Breviarum romanum : cum numeris in margine, psalmorum, hymnorum, antiphonarum... ([Reprod.]) / Leonem X approbatum

[Bréviaire (latin). 1526]

Low-molecular-weight or unfractionated heparin in venous thromboembolism: the influence of renal function.

BACKGROUND: In patients with acute venous thromboembolism and renal insufficiency, initial therapy with unfractionated heparin may have some advantages over low-molecular-weight heparin. METHODS: We used the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) Registry data to evaluate the 15-day outcome in 38,531 recruited patients. We used propensity score matching to compare patients treated with unfractionated heparin with those treated with low-molecular-weight heparin in 3 groups stratified by creatinine clearance levels at baseline: >60 mL/min, 30 to 60 mL/min, or <30 mL/min. RESULTS: Patients initially receiving unfractionated heparin therapy (n = 2167) more likely had underlying diseases than those receiving low-molecular-weight heparin (n = 34,665). Propensity score-matched groups of patients with creatinine clearance levels >60 mL/min (n = 1598 matched pairs), 30 to 60 mL/min (n = 277 matched pairs), and <30 mL/min (n = 210 matched pairs) showed an increased 15-day mortality for unfractionated heparin compared with low-molecular-weight heparin (4.5% vs 2.4% [P = .001], 5.4% vs 5.8% [P = not significant], and 15% vs 8.1% [P = .02], respectively), an increased rate of fatal pulmonary embolism (2.8% vs 1.2% [P = .001], 3.2% vs 2.5% [P = not significant], and 5.7% vs 2.4% [P = .02], respectively), and a similar rate of fatal bleeding (0.3% vs 0.3%, 0.7% vs 0.7%, and 0.5% vs 0.0%, respectively). Multivariate analysis confirmed that patients treated with unfractionated heparin were at increased risk for all-cause death (odds ratio, 1.8; 95% confidence interval, 1.3-2.4) and fatal pulmonary embolism (odds ratio, 2.3; 95% confidence interval, 1.5-3.6). CONCLUSIONS: In comparison with low-molecular-weight heparin, initial therapy with unfractionated heparin was associated with a higher mortality and higher rate of fatal pulmonary embolism in patients with creatinine clearance levels >60 mL/min or <30 mL/min, but not in those with levels between 30 and 60 mL/min.

Access to Justice och domstolarnas roll i framtiden

Kirjoitus perustuu Suomalaisen Lakimiesyhdistyksen Lakimiespäivillä 5.10.2002 pidettyyn esitykseen

Tadpole pupil.

Editors' Note: Dr. Egan inquires about the possibility of Tournay phenomenon in Kawasaki and Mayer's "Tadpole pupil." Dr. Charles, in reference to "Disease-modifying drugs for multiple sclerosis in pregnancy: A systematic review," suggests that it might be appropriate to continue glatiramer acetate in women trying to conceive given the lack of evidence of fetal risk. Authors Tremlett et al. advise that, at this point, each case should continue to be assessed individually.

Antiikin vaikutus Italian renessanssiin

Kirjoittaja on fil. tri ja museoviraston pääjohtaja. Kirjoitus perustuu esitelmään Tieteen päivillä 8.-12.1.2003.

Kielentutkimus ja äidinkieli

Virkaanastujaisesitelmä Helsingin yliopistossa 4. joulukuuta 2002

Pelinappula vai riskipeluri? : tulkintoja Suomesta toisen maailmansodan aikana

Kirjoitus perustuu Tieteiden yönä Tieteiden talolla 9.1. pidettyyn esitelmään Tieteen päivillä (8.-12.1.2003).

Lähdeluettelojen ja kalkkilaastiajoituksen ongelmat

Åsa Ringbom julkaisi vastineen (Tieteessä tapahtuu 3/2004) vastineeseen, jonka Markus Hiekkanen oli kirjoittanut Henrik Liliuksen kirja-arvostelusta (TT1/2004)