate synthesis in wounded Arabidopsis thaliana leaves: a role for lipoxygenase 6 in responses to long-distance wound signals.

Damage-inducible defenses in plants are controlled in part by jasmonates, fatty acid-derived regulators that start to accumulate within 30 s of wounding a leaf. Using liquid chromatography-tandem mass spectrometry, we sought to identify the 13-lipoxygenases (13-LOXs) that initiate wound-induced jasmonate synthesis within a 190-s timeframe in Arabidopsis thaliana in 19 single, double, triple and quadruple mutant combinations derived from the four 13-LOX genes in this plant. All four 13-LOXs were found to contribute to jasmonate synthesis in wounded leaves: among them LOX6 showed a unique behavior. The relative contribution of LOX6 to jasmonate synthesis increased with distance from a leaf tip wound, and LOX6 was the only 13-LOX necessary for the initiation of early jasmonate synthesis in leaves distal to the wounded leaf. Herbivory assays that compared Spodoptera littoralis feeding on the lox2-1 lox3B lox4A lox6A quadruple mutant and the lox2-1 lox3B lox4A triple mutant revealed a role for LOX6 in defense of the shoot apical meristem. Consistent with this, we found that LOX6 promoter activity was strong in the apical region of rosettes. The LOX6 promoter was active in and near developing xylem cells and in expression domains we term subtrichomal mounds.

Estimation of percentage body fat in 6- to 13-year-old children by skinfold thickness, body mass index and waist circumference.

We evaluated the accuracy of skinfold thicknesses, BMI and waist circumference for the prediction of percentage body fat (PBF) in a representative sample of 372 Swiss children aged 6-13 years. PBF was measured using dual-energy X-ray absorptiometry. On the basis of a preliminary bootstrap selection of predictors, seven regression models were evaluated. All models included sex, age and pubertal stage plus one of the following predictors: (1) log-transformed triceps skinfold (logTSF); (2) logTSF and waist circumference; (3) log-transformed sum of triceps and subscapular skinfolds (logSF2); (4) log-transformed sum of triceps, biceps, subscapular and supra-iliac skinfolds (logSF4); (5) BMI; (6) waist circumference; (7) BMI and waist circumference. The adjusted determination coefficient (R² adj) and the root mean squared error (RMSE; kg) were calculated for each model. LogSF4 (R² adj 0.85; RMSE 2.35) and logSF2 (R² adj 0.82; RMSE 2.54) were similarly accurate at predicting PBF and superior to logTSF (R² adj 0.75; RMSE 3.02), logTSF combined with waist circumference (R² adj 0.78; RMSE 2.85), BMI (R² adj 0.62; RMSE 3.73), waist circumference (R² adj 0.58; RMSE 3.89), and BMI combined with waist circumference (R² adj 0.63; RMSE 3.66) (P < 0.001 for all values of R² adj). The finding that logSF4 was only modestly superior to logSF2 and that logTSF was better than BMI and waist circumference at predicting PBF has important implications for paediatric epidemiological studies aimed at disentangling the effect of body fat on health outcomes.

Predicting Adverse Events in Children with Fever and Chemotherapy-Induced Neutropenia. Results of the Prospective Multicenter SPOG 2003 FN Study

PURPOSE To develop a score predicting the risk of adverse events (AEs) in pediatric patients with cancer who experience fever and neutropenia (FN) and to evaluate its performance. PATIENTS AND METHODS Pediatric patients with cancer presenting with FN induced by nonmyeloablative chemotherapy were observed in a prospective multicenter study. A score predicting the risk of future AEs (ie, serious medical complication, microbiologically defined infection, radiologically confirmed pneumonia) was developed from a multivariate mixed logistic regression model. Its cross-validated predictive performance was compared with that of published risk prediction rules. Results An AE was reported in 122 (29%) of 423 FN episodes. In 57 episodes (13%), the first AE was known only after reassessment after 8 to 24 hours of inpatient management. Predicting AE at reassessment was better than prediction at presentation with FN. A differential leukocyte count did not increase the predictive performance. The score predicting future AE in 358 episodes without known AE at reassessment used the following four variables: preceding chemotherapy more intensive than acute lymphoblastic leukemia maintenance (weight = 4), hemoglobin > or = 90 g/L (weight = 5), leukocyte count less than 0.3 G/L (weight = 3), and platelet count less than 50 G/L (weight = 3). A score (sum of weights) > or = 9 predicted future AEs. The cross-validated performance of this score exceeded the performance of published risk prediction rules. At an overall sensitivity of 92%, 35% of the episodes were classified as low risk, with a specificity of 45% and a negative predictive value of 93%. CONCLUSION This score, based on four routinely accessible characteristics, accurately identifies pediatric patients with cancer with FN at risk for AEs after reassessment.