Geología agrícola : provincia de Guipúzcoa. Primera parte, Bosquejo petrográfico / por Ramón Adán de Yarza.

Digitalización Vitoria-Gasteiz Fundación Sancho el Sabio 2008

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes

Mutations in the TP53 gene are very common in human cancers, and are associated with poor clinical outcome. Transgenic mouse models lacking the Trp53 gene or that express mutant Trp53 transgenes produce tumours with malignant features in many organs. We previously showed the transcriptome of a p53-deficient mouse skin carcinoma model to be similar to those of human cancers with TP53 mutations and associated with poor clinical outcomes. This report shows that much of the 682-gene signature of this murine skin carcinoma transcriptome is also present in breast and lung cancer mouse models in which p53 is inhibited. Further, we report validated gene-expression-based tests for predicting the clinical outcome of human breast and lung adenocarcinoma. It was found that human patients with cancer could be stratified based on the similarity of their transcriptome with the mouse skin carcinoma 682-gene signature. The results also provide new targets for the treatment of p53-defective tumours.

Historia de Vizcaya : general de todo el Señorío y particular de cada una de las anteiglesias, villas, ciudad, concejos y valles, desde su fundación hasta el año 1885 / escrita hasta el año 1787 por Juan Ramón de Iturriza y Zabala, y ampliada hasta nuestr

CLU CLU

Nuevas cubiertas de madera para la iglesia de San Martín en Jiménez de Jamúz (León)

Nuevas cubiertas de madera para a iglesia de San Martín en Jiménez de Jamúz (León)

Auto-localization algorithm for local positioning systems

This paper studies the problem of determining the position of beacon nodes in Local Positioning Systems (LPSs), for which there are no inter-beacon distance measurements available and neither the mobile node nor any of the stationary nodes have positioning or odometry information. The common solution is implemented using a mobile node capable of measuring its distance to the stationary beacon nodes within a sensing radius. Many authors have implemented heuristic methods based on optimization algorithms to solve the problem. However, such methods require a good initial estimation of the node positions in order to find the correct solution. In this paper we present a new method to calculate the inter-beacon distances, and hence the beacons positions, based in the linearization of the trilateration equations into a closed-form solution which does not require any approximate initial estimation. The simulations and field evaluations show a good estimation of the beacon node positions.

Error estimation for the linearized auto-localization algorithm

The Linearized Auto-Localization (LAL) algorithm estimates the position of beacon nodes in Local Positioning Systems (LPSs), using only the distance measurements to a mobile node whose position is also unknown. The LAL algorithm calculates the inter-beacon distances, used for the estimation of the beacons’ positions, from the linearized trilateration equations. In this paper we propose a method to estimate the propagation of the errors of the inter-beacon distances obtained with the LAL algorithm, based on a first order Taylor approximation of the equations. Since the method depends on such approximation, a confidence parameter τ is defined to measure the reliability of the estimated error. Field evaluations showed that by applying this information to an improved weighted-based auto-localization algorithm (WLAL), the standard deviation of the inter-beacon distances can be improved by more than 30% on average with respect to the original LAL method.

Improved heuristic drift elimination with magnetically-aided dominant directions (MiHDE) for pedestrian navigation in complex buildings

The main problem of pedestrian dead-reckoning (PDR) using only a body-attached inertial measurement unit is the accumulation of heading errors. The heading provided by magnetometers in indoor buildings is in general not reliable and therefore it is commonly not used. Recently, a new method was proposed called heuristic drift elimination (HDE) that minimises the heading error when navigating in buildings. It assumes that the majority of buildings have their corridors parallel to each other, or they intersect at right angles, and consequently most of the time the person walks along a straight path with a heading constrained to one of the four possible directions. In this article we study the performance of HDE-based methods in complex buildings, i.e. with pathways also oriented at 45°, long curved corridors, and wide areas where non-oriented motion is possible. We explain how the performance of the original HDE method can be deteriorated in complex buildings, and also, how severe errors can appear in the case of false matches with the building's dominant directions. Although magnetic compassing indoors has a chaotic behaviour, in this article we analyse large data-sets in order to study the potential use that magnetic compassing has to estimate the absolute yaw angle of a walking person. Apart from these analysis, this article also proposes an improved HDE method called Magnetically-aided Improved Heuristic Drift Elimination (MiHDE), that is implemented over a PDR framework that uses foot-mounted inertial navigation with an extended Kalman filter (EKF). The EKF is fed with the MiHDE-estimated orientation error, gyro bias corrections, as well as the confidence over that corrections. We experimentally evaluated the performance of the proposed MiHDE-based PDR method, comparing it with the original HDE implementation. Results show that both methods perform very well in ideal orthogonal narrow-corridor buildings, and MiHDE outperforms HDE for non-ideal trajectories (e.g. curved paths) and also makes it robust against potential false dominant direction matchings.

Accurate pedestrian indoor navigation by tightly coupling foot-mounted IMU and RFID measurements

We present a new method to accurately locate persons indoors by fusing inertial navigation system (INS) techniques with active RFID technology. A foot-mounted inertial measuring units (IMUs)-based position estimation method, is aided by the received signal strengths (RSSs) obtained from several active RFID tags placed at known locations in a building. In contrast to other authors that integrate IMUs and RSS with a loose Kalman filter (KF)-based coupling (by using the residuals of inertial- and RSS-calculated positions), we present a tight KF-based INS/RFID integration, using the residuals between the INS-predicted reader-to-tag ranges and the ranges derived from a generic RSS path-loss model. Our approach also includes other drift reduction methods such as zero velocity updates (ZUPTs) at foot stance detections, zero angular-rate updates (ZARUs) when the user is motionless, and heading corrections using magnetometers. A complementary extended Kalman filter (EKF), throughout its 15-element error state vector, compensates the position, velocity and attitude errors of the INS solution, as well as IMU biases. This methodology is valid for any kind of motion (forward, lateral or backward walk, at different speeds), and does not require an offline calibration for the user gait. The integrated INS+RFID methodology eliminates the typical drift of IMU-alone solutions (approximately 1% of the total traveled distance), resulting in typical positioning errors along the walking path (no matter its length) of approximately 1.5 m.

Análisis de la influencia de la estimulación con vibraciones en la respuesta neuromuscular en competidores de esgrima

La esgrima es un deporte de combate en el que todas las acciones están dirigidas a conseguir el objetivo de la competición, que es el de tocar al contrario sin ser tocado, y para ello los tiradores/as se sirven de todas las herramientas, técnicas, tácticas y de condición física posibles a su alcance. La calidad de las acciones de los esgrimistas en competición dependerá fundamentalmente de dos de los sistemas involucrados en el proceso. Por un lado, la activación del sistema nervioso, y por otro lado la respuesta del sistema muscular. Una de las herramientas utilizadas en los últimos años para estimular el sistema neuromuscular, y que ha reportado en muchas investigaciones resultados positivos, ha sido la plataforma de vibraciones vertical. Por esto, decidimos llevar a cabo un estudio con deportistas de esgrima de competición con un protocolo de exposición aguda a las vibraciones, y medir el efecto producido por esta herramienta sobre el sistema neuromuscular a través del estudio de los cambios experimentados en los tiempos de reacción simple, tiempos de respuesta electiva y tiempos de movimiento, así como los efectos en la eficacia del tocado de esgrima analizados antes y después de recibir el estímulo vibratorio. El estudio se desarrolló con tiradores/as de competición de nivel nacional y pertenecientes al Centro de Tecnificación de la Federación de Esgrima de Castilla y León (n=38; Edad: 22 ±9,08). La muestra estaba compuesta por 12 mujeres y 26 hombres, de categorías, cadetes (13), júnior (12), y absolutos (13). El protocolo elegido fue realizado por cada participante en tres ocasiones, una inicial, otra tras pasar por una carga de estimulación en la plataforma de vibraciones, y una fase final, pasado un tiempo de recuperación de 10 minutos para comprobar el grado de disipación del efecto vibratorio. El estímulo elegido para la estimulación sobre la plataforma de vibraciones fue de una frecuencia de 50 Hz, durante un periodo de 60 segundos y con una amplitud de 4 mm. Los resultados se analizaron en función de las variables dependientes tiempo de reacción, tiempo de respuesta electiva, tiempo de movimiento, y precisión y eficacia. Estos datos se cruzaron con las variables independientes sexo, categoría, nivel deportivo y años de experiencia. El propósito del presente estudio fue el de analizar los efectos producidos por una intervención de estimulación neuromuscular mecánica en fase aguda en un grupo de tiradores/as de esgrima de competición. Los resultados mostraron que la carga de estimulación neuromuscular mecánica (ENM) aplicada en nuestro estudio provocó un discreto efecto en la respuesta neuromuscular de los tiradores participantes en la investigación. Se encontraron efectos significativos provocados por el estímulo vibratorio en las siguientes variables: en el tiempo de reacción simple se registró una mejora del 8,1%, en el tiempo de respuesta electiva a pie parado un 10%, en la precisión a pie parado un 7%, y en la eficacia a pie parado un 18,5%. Igualmente se observaron ligeras diferencias por sexos, encontrando un efecto de mayor tamaño en el grupo femenino. Es necesario resaltar que las características particulares de la muestra parecen haber influido en los resultados encontrados de forma importante. Por último, debemos destacar que el efecto residual producido por la estimulación aplicada en nuestra investigación en algún caso superó los diez minutos, ya que se hallaron efectos positivos de la estimulación neuromuscular mecánica en varios de los registros finales como hemos visto. ABSTRACT Fencing is a combat sport in which all actions are aimed at achieving the objective of the competition, which is that of touching the opponent without being touched and for this the fencers make use of all the tools, techniques, tactics and physical condition possible at their disposal. The quality of the fencers´ actions in competition will depend primarily on two of the systems involved in the process: on the one hand, the activation of the nervous system and, on the other, the response of the muscular system. One of the tools recently used to stimulate the neuromuscular system, and which has produced positive results in many research studies, has been the vertical vibration platform. Therefore, we decided to conduct a study with competition fencers with a protocol of acute exposure to vibration and to measure the effect produced by this tool on the neuromuscular system by means of the study of changes experienced in simple reaction times, the elective response times and movement times, as well as the effects on the efficacy of the fencing touch analyzed before and after receiving the vibratory stimulus. The study was conducted with fencers in national competitions and belonging to the Technification Center of the Fencing Federation of Castilla y León (n = 38), with a mean age of 22 years (SD 9.08). The sample was composed of 12 women and 26 men, by categories cadets (13), juniors (12), and seniors (13). The protocol chosen was performed by each participant on three occasions: an initial one, another after going through a stimulation load on the vibration platform, and a final phase, after a 10 minute recovery time to assess the degree of dissipation of the vibratory effect. The stimulus chosen on the vibration platform was a frequency of 50 Hz, for a period of 60 seconds and an amplitude of 4 mm. The results were analyzed according to the following dependent variables: the reaction time, the response time, the accuracy and the efficiency. This data was crossed with the independent variables: gender, category, sporting level and the years of experience. The purpose of this study was analyze the effects of neuromuscular stimulation intervention in a group of fencing competition shooters. The results showed that the mechanical neuromuscular stimulation (MNS) load applied in our study led to a modest effect on the neuromuscular response of the fencers involved in the research. Significant effects were found caused by the vibratory stimulus on the simple reaction time 8,1%, elective response time 10%, as well as the accuracy 7%, and efficiency 18,5%. We should also point out that slight differences by gender were observed, finding a greater effect in females. It should be emphasized that the specific characteristics of the sample appear to have significantly influenced the results. Finally, we should note that the residual effect produced by the stimulation applied in our research in some cases exceeded ten minutes, given that positive effects of the mechanical neuromuscular stimulation were found in several of the final scores.

El método de José Antonio Corrales y Ramón Vázquez Molezún. Influencias y escenarios arquitectónicos

El siguiente texto plantea un novedoso enfoque sobre el método de trabajo de José Antonio Corrales (1921-2010) y Ramón Vázquez Molezún (1922-1993), enfocado en la primera parte de su obra, la que culminaría con la Casa Huarte en el año 1966. Desarrollaron dos tipologías de proyectos: el pabellón abierto y la arquitectura concentrada. Ambas estrategias combinaban un comprometido diálogo con el lugar con una evidente influencia de diversas referencias arquitectónicas y artísticas de la primera mitad del siglo XX. Corrales y Molezún recibieron una educación clásica, falta de maestros, en una España situada en la autarquía y aislada del exterior, por lo que tuvieron que buscar referencias válidas en el extranjero. La arquitectura de Corrales y Molezún se alimentó de referentes diversos, que abarcan desde la primera Modernidad hasta los revisionistas de los años cincuenta (Team X, Reyner Banham, Ernesto Rogers), pasando por el Nuevo Empirismo nórdico, que representaba un equilibrio entre el racionalismo maquinista de la primera modernidad y las corrientes teóricas rupturistas de italianos y renovadoras de los ingleses. Las distintas corrientes y posicionamientos surgidos en Europa llegaban a España con cuenta gotas, pero resultaban estimulantes para los arquitectos nacionales de posguerra. Corrales y Molezún desarrollaron, desde sus primeros trabajos, un método alimentado por un lado por la influencia de los grandes arquitectos de la Modernidad y por otro por su convencimiento firme de que la arquitectura, además de atender a las necesidades de las personas, debía responder al lugar y dialogar con el paisaje. Este método se basaba en el ejercicio de una práctica teórica, alimentada por la experiencia y comprometida con el oficio. Esta estrategia implicaba un posicionamiento intelectual ante la arquitectura de igual valor que una aproximación teórica. Sus obras son sus manifiestos.

Efecto de una exposición aguda a una estimulación neuromuscular mecánica en el tiempo de respuesta electiva a pie parado en tiradores de esgrima

En este trabajo se aplicó un protocolo de exposición aguda a las vibraciones en competidores de esgrima de nivel nacional, para analizar el efecto producido sobre el sistema neuromuscular en el tiempo de respuesta electiva.