Interleukin-10 rs1800896 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock

Despite major improvements in its treatment and diagnosis, sepsis is still a leading cause of death and admittance to the intensive care unit (ICU). Failure to identify patients at high risk of developing septic shock contributes to an increase in the sepsis burden and rapid molecular tests are currently the most promising avenue to aid in patient risk determination and therapeutic anticipation. The primary goal of this study was to evaluate the genetic susceptibility that affects sepsis outcome in 72 sepsis patients admitted to the ICU. Seven polymorphisms were genotyped in key inflammatory response genes in sepsis, including tumour necrosis factor-α,interlelukin (IL)-1β, IL-10,IL-8, Toll-like receptor 4, CXCR1and CXCR2. The primary finding showed that patients who were homozygous for the major A allele in IL-10rs1800896 had almost five times higher chance to develop septic shock compared to heterozygotes. Similarly, selected clinical features and CXCR2rs1126579 single nucleotide polymorphisms modulated septic shock susceptibility without affecting survival. These data support the hypothesis that molecular testing has clinical usefulness to improve sepsis prognostic models. Therefore, enrichment of the ICU portfolio by including these biomarkers will aid in the early identification of sepsis patients who may develop septic shock.

[11 phot. de l'île d'Heligoland par Albert Meyer, Louis Koch (phot. à Brême), Jacob Kruss (phot. à Aeuckens) et G. Friederichs, Hof-Photograph, don Raoul de Clermont en 1886]

Donateur : Clermont, Raoul de (18..-19..?)

M. et madame Poincaré se rendant au guildhall [hôtel de ville de Londres, le 11 novembre 1919] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56903

Équipe [Royale] Union Saint-Gilloise, ([prix] Gondrand), Colombes, 9/11/19 : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56838

5-11-19, M. Clemenceau sort du fort de Kirchbach [avec M. Millerand] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56820

High interleukin-4 expression and interleukin-4 gene polymorphisms are associated with susceptibility to human paracoccidioidomycosis

Paracoccidioidomycosis (PCM) is caused by dimorphic fungi from theParacoccidioides brasiliensis complex. Previous studies have demonstrated that the severity of disease is associated with a T-helper 2 immune response characterised by high interleukin (IL)-4 production. In the present study we analysed two polymorphisms in the IL-4gene (-590 C/T and intron-3 microsatellite) in 76 patients with PCM and 73 control subjects from an endemic area. The production of IL-4 by peripheral blood mononuclear cells after antigen or phytohaemagglutinin stimulation was determined by ELISA. A significant correlation was observed between the RP2/RP2 intron-3 genotype and infection with Paracoccidioides sp.(p = 0.011), whereas the RP1/RP1 genotype was correlated with resistance. No significant correlation was observed for the IL-4promoter polymorphism. Furthermore, the low IL-4 expression observed in the control group compared with patients was associated with the RP1/RP1 genotype. These results suggest that IL-4polymorphisms might be associated with the ability of the host to control Paracoccidioides sp.infection. The relevance of this polymorphism is supported by the observation that patients with disease produce high levels of IL-4 following mitogen or antigen stimulation. The IL-4gene is located in the cytokine cluster region of chromosome 5 where other polymorphisms have also been described.

12/11/19, bateaux viviers à Paris : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56890

11/11/19, parc des Princes, rugby, équipe de l'U. S. Perpignanaise : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56881

5-11-19, M. Clemenceau [et M. Millerand] sur le pont du Rhin : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56816

5-11-19, M. Clemenceau [et M. Millerand] au pont de Kehl : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56815

5-11-19, M. Clemenceau au fort de Kirchbach : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56811

2-11-19, stade Bergeyre, équipe [de rugby de l'] Olympique [de Paris affrontant Biarritz] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56765

2-11-19, stade Bergeyre, équipe [de rugby de] Biarritz [affrontant l'Olympique de Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56763

1-11-19, [cimetière de] Bagneux, Toussaint [M. Poincaré et M. Raux, préfet de police] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56739

1-11-19, [cimetière américain de] Suresnes, fête des morts : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56738