O papel da ortodontia na correcção de más oclusões classe III com recurso à cirurgia ortognática

Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

Fundo Constitucional do Norte como mediador do desenvolvimento regional: o caso da mesorregião de Belém do Pará

Este artigo visa discutir a contribuição do Fundo Constitucional do Norte (FNO) ao desenvolvimento da mesorregião de Belém do Pará. Idealmente, o desenvolvimento de uma região deve gerar prosperidade às localidades do entorno, visando reduzir desigualdades sociais. Para tanto, é necessário o concurso de diferentes atores, com diferentes extensões de força. Há que se combinar o crescimento socioeconômico das localidades ao uso ecorresponsável dos recursos, bem como incluir a valorização do acervo natural e cultural que caracterizam a identidade da região. Este artigo foi desenvolvido a partir de uma pesquisa de caráter descritivo e os dados foram obtidos mediante pesquisa bibliográfica e documental. Os resultados do estudo indicam que, embora tenha sido uma fonte recorrente de financiamento das atividades econômicas regionais, o FNO, após 20 anos de sua implantação, não gerou patamares superiores de desenvolvimento regional. No que tange ao uso sustentável dos recursos naturais, mesmo após duas décadas de debate, observa-se que em uma das duas microrregiões estudadas, a sustentabilidade ambiental manteve-se ruim. Na região de maior volume de empréstimos, o desenvolvimento sustentável alcançou apenas o nível médio. Podemos verificar que não será em uma geração que o progresso econômico e social será alcançado na região, o que é compreensível face às disparidades históricas do desenvolvimento regional brasileiro e desigualdades sociais.

La inserción de los académicos jóvenes en la universidad argentina

El presente trabajo tiene el propósito de describir las características del proceso de inserción en la vida académica de los docentes universitarios en el último decenio, en universidades nacionales, indagando cuáles son sus percepciones sobre las principales problemáticas y desafíos que enfrentan en el primer tramo de su trayectoria laboral. El trabajo es producto de resultados de avance de dos proyectos: "La Profesión Académica en proceso de cambio" (PPUA-UNGS 2008) y el proyecto de beca de investigación "La inserción en la vida académica de las jóvenes generaciones" (UNGS 2010-2011), con el fin de combinar un enfoque cuantitativo basado en el análisis de una encuesta realizada a más de 800 académicos de todo el país, con un abordaje cualitativo, que utiliza como principales fuentes entrevistas en profundidad realizadas a académicos que obtuvieron su primer cargo a partir del año 2000.Se intentará indagar sobre las estrategias que despliegan los académicos más jóvenes en su adaptación a las nuevas condiciones del trabajo, en situaciones crecientemente competitivas para la inserción y la continuación en la carrera

Procedimientos de los investigadores de humanidades y ciencias sociales en la búsqueda de información

La búsqueda de información y sus problemas colaterales inciden en el desarrollo de la actividad de los investigadores. Nos proponemos analizar esta temática a través del estudio de las pautas de comportamiento de investigadores de la Facultad de Humanidades y Ciencias de la Educación de la Universidad de La Plata, para identificar conductas informativas y al mismo tiempo detectar obstáculos que impiden el aprovechamiento óptimo de la Biblioteca Central y las Bibliotecas Departamentales de la Institución. Los resultados obtenidos servirán de base para definir indicadores de calidad aplicables a la mejora continua de los servicios de biblioteca. Como resultado del análisis de metodologías aplicadas en estudios de usuarios se determinó combinar las perspectivas cuantitativa y cualitativa en este trabajo en curso

Sustentabilidade Empresarial: Um Estudo Comparativo Sobre o Desempenho e Valor Financeiro de Empresas Listadas no Mercado Acionário Brasileiro

Com o crescente aumento da cultura de proteção ambiental, o tema sustentabilidade vem ganhando cada vez mais espaço na vida das pessoas e principalmente na rotina das organizações. Existem algumas correntes teóricas propondo que para existir uma perenidade das organizações, estas devem incorporar em seu plano estratégico, todos os elementos que permitam um equilíbrio nas relações com os stakeholders. Já outras linhas teóricas, defendem que as empresas devem focar todos seus esforços para atender os acionistas (shareholders), maximizando os lucros e agregando valor. Neste contexto, alguns índices de sustentabilidade foram surgindo mundo afora, visando combinar com a já presente visão de resultados financeiros das organizações, também o alcance do bem estar para a sociedade e proteção do meio ambiente. No Brasil, em Novembro de 2005, foi lançando o ISE Índice de Sustentabilidade Empresarial, que foi desenvolvido para uma gama de empresas que apresentam boas práticas de sustentabilidade. Surge, então, o questionamento se a adoção das práticas de sustentabilidade pode de alguma forma, proporcionar melhor desempenho financeiro para as organizações que as adotam, pois de acordo com a teoria dos stakeholders, as instituições que conseguem atender as necessidades das partes interessadas têm seu valor maximizado ao longo do tempo. Com relação a isto, este presente estudo procura averiguar se as empresas que estão listadas no ISE, excluindo as empresas do setor de materiais básicos, utilidade pública, e financeiro, do período de 2006 a 2008, desenvolveram desempenho financeiro superior às outras empresas que não fazem parte do índice no mesmo período. Foram selecionados dados secundários, utilizando a base de dados da Economática, criando dois grupos para comparação, onde um grupo consta de empresas que estão exclusivamente listadas no ISE, consideradas sustentáveis e outro grupo de empresas, formado por empresas listadas no IBOVESPA e que não participaram do ISE. Tomando o Q de Tobin como a variável dependente e índices de Tamanho da Empresa, Distribuição de Dividendos, Debt to Equity, ROA, Crescimento de Vendas, Crescimento dos Investimentos, Diversificação de Mercado, Endividamento como variáveis independentes, foram aplicados testes estatísticos comparando as médias dos índices, seguido do teste t de student, e regressões de dados em painel pooled, fixed e random effects para encontrar a possível correlação entre sustentabilidade e valor da empresa. Os resultados encontrados apontam uma relação entre sustentabilidade empresarial e desempenho financeiro.(AU)

CONSCIÊNCIA E EMOÇÃO: O EFEITO DO PRIMING AFETIVO SUBLIMINAR EM TAREFAS DE ATENÇÃO

Esta tese revisou duas linhas de pesquisa, desenvolvidas nas últimas décadas: o estudo de efeitos de estimulação subliminar priming , e de desencadeamento de reações emocionais por estímulos controlados. Este estudo tem o objetivo de combinar tais linhas para o estudo da consciência com pré-preparo afetivo: efeito de estímulos de conteúdo aversivo, subliminares e supraliminares, sobre a cognição, pela análise do desempenho em tarefa de atenção. Três tarefas experimentais foram realizadas por 35 indivíduos em laboratório de neuropsicologia: a tarefa base onde testamos à detecção de alvo visual simples, e a mesma tarefa de base, porém com estímulos distratores aversivos intercalados, de forma supraliminar ou subliminar (500 ms ou 50 ms de duração), em blocos aleatorizados entre os indivíduos. Calcularam-se índices de detectabilidade e critério de resposta, que serviram para a comparação estatística entre condições (medidas repetidas). Os resultados mostram uma mudança significativa do índice critério , indicando mudança de estratégia na presença de distratores subliminares aversivos. Concluiu-se que a tarefa subliminar fez um efeito destruidor ou devastador na tarefa supraliminar, cometendo menos falso-alarmes protegendo a tarefa supraliminar, tendo um efeito protetor . Os resultados são discutidos no contexto da relevância de influências emocionais sobre o comportamento para a Psicologia da Saúde.

Xilanas de sabugo de milho como agente antioxidante, citotóxico, anticoagulante e imunomodulador

Prospecting pharmacological active polysaccharides from agricultural byproducts, such as corncobs, is an underexplored practice in the scientific community. Thus, this work aims to expand knowledge about pharmacological activities of polysaccharides extracted from corncobs. From corn cob flour a extract was obtained by ultrasound waves in an alkaline medium, and the end of the process the product was termed PECC (polysaccharidic extract from corncobs). This extract was physicochemical characterized and evaluated by in vitro assays as an antioxidant, cytotoxic, anticoagulant and imunomodulator agent. Results indicated significant activity metal chelating by PECC, and the use of PECC in cell culture cells showed no toxic effects to normal cell lines, but toxic action against HeLa tumor cells due promoting cell death by apoptosis. In addition, other pharmacological effects were observed, the PECC decreased nitric oxide (NO) production by activated macrophages, and prolonged blood clotting time through APTT assay. Then methanolic, ethanolic and ketone fractions were obtained from fractionation of PECC polysaccharides. Five methanolic fractions, six ethanolic fractions and two ketones were obtained; and all fractions were evaluated for antioxidant, cytotoxic, anticoagulant, immunomodulatory activities. E1.4 fraction exhibited significant metal chelating effect, a toxic action to induce apoptosis in HeLa cells, decreased NO production by activated macrophages, and extended blood clotting time. These results showed that the PECC pharmacological active polysaccharides would be present in the fraction E1.4. From fractionation of E1.4 polysaccharide six subfractions with different sizes were obtained: <3; 3-10; 10-30; 30-50; 50-100 and >100 KDa. About 80% of E1.4 polysaccharides had lower size to 10 KDa, and all the subfractions showed over 61% sugar in their chemical compositions. These subfractions exhibited different monosaccharide compositions, but xylose was presented in all of them. The subfractions exhibited distinct pharmacological effects in in vitro assays. Smaller subfractions (<30 KDa) had highest metal chelating activity and greater toxic action in tumor cells. The intermediate fractions (between 30-100 KDa) decreased more NO production of activated macrophages, for other side, the larger size (>100 KDa) modulated a greater number of inflammatory cytokines, and the had greatest anticoagulant effect. Therefore, when analyzing all the results together it is evident that the PECC pharmacological polysaccharides are heteroxylans, and were concentrated in E1.4 fraction, and heteroxilanas pharmacological effects depends on their molecular size. Thus, corncobs could be used as source from molecules with biotechnology potential

Infoestrutura: um sistema em nuvem para prover contexto como serviço no cenário de internet das coisas integrado a ambientes veiculares

Through numerous technological advances in recent years along with the popularization of computer devices, the company is moving towards a paradigm “always connected”. Computer networks are everywhere and the advent of IPv6 paves the way for the explosion of the Internet of Things. This concept enables the sharing of data between computing machines and objects of day-to-day. One of the areas placed under Internet of Things are the Vehicular Networks. However, the information generated individually for a vehicle has no large amount and does not contribute to an improvement in transit, once information has been isolated. This proposal presents the Infostructure, a system that has to facilitate the efforts and reduce costs for development of applications context-aware to high-level semantic for the scenario of Internet of Things, which allows you to manage, store and combine the data in order to generate broader context. To this end we present a reference architecture, which aims to show the major components of the Infostructure. Soon after a prototype is presented which is used to validate our work reaches the level of contextualization desired high level semantic as well as a performance evaluation, which aims to evaluate the behavior of the subsystem responsible for managing contextual information on a large amount of data. After statistical analysis is performed with the results obtained in the evaluation. Finally, the conclusions of the work and some problems such as no assurance as to the integrity of the sensory data coming Infostructure, and future work that takes into account the implementation of other modules so that we can conduct tests in real environments are presented.

Novas abordagens para configurações automáticas dos parâmetros de controle em comitês de classificadores

Significant advances have emerged in research related to the topic of Classifier Committees. The models that receive the most attention in the literature are those of the static nature, also known as ensembles. The algorithms that are part of this class, we highlight the methods that using techniques of resampling of the training data: Bagging, Boosting and Multiboosting. The choice of the architecture and base components to be recruited is not a trivial task and has motivated new proposals in an attempt to build such models automatically, and many of them are based on optimization methods. Many of these contributions have not shown satisfactory results when applied to more complex problems with different nature. In contrast, the thesis presented here, proposes three new hybrid approaches for automatic construction for ensembles: Increment of Diversity, Adaptive-fitness Function and Meta-learning for the development of systems for automatic configuration of parameters for models of ensemble. In the first one approach, we propose a solution that combines different diversity techniques in a single conceptual framework, in attempt to achieve higher levels of diversity in ensembles, and with it, the better the performance of such systems. In the second one approach, using a genetic algorithm for automatic design of ensembles. The contribution is to combine the techniques of filter and wrapper adaptively to evolve a better distribution of the feature space to be presented for the components of ensemble. Finally, the last one approach, which proposes new techniques for recommendation of architecture and based components on ensemble, by techniques of traditional meta-learning and multi-label meta-learning. In general, the results are encouraging and corroborate with the thesis that hybrid tools are a powerful solution in building effective ensembles for pattern classification problems.

Estudo do balanço de umidade por meio de modelos regionais para o clima do passado e do futuro sobre a América do Sul

In the context of climate change over South America (SA) has been observed that the combination of high temperatures and rain more temperatures less rainfall, cause different impacts such as extreme precipitation events, favorable conditions for fires and droughts. As a result, these regions face growing threat of water shortage, local or generalized. Thus, the water availability in Brazil depends largely on the weather and its variations in different time scales. In this sense, the main objective of this research is to study the moisture budget through regional climate models (RCM) from Project Regional Climate Change Assessments for La Plata Basin (CLARIS-LPB) and combine these RCM through two statistical techniques in an attempt to improve prediction on three areas of AS: Amazon (AMZ), Northeast Brazil (NEB) and the Plata Basin (LPB) in past climates (1961-1990) and future (2071-2100). The moisture transport on AS was investigated through the moisture fluxes vertically integrated. The main results showed that the average fluxes of water vapor in the tropics (AMZ and NEB) are higher across the eastern and northern edges, thus indicating that the contributions of the trade winds of the North Atlantic and South are equally important for the entry moisture during the months of JJA and DJF. This configuration was observed in all the models and climates. In comparison climates, it was found that the convergence of the flow of moisture in the past weather was smaller in the future in various regions and seasons. Similarly, the majority of the SPC simulates the future climate, reduced precipitation in tropical regions (AMZ and NEB), and an increase in the LPB region. The second phase of this research was to carry out combination of RCM in more accurately predict precipitation, through the multiple regression techniques for components Main (C.RPC) and convex combination (C.EQM), and then analyze and compare combinations of RCM (ensemble). The results indicated that the combination was better in RPC represent precipitation observed in both climates. Since, in addition to showing values be close to those observed, the technique obtained coefficient of correlation of moderate to strong magnitude in almost every month in different climates and regions, also lower dispersion of data (RMSE). A significant advantage of the combination of methods was the ability to capture extreme events (outliers) for the study regions. In general, it was observed that the wet C.EQM captures more extreme, while C.RPC can capture more extreme dry climates and in the three regions studied.

Materiais bionanocompósitos a base de argilominerais e hidróxidos duplos lamelares como sistemas de liberação de fármacos

Bionanocomposites systems clay base (montmorillonite and sepiolite), layered double hidroxides and biopolymers (carboxymethylcellulose and zein) were evaluated as topical delivery systems with antibacterial activity and as oral delivery systems. For this study, neomycin, a topical antibiotic, indicated mainly for open wound infections. The drug amoxicillin, an antibiotic indicated mainly for throat infections, were also used in this study. Both antibiotics were used as model drugs. Initially, drugs were incorporated directly into the biopolymer matrix, comprising the combination of carboxymethylcellulos and zein, being conformed as movies and balls and evaluated for their antibacterial activity and controlled release simulating gastrointestinal fluids. Moreover, hybrids materials have been prepared where the neomycin drug was incorporated into the lamellar inorganic solids, such as montmorillonite by ion exchange reaction, and the fibrous type, such as sepiolite by adsorption in aqueous solution. But the drug amoxicillin was incorporated into layered double hydroxides by anion exchange and montmorillonite by cation exchange. The resulting hybrids were in turn combined with the biopolymer matrix yielding bionanocomposites shaped materials such as films were tested for their antibacterial activity, and the shaped materials beads were tested for their release in the gastrointestinal fluids. Through the analysis of various physico-chemical techniques, we observed the interactions between the studied materials, the formation of hybrids materials, obtaining the bionanocomposites materials and material efficiency when applied in controlled release of drugs both topical and use oral mainly influenced by the presence of zein, are promising as topical delivery systems and oral drugs.

Influência da interação dipolar nas fases magnéticas de nanopartículas esféricas com estrutura núcleo@camada

Bi-magnetic core@shell nanoparticle has attracted attention several researchers because great applicability that they offer. The possibility of combining different functionalities of magnetic materials make them a key piece in many areas as in data processing permanent magnets and biomagnetics sistems. These nanoparticles are controlled by intrinsic properties of the core and shell materials as well as the interactions between them, besides size and geometry effects. Thus, it was developed in this thesis a theoretical study about dipolar interaction contribution between materials different magnetic properties in bi-magnetic core@shell nanoparticles conventional spherical geometry. The materials were analyzed CoFe2O4, MnFe2O4 e CoFe2 in various combinations and sizes. The results show that the impact of the core dipole field in the shell cause reverse magnetization early its, before of the core, in nanoparticle of CoFe2O4(22nm)@CoFe2(2nm), thereby causing a decrease coercivity field of 65% in comparection with simple nanoparticle of CoFe2O4 (HC=13.6 KOe) of same diameter. The large core anisotropy in conventional nanoparticle makes it the a stable dipolar field source in the shell, that varies length scale of the order of the core radius. Furthermore, the impact of dipolar field is greatly enhanced by the geometrical constraints and by magnetics properties of both core@shell materials. In systems with core coated with a thin shell of thickness less than the exchange length, the interaction interface can hold reversal the shell occurring an uniform magnetization reversal, however this effect only is relevant on systems where the dipole field effects is weak compared with the exchange interaction.

Influência da interação dipolar nas fases magnéticas de nanopartículas esféricas com estrutura núcleo@camada

Bi-magnetic core@shell nanoparticle has attracted attention several researchers because great applicability that they offer. The possibility of combining different functionalities of magnetic materials make them a key piece in many areas as in data processing permanent magnets and biomagnetics sistems. These nanoparticles are controlled by intrinsic properties of the core and shell materials as well as the interactions between them, besides size and geometry effects. Thus, it was developed in this thesis a theoretical study about dipolar interaction contribution between materials different magnetic properties in bi-magnetic core@shell nanoparticles conventional spherical geometry. The materials were analyzed CoFe2O4, MnFe2O4 e CoFe2 in various combinations and sizes. The results show that the impact of the core dipole field in the shell cause reverse magnetization early its, before of the core, in nanoparticle of CoFe2O4(22nm)@CoFe2(2nm), thereby causing a decrease coercivity field of 65% in comparection with simple nanoparticle of CoFe2O4 (HC=13.6 KOe) of same diameter. The large core anisotropy in conventional nanoparticle makes it the a stable dipolar field source in the shell, that varies length scale of the order of the core radius. Furthermore, the impact of dipolar field is greatly enhanced by the geometrical constraints and by magnetics properties of both core@shell materials. In systems with core coated with a thin shell of thickness less than the exchange length, the interaction interface can hold reversal the shell occurring an uniform magnetization reversal, however this effect only is relevant on systems where the dipole field effects is weak compared with the exchange interaction.

Estudo da injeção de água e gás em um reservatório com características do pré-sal brasileiro

The pre-salt province is composed by large amounts of light oil and with good quality, a reality that puts Brazil in a strategic position facing the great demand for energy worldwide. In this province are the largest discoveries in the world in the last ten years; areas as Libra, Franco and Lula field, everyone containing volumes greater than 8 billion recoverable oil barrels. To develop and optimize the production of these fields, a study was done for choosing the improved oil recovery methods. The main motivations were the presence of carbon dioxide (CO2) as a contaminant and the strategic decision of do not discard it, combined with high GOR (gas-oil ratio) of the reservoir fluid. The method should take advantage of the unique abundant resources: seawater and produced gas. This way, the process of matching these resources in the water alterning gas injection (WAG) became a good option. In this master’s dissertation, it was developed a reservoir model with average characteristics of the Brazilian pre-salt, where was applied the improved oil recovery method of water alternating gas. The production of this reservoir was analyzed by parameters as: the first fluid injected in the injection process, position of the injection wells completion, injection water and gas rate and cycle time. The results showed a good performance of the method, with up to 26% of gains in the recovery factor regarding the primary recovery, since the application of water injection and gas, individually, was not able to overcome 10 % of gain. The most influential parameter found in the results was the cycle time, with higher recovery factor values obtained with the use of shorter times.

Corpus annotation of causal relations and their signals in English and Spanish

El estudio de las relaciones causales y su expresión lingüística ha sido comúnmente estudiado desde diferentes perspectivas en los años recientes. Sin embargo, pocos estudios han intentado combinar diferentes enfoques para establecer el significado de estas relaciones, y han investigado de manera contrastiva las señales usadas para expresarlas. Este trabajo de fin de master es un proyecto para avanzar el conocimiento en este área mediante la investigación de: a) la posibilidad de caracterizar las relaciones causales en diferentes tipos, usando características que combinan un enfoque funcional y cognitivo; b) los tipos de relaciones causales preferidas en los textos expositivos en inglés y sus traducciones al español; c) las expresiones lingüísticas preferidas para expresar dichas relaciones causales en los textos originales en inglés y sus traducciones al español. La metodología usada en esta investigación se basa en la anotación manual de un corpus bilingüe compuesto de un total de 37 textos expositivos (incluyendo los textos originales en inglés y sus traducciones al español) extraídos del corpus MULTINOT, un corpus de alta calidad, con registros diversificados y multifuncional bilingüe inglésespañol, actualmente compilado y anotado multidimensionalmente por los miembros del grupo de investigación FUNCAP con el proyecto MULTINOT (véase Lavid et al.2015) El estudio se llevó a cabo en cuatro pasos principales: primero, un esquema de anotación para las relaciones causales en inglés y español fue diseñado constando de tres sistemas interrelacionados y sus correspondientes características; tras ello, se compiló un inventario de señales para las relaciones causales en inglés y español, y una categorización en diferentes tipos; seguidamente, el esquema de anotación fue implementado en la herramienta UAM Corpus Tool y el conjunto de textos bilingües fue anotado por el autor de este estudio; finalmente, los datos extraídos de la anotación fueron analizados estadísticamente para comprobar las posibles diferencias entre los textos originales en inglés y sus traducciones al español respecto a la selección del tipo de relación de causa y sus señales. El análisis estadístico de los datos anotados sugiere que los tipos de relaciones de causa preferidos en los textos originales en inglés y son los tipos de contenido y no volitivos, que el orden de aparición de estos tipos de señales preferido es la segunda posición, y las señales más recurrentes usadas para expresar dichas relaciones son las conjunciones, seguidas de los sintagmas verbales. El análisis de las traducciones al español revela un alto grado de similitud con los datos de los textos originales en inglés, lo que sugiere que en las traducciones al español se conservan las preferencias de los textos originales en la mayoría de los casos y que estas elecciones pueden considerarse un indicativo de los textos expositivos en inglés. Proyectos futuros se centraran en el análisis de los textos originales en español para comprobar si las tendencias observadas en los textos originales en inglés y sus traducciones al español son también validas en textos originales en español, y en la especificación de patrones que puede ayudar al análisis automático de estas relaciones