Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity

Formation of the vertebrate axial skeleton requires coordinated Hox gene activity. Hox group 6 genes are involved in the formation of the thoracic area owing to their unique rib-promoting properties. Here we show that the linker region (LR) connecting the homeodomain and the hexapeptide is essential for Hoxb6 rib-promoting activity in mice. The LR-defective Hoxb6 protein was still able to bind a target enhancer together with Pax3, producing a dominant-negative effect, indicating that the LR brings additional regulatory factors to target DNA elements. We also found an unexpected association between Hoxb6 and segmentation in the paraxial mesoderm. In particular, Hoxb6 can disturb somitogenesis and anterior-posterior somite patterning by dysregulation of Lfng expression. Interestingly, this interaction occurred differently in thoracic versus more caudal embryonic areas, indicating functional differences in somitogenesis before and after the trunk-to-tail transition. Our results suggest the requirement of precisely regulated Hoxb6 expression for proper segmentation at tailbud stages.

Avaliação da discrepância maxilar posterior e a sua relação com o padrão de crescimento facial vertical

Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

Posterior circulation cerebrovascular syndromes: diagnosis and management.

One in five strokes affects the posterior circulation. Diagnosing posterior circulation stroke can be challenging, as the vascular anatomy can be variable, and because presenting symptoms are often non-specific and fluctuating. Nevertheless, making the correct diagnosis is important, as these strokes have a high chance of recurrence, can be life threatening, and can lead to equally life-threatening complications. Investigation and management largely follow those for stroke in general, although some specific differences exist. These include the preferred use of MRI for diagnosing posterior fossa lesions, the management of basilar artery thrombosis, which may have a longer time window for recanalisation therapy, and the use of endovascular therapies for secondary prevention, which, so far, have not shown any benefit in the treatment of vertebral or basilar artery stenosis. In this review, we summarise the anatomy, aetiology and presentation of posterior circulation stroke, and discuss current approaches to management.

A method for estimating posterior BAC distributions for persons involved in fatal traffic accidents.

National Highway Traffic Safety Administration, Washington, D.C.

Dissertationes medicae, quarum prior ... sive de membrana allantoide versatur, authore Ludovico de Neufville. Posterior ... seu de clitoride disserit, authore T. Tronchin ...

Mode of access: Internet.

Tentativae Complutensis : tomus posterior in duas divisus partes : in quo ... Ioannis Duns Scoti mens ... elucidatur, comprobatur, defenditur, neque minori studio ac diligentia angelici doctoris doctrina exponitur ... /

Mode of access: Internet.

R.P. Fr. Antonii Castel ... Brevis expositio ad quatuor Petri Lombardi ... sententiarum ... libros ... : tomus quintus, pars posterior.

Parergon de Sacrosancto Oecumenico ac Generali Tridentino Concilio, con portadilla y pag. propias.

Jacobi Pignatelli ... Novissimae consultationes canonicae : praecipuas controversias quae ad fidem eiusquem regulam spectant ... : tomus posterior.

Mode of access: Internet.

De dignitate Cleri tam saecularis quam regularis Dissertationum : pars posterior /

Mode of access: Internet.

Iacobi Gordoni ... Theologia moralis vniuersa octo libris comprehensa ... : tomus prior [-posterior]

Mode of access: Internet.

Turchic[a]e spurciti[a]e et p[er]fidiae suggillatio [et] confutatio : duobus libellis ... conclusa : quorum prior foedissimos mores et turpissima instituta eorum aperit [et] confutat ; posterior Alcoranu[m] turchic[a]e perfidiae instrumemtum ... improbat, confutat, explodit /

Dedicatoria de Iodocus Badius Ascensius a Ioanni Mario Belge.

Theologia polemica : in duas partes divisa, quanum prior Generalia theologiae ... posterior Exhibet materias particulares ... /

Mode of access: Internet.

R.P. Fr. Antonij Castel ... Breuis expositio ad quatuor Petri Lombardi ... sententiarum ... libros ... : tomus quintus, pars posterior ...

Mode of access: Internet.

Theologia naturalis : methodo scientifica pertractata : pars posterior ... /

Mode of access: Internet.

[¿Subsistirá un testamento otorgado con cláusula derogatoria, cuando en otro posterior no se hace mención de ella?] : Discurso leído ante el claustro de la Universidad Central ... /

Tesis de la Universidad Central (Madrid), Faculad de Derecho, leída el 18-06-1867.