Individual Classification of Mild Cognitive Impairment Subtypes by Support Vector Machine Analysis of White Matter DTI.

BACKGROUND AND PURPOSE: MCI was recently subdivided into sd-aMCI, sd-fMCI, and md-aMCI. The current investigation aimed to discriminate between MCI subtypes by using DTI. MATERIALS AND METHODS: Sixty-six prospective participants were included: 18 with sd-aMCI, 13 with sd-fMCI, and 35 with md-aMCI. Statistics included group comparisons using TBSS and individual classification using SVMs. RESULTS: The group-level analysis revealed a decrease in FA in md-aMCI versus sd-aMCI in an extensive bilateral, right-dominant network, and a more pronounced reduction of FA in md-aMCI compared with sd-fMCI in right inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The comparison between sd-fMCI and sd-aMCI, as well as the analysis of the other diffusion parameters, yielded no significant group differences. The individual-level SVM analysis provided discrimination between the MCI subtypes with accuracies around 97%. The major limitation is the relatively small number of cases of MCI. CONCLUSIONS: Our data show that, at the group level, the md-aMCI subgroup has the most pronounced damage in white matter integrity. Individually, SVM analysis of white matter FA provided highly accurate classification of MCI subtypes.

Improving Transition Outcomes: Henry County Transition Partners: Infrastructure Building Replication Template

Replication Template for Improving Transition Outcomes Henry County Transition Partners Prototype. This concise document will help you build a community team and the infrastructure necessary to implement and plan for sustaining specific initiatives.

Improving Transition Outcomes: Henry County Transition Partners: Guidebook Part 1

Part 1 of 7 for Henry County's Transition Partners Guidebook specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Guidebook Part 2

Part 2 of 7 for Henry County's Transition Partners Guidebook specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Guidebook Part 3

Part 3 of 7 for Henry County's Transition Partners Guidebook specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Guidebook Part 4

Part 4 of 7 for Henry County's Transition Partners Guidebook specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Guidebook Part 5

Part 5 of 7 for Henry County's Transition Partners Guidebook specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Trabecular bone score is associated with volumetric bone density and microarchitecture as assessed by central QCT and HRpQCT in Chinese American and white women.

Although high-resolution peripheral quantitative computed tomography (HRpQCT) and central quantitative computed tomography (QCT) studies have shown bone structural differences between Chinese American (CH) and white (WH) women, these techniques are not readily available in the clinical setting. The trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry spine images. We assessed TBS in CH and WH women and investigated whether TBS is associated with QCT and HRpQCT indices. Areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry, lumbar spine (LS) TBS, QCT of the LS and hip, and HRpQCT of the radius and tibia were performed in 71 pre- (37 WH and 34 CH) and 44 postmenopausal (21 WH and 23 CH) women. TBS did not differ by race in either pre- or postmenopausal women. In the entire cohort, TBS positively correlated with LS trabecular volumetric bone mineral density (vBMD) (r = 0.664), femoral neck integral (r = 0.651), trabecular (r = 0.641) and cortical vBMD (r = 0.346), and cortical thickness (C/I; r = 0.540) by QCT (p < 0.001 for all). TBS also correlated with integral (r = 0.643), trabecular (r = 0.574) and cortical vBMD (r = 0.491), and C/I (r = 0.541) at the total hip (p < 0.001 for all). The combination of TBS and LS aBMD predicted more of the variance in QCT measures than aBMD alone. TBS was associated with all HRpQCT indices (r = 0.20-0.52) except radial cortical thickness and tibial trabecular thickness. Significant associations between TBS and measures of HRpQCT and QCT in WH and CH pre- and postmenopausal women demonstrated here suggest that TBS may be a useful adjunct to aBMD for assessing bone quality.

Improving Transition Outcomes: Henry County Transition Partners: Guidebook Part 6

Part 6 of 7 for Henry County's Transition Partners Guidebook specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Directory Part 1

Part 1 of 3 for Henry County's Transition Partners Resource Directory specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Directory Part 2

Part 2 of 3 for Henry County's Transition Partners Resource Directory specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners: Directory Part 3

Part 3 of 3 for Henry County's Transition Partners Resource Directory specific to youth with disabilities transitioning from high school to employment, post-secondary education, or adult services.

Improving Transition Outcomes: Henry County Transition Partners Prototype: General Information

General information on the Henry County Transition Partners community prototype under Improving Transition Outcomes with Iowa Vocational Rehabilitation Services.

Improving Transition Outcomes: Henry County Transition Partners: Youth Interview Invitation

Henry County's Transition Partners' youth focus group interview invitation.