Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill.

BACKGROUND Apoptosis is a key mechanism involved in ischemic acute kidney injury (AKI), but its role in septic AKI is controversial. Biomarkers indicative of apoptosis could potentially detect developing AKI prior to its clinical diagnosis. METHODS As a part of the multicenter, observational FINNAKI study, we performed a pilot study among critically ill patients who developed AKI (n = 30) matched to critically ill patients without AKI (n = 30). We explored the urine and plasma levels of cytokeratin-18 neoepitope M30 (CK-18 M30), cell-free DNA, and heat shock protein 70 (HSP70) at intensive care unit (ICU) admission and 24h thereafter, before the clinical diagnosis of AKI defined by the Kidney Disease: Improving Global Outcomes -creatinine and urine output criteria. Furthermore, we performed a validation study in 197 consecutive patients in the FINNAKI cohort and analyzed the urine sample at ICU admission for CK-18 M30 levels. RESULTS In the pilot study, the urine or plasma levels of measured biomarkers at ICU admission, at 24h, or their maximum value did not differ significantly between AKI and non-AKI patients. Among 20 AKI patients without severe sepsis, the urine CK-18 M30 levels were significantly higher at 24h (median 116.0, IQR [32.3-233.0] U/L) than among those 20 patients who did not develop AKI (46.0 [0.0-54.0] U/L), P = 0.020. Neither urine cell-free DNA nor HSP70 levels significantly differed between AKI and non-AKI patients regardless of the presence of severe sepsis. In the validation study, urine CK-18 M30 level at ICU admission was not significantly higher among patients developing AKI compared to non-AKI patients regardless of the presence of severe sepsis or CKD. CONCLUSIONS Our findings do not support that apoptosis detected with CK-18 M30 level would be useful in assessing the development of AKI in the critically ill. Urine HSP or cell-free DNA levels did not differ between AKI and non-AKI patients.

Documents relative to the colonial history of the state of New-York : procured in Holland, England, and France /

Includes index.

Out of the past: (critical and literary papers)

Bryant's poems.--Jeremy Bentham and law reform.--Edward Livingston and his code.--Journalism.--John James Audubon.--Percy Bysshe Shelley.--The last half-century.--American authorship.--Alison's histories of Europe.--The "Works" of American statesmen.--Comte's philosophy.--Strauss's Life of Jesus.--The late Horace Binney Wallace.--Thackeray as novelist.--Goethe.--Ruskin's writings.--Causes of the French revolution.--Motley's Rise of the Dutch republic.--Emerson on England.

Annual report ... including the annual registration report.

1921-1931/32 published only in the Annual report of the Health Department; 1933- also included in that report.

The pathology of the vitamin B complex deficiencies in the chicken.

This essay won the Poultry Disease Essay contest for 1949.

Heat stroke and the effects of heat stress in the fowl.

Cowinner in the Poultry Disease Essay Contest, 1961.

X disease in chickens ...

Paper submitted in competition for the poultry disease essay award for the year 1951-1952.

International competition of the Carnegie Foundation : the Palace of Peace at the Hague : the 6 premiated and 40 other designs chosen by the Society of Architecture at Amsterdam and reproduced under its direction.

Vignette by K. Sluyterman on portfolio cover, fasc. wrappers, and t.p.

Catalogue of the described Diptera from South Asia /

Includes index.

The works of John Marston.

With several reproductions of original title-pages.

The writings of John Lothrop Motley.

"This edition limited to 500 sets."

The memorial history of the City of New-York, from its first settlement to the year 1892.

seventeenth century. Hildeburn, C.R. Printing in New-York in the seventeenth century. Table of dates in New-York history.--v. 2. Vermilye, A.G. The Earl of Bellemont and suppression of piracy, 1698-1701. Stone, W.L. The administration of Lord Cornbury, 1702-1708. Wilson, J.G. Lord Lovelace and the second Canadian campaign, 1708-1710.

Holstein herd-book, containing a record of all Holstein cattle in America, approved and admitted for registry ... under the by-laws and resolutions of the Holstein breeders' association of America.

In 1885 the association united with the Dutch-Friesian association of America to form the Holstein-Friesian association of America, which see for continuation of herd book.

The history of Java.

Gives an account of the Dutch East India Company.

Lord Milner's work in South Africa : from its commencement in 1897 to the peace of Vereeniging in 1902 containing hitherto unpublished information /

"First edition, November 1906. Reprinted before publication."