730 resultados para novelty inventive


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The aim of this study is to analyze the impact of food shortage on growth performance, by means of energetic reserves (proteins, glycogen and lipids) mobilization and hepatopancreas cells analysis in C. quadricarinatus juveniles maintained in groups, as well as the effect on culture water quality. Two experiments were performed, each of them with two feeding regimes during 45 days. The Control feeding regime, in which crayfish were fed daily (once a day) throughout the experimental period (DF), and the Cyclic feeding regime, in which juveniles were fed for 2 or 4 days (once a day) followed by 2 or 4 days of food deprivation (2F/2D and 4F/4D, respectively) in repeated cycles. Cyclic feeding influenced growth, biochemical composition from hepatopancreas and muscle, and water quality. Juveniles cyclically fed were unable to maintain a normal growth trajectory during 45 days. Apparent feed conversion ratio, apparent protein efficiency ratio, hepatosomatic index and relative pleon mass were similar in cyclic and daily fed animals and no structural damage was found in the hepatopancreas of juveniles subjected to cyclic feeding. The novelty of this study was the significant accumulation of proteins in pleonal muscle in both cyclic feeding regimes (approx. 18%) suggesting that the storage of this constitutive material during food shortage may be an adaptation for a compensatory growth when food becomes abundant again. The cyclic feeding regimes had a positive effect on water quality decreasing inorganic nitrogen concentration. This was due to the reduction in the amount of animal excretes and feces in the group that received approx. 50% less feed. Additionally, water pH was higher in cyclic feeding tanks, as a result of lower organic matter decomposition and consequent release of CO2. Accordingly, total ammonia in the water was significantly lower for the cyclic feeding regimes compared to their respective controls. This study suggests that the protocol of cyclic feeding could be applied at least 45 days in 1 g juveniles maintained in group conditions, without affecting the energetic reserves and hepatopancreas structure, emphasizing the high tolerance of this species to food restriction.

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The jambu belongs to the family Asteraceae, tropical crop, nowadays, this plant has been considered as a promising vegetable crop, because to its pharmacological properties. Despite this novelty, the vegetable remains invisible in the statistics of production and market in the state of Para, Brazil. This research was carried out with the aim of comparing the economic productivity and phenological development by the morpho-physiological growth indexes of two cultivars of jambu organic manure and mineral fertilizers. The experiment was carried out at the Sao Manuel Experimental Farm (Sao Manuel-SP), which belongs to the Faculdade de Ciencias Agronomicas - UNESP, campus Botucatu. The experimental design was a factorial randomized blocks (2 x 2) with two fertilization (organic and mineral) and two cultivars (Jambuarana and Nazareth), with six replications, two fertilization (organic and mineral) and two cultivars (Jambuarana and Nazareth). The following characteristics were evaluated: Plant height (cm), Leaf area (cm(2)), Fresh mass (g), Dry mass (g), Leaf area index (LAI), Leaf area ratio (LAR), Specific leaf Area (SLA), Leaf Weight Ratio (LWR), Amount of water in the plant (QAPA) (g per plant set), Leaf specific weight (LSW) (g cm(-2) per plant set) and Economic productivity. All data were statistically analyzed by analysis of variance and the Tukey test (1%) for mean comparison, with the software SISVAR. In the conditions of this experiment was carried out, it was possible to verify that the cultivar Jamburana had not only a good agronomic development and economic productivity under organic fertilization but also the best morpho-physiological indexes, showing that this kind of fertilization increases the agronomic effectiveness of this cultivar.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Matemática em Rede Nacional - IBILCE

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We present herein an experience report, followed by the analysis of some of its aspects. We discuss teacher’s education for the integration of Digital Technologies for Information and Communication (DTIC) in the teaching-learning process in public schools, based on actual practices experienced in extension projects developed at the Sao Paulo State University (UNESP). We aimed at providing a reflection on possible means for training of initial teachers in Basic Education for the use of technology, by assuming that it represents unique opportunity to investigate the process of learning the teaching process. The relevance of this discussion is not only to consider that teachers are essential for any novelty expected in education, but also as a reflection on the knowledge that teachers and initial teachers should have and need to overcome an old technology-mediated education.

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Pós-graduação em Psicologia - FCLAS

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Educação Matemática - IGCE

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Pós-graduação em Psicologia - FCLAS

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Chemical and physical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, the aim of this work was to study the stability of darunavir and to develop and validate a liquid chromatography (LC) method to determine darunavir in raw material and tablets in the presence of degradation products. The novel method showed to be linear from 6.0 to 21.0 μg/mL, with high precision (CV < 2%) and accuracy (recuperation of 99.64%). It is simple and reliable, free of placebo interferences. The robustness of the method was evaluated by a factorial design using seven different parameters. Forced degradation study was done under alkaline, acidic, and oxidative stress at ambient temperature and by heating. The LC method was able to quantify and separate darunavir and its degradation products. Darunavir showed to be unstable under alkaline, acid, and oxidative conditions. The novelty of this study is understanding the factors that affect darunavir ethanolate stability in tablets, which is the first step to unravel the path to know the degradation products. The novel stability-indicating method can be used to monitor the drug and the main degradation products in low concentrations in which there is linearity.

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The purpose of this paper is to propose a definition of the term “green/environmental innovation”, based on a systematic literature review. Design/methodology/approach– The literature review conducted in this research was based on papers published in ISI Web of Science and Scopus databases. Findings– Environmental innovations are organizational implementations and changes focusing on the environment, with implications for companies’ products, manufacturing processes and marketing, with different degrees of novelty. They can be merely incremental improvements that intensify the performance of something that already exists, or radical ones that promote something completely unprecedented, where the main objective is to reduce the company's environmental impacts. In addition, environmental innovation has a bilateral relationship with the level of proactive environmental management adopted by companies. Increasing of environmental innovation tends to come up against many barriers.

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Pós-graduação em Psicologia - FCLAS

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)