536 resultados para Nicolau de Cusa


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Descripción basada en ejemplares del CCPB y de PORBASE.

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At head of title: ... Privy Council. Medical Research Council.

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The dynamic lateral segregation of signaling proteins into microdomains is proposed to facilitate signal transduction, but the constraints on microdomain size, mobility, and diffusion that might realize this function are undefined. Here we interrogate a stochastic spatial model of the plasma membrane to determine how microdomains affect protein dynamics. Taking lipid rafts as representative microdomains, we show that reduced protein mobility in rafts segregates dynamically partitioning proteins, but the equilibrium concentration is largely independent of raft size and mobility. Rafts weakly impede small-scale protein diffusion but more strongly impede long-range protein mobility. The long-range mobility of raft-partitioning and raft-excluded proteins, however, is reduced to a similar extent. Dynamic partitioning into rafts increases specific interprotein collision rates, but to maximize this critical, biologically relevant function, rafts must be small (diameter, 6 to 14 nm) and mobile. Intermolecular collisions can also be favored by the selective capture and exclusion of proteins by rafts, although this mechanism is generally less efficient than simple dynamic partitioning. Generalizing these results, we conclude that microdomains can readily operate as protein concentrators or isolators but there appear to be significant constraints on size and mobility if microdomains are also required to function as reaction chambers that facilitate nanoscale protein-protein interactions. These results may have significant implications for the many signaling cascades that are scaffolded or assembled in plasma membrane microdomains.

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Protein molecular motors, which are natural nano-machines that convert the chemical energy into mechanical work for cellular motion, muscle contraction and cell division, have been integrated in the last decade in primitive nanodevices based on the motility of nano-biological objects in micro- and nano-fabricated structures. However, the motility of microorganisms powered by molecular motors has not been similarly exploited. Moreover, among the proposed devices based on molecular motors, i.e., nanosensors, nano-mechanical devices and nano-imaging devices, biocomputation devices are conspicuously missing. The present contribution discusses, based on the present state of the art nano- and micro-fabrication, the comparative advantages and disadvantages of using nano- and micro-biological objects in future computation devices. (c) 2006 Elsevier B.V. All rights reserved.

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A pesquisa analisou as tendências de formação de professores na perspectiva da educação inclusiva ante as exigências do cotidiano escolar que desde a década de 1990 vem apresentando uma demanda crescente de estudantes com necessidades educacionais especiais nas salas comuns do ensino regular. A inclusão escolar é um processo que depende da combinação de vários fatores, não é responsabilidade apenas do professor. Entretanto, questionamos: Será que os professores estão sendo preparados para pensar nesta perspectiva, de planejar para a diversidade da sala de aula, especialmente na vertente de alunos com deficiência intelectual, de realizar um trabalho em equipe com professores especialistas? A reflexão sobre a formação e a prática de professores na sala de aula inclusiva faz parte do processo de inclusão, ainda em construção. Eis a questão que norteou esta pesquisa, no sentido de revelar impactos das políticas de inclusão escolar nos cursos de formação de professores e na prática docente, revelando conflitos, resistências, contradições, avanços e mecanismos de exclusão implícitos na proposta da inclusão, contribuindo ainda, para a discussão sobre o papel da universidade como locus privilegiado de formação docente. Os resultados da pesquisa apontaram para uma superficialidade na formação de professores na perspectiva da educação inclusiva. A ação investigativa articulou as políticas públicas de formação de professores, as Diretrizes Curriculares Nacionais para as licenciaturas, os dispositivos legais, a sustentação teórica e os instrumentos de investigação para coordenadores, estudantes de Pedagogia e de Letras e professores do Ensino Fundamental em exercício.

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One of the main characteristics of the world that we live in is the access to information and one of the main ways to reach the information is the Internet. Most Internet sites put accessibility problem on a secondary plan. If we try to define this concept (accessibility) we could say that accessibility it’s a way to offer access to information for the people with disabilities. For example blind people can’t navigate on the Internet like usual people. For that reason Internet sites have to put at their disposal ways to make their content known to this people. Accessibility does not refer only at blind people the web accessibility refers to all people who lost their ability to access the Internet sites. The web accessibility includes every disability that stops people with disabilities to access the web sites content like hearing disability, neurological and cognitive. People that have low speed Internet connection or with low performance computers can use the web accessibility.

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Computational Intelligence Methods have been expanding to industrial applications motivated by their ability to solve problems in engineering. Therefore, the embedded systems follow the same idea of using computational intelligence tools embedded on machines. There are several works in the area of embedded systems and intelligent systems. However, there are a few papers that have joined both areas. The aim of this study was to implement an adaptive fuzzy neural hardware with online training embedded on Field Programmable Gate Array – FPGA. The system adaptation can occur during the execution of a given application, aiming online performance improvement. The proposed system architecture is modular, allowing different configurations of fuzzy neural network topologies with online training. The proposed system was applied to: mathematical function interpolation, pattern classification and selfcompensation of industrial sensors. The proposed system achieves satisfactory performance in both tasks. The experiments results shows the advantages and disadvantages of online training in hardware when performed in parallel and sequentially ways. The sequentially training method provides economy in FPGA area, however, increases the complexity of architecture actions. The parallel training method achieves high performance and reduced processing time, the pipeline technique is used to increase the proposed architecture performance. The study development was based on available tools for FPGA circuits.

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In the contemporaneity, due to the implementation of the neoliberal project in which one verifies the withdrawal of the State in regard to the development of social policies, it is observed a new way of responding to the multifaceted expressions of the social issue, which is the emergence and expansion of a supposed "third sector" in society. Thus, the productive restructuring process has led to the deterioration of labor relations, as well as a super exploration of human labor power, also triggering structural unemployment. By being delineated in classist interests, the emergence of the "third sector" brings contradictory aspects to the society, one of these being the very concept of "third sector", more ideological than real. By seeking to answer the expressions of the social issue, demands the intervention of social workers in the institutions that "composes it". This way, arises the interest in researching what are the current conditions and labor relations of the social workers who work in the institutions of the "third sector" in Mossoró-RN. Therefore, this study is constituted by a survey for the conclusion of a Master's degree in Social Service at the Universidade Federal do Rio Grande do Norte. Therefore, it was listed out as general objective to identify and analyze the conditions and labor relations of the social workers entered in the institutions of the "third sector" in Mossoró-RN. And by specific objectives: to map the institutions that are part of the "third sector" in the city of Mossoró, which have social workers on its professional staff, in order to profile the same; and, analyze the main challenges presented to the work of the social worker in these institutions. We used the bibliographic and documental research to enlighten the knowledge of the topic approached and the development of the field research, in which for the analysis of the data obtained, through field research, it was used the quantitative and qualitative approach. The search results confirmed that half of the institutions was identified as philanthropics, and most of them are funded by the federal government and that such organizations develop activities in several areas, particularly health and welfare. Concerning the conditions and labor relations, was highlighted the fact that half of the professionals insert themselves within the institutions by appointment; regarding the salary, 57.1% of employees receive between 3 and 4 minimum wages, which is considered relatively low. Was satisfactory the analysis related to the labor rights, because almost all offer a formal contract, which ensures, in great measure, the effectuation of such rights. Now with regard to the workload, 5 of 6 institutions implemented the Law Nº. 12.317/2010 ensuring 30 hours a week for social workers. However, it were cited many challenges relating the reality of the "third sector" to the conditions and labor relations, among them stands out: the delay of salary and non-salary adjustment; the realization of activities that do not relate to professionals, functions and duties; the development of many activities by a single professional. Two important data are the not incentive to a postgraduate and the charging of the fulfillment of the goals for the professional productivity. Here, it is worth to reflect that, although this study presents elements that provide to identify some aspects of labor relations and conditions of social workers in the "third sector" in Mossoró- RN, as well as some challenges that permeate this space of professional insertion, is meant that there is much to be unveiled, and other studies can later do so in an attempt to a better understanding of the complexity of processes that permeate the "third sector"