National-Theater: Die schlechte Auführung [sic!], 1. Act, darauf folgt Die Versöhnung: Musick: War denn je ein Mensch so frech als wie: Fürst von Haggern: Das ist frech ...

Welsch (Projektbearbeiter): Karikatur auf die sich in kleinlichen Streitigkeiten verzettelnde Frankfurter Nationalversammlung am Beispiel einer Auseinandersetzung zwischen dem Präsidenten Gagern und dem Abgeordneten Rösler

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

The serine and threonine kinase MST1 is the mammalian homolog of Hippo. MST1 is a critical mediator of the migration, adhesion, and survival of T cells; however, these functions of MST1 are independent of signaling by its typical effectors, the kinase LATS and the transcriptional coactivator YAP. The kinase NDR1, a member of the same family of kinases as LATS, functions as a tumor suppressor by preventing T cell lymphomagenesis, which suggests that it may play a role in T cell homeostasis. We generated and characterized mice with a T cell-specific double knockout of Ndr1 and Ndr2 (Ndr DKO). Compared with control mice, Ndr DKO mice exhibited a substantial reduction in the number of naïve T cells in their secondary lymphoid organs. Mature single-positive thymocytes accumulated in the thymus in Ndr DKO mice. We also found that NDRs acted downstream of MST1 to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naïve T cells within popliteal lymph nodes. Together, our findings indicate that the kinases NDR1 and NDR2 function as downstream effectors of MST1 to mediate thymocyte egress and T cell migration.

The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.

Vertebrate odd-skipped related genes (Osr) have an essential function during the formation of the intermediate mesoderm (IM) and the kidney structures derived from it. Here, we show that these genes are also crucial for limb bud formation in the adjacent lateral plate mesoderm (LPM). Reduction of zebrafish Osr function impairs fin development by the failure of tbx5a maintenance in the developing pectoral fin bud. Osr morphant embryos show reduced wnt2b expression, and increasing Wnt signaling in Osr morphant embryos partially rescues tbx5a expression. Thus, Osr genes control limb bud development in a non-cell-autonomous manner, probably through the activation of Wnt2b. Finally, we demonstrate that Osr genes are downstream targets of retinoic acid (RA) signaling. Therefore, Osr genes act as a relay within the genetic cascade of fin bud formation: by controlling the expression of the signaling molecule Wnt2ba in the IM they play an essential function transmitting the RA signaling originated in the somites to the LPM.

Zuhause [Rezension] : (Drama in einem Act von Georg Hirschfeld)

Maximilian Barber

Redlining, the Community Reinvestment Act, and Private Mortgage Insurance

This paper examines whether neighborhood racial or income composition influences a lender's treatment of mortgage applications. Recent studies have found little evidence of differential treatment based on either the racial or income composition of the neighborhood, once the specification accounts for neighborhood risk factors. This paper suggests that lenders may favor applicants from CRA-protected neighborhoods if they obtain Private Mortgage Insurance (PMI) and that this behavior may mask lender redlining of low income and minority neighborhoods. For loan applicants who are not covered by PMI, this paper finds strong evidence that applications for units in low-income neighborhoods are less likely to be approved, and some evidence that applications for units in minority neighborhoods are less likey to be approved, regardless of the race of the applicant. This pattern is not visible in earlier studies because lenders appear to treat applications from these neighborhoods more favorably when the applicant obtains PMI.

Herr Tewele vom Carltheater in Wien als "Wasserstein" [Illustration] : I. Act

Scan von Monochrom-Mikroform

Herr Tewele vom Carltheater in Wien als "Wasserstein" [Illustration] : III. Act

Scan von Monochrom-Mikroform

"Contra Rüppell!" Ein Act der Intoleranz von einem Manne der Wissenschaft. Zur Abwehr

von Leopold Stein

Mus Hs Opern 275 (1) - Der Tausch : Operette in I Act

mit Musick von Fd. Herold

Die Nürnberger Puppe : komische Oper in 1 Act

Musik von A. Adam. [Text] von Leuven und A. Beauplan. Dt. von Ernst Pasqué

Fragm. lat. I 5 - Biblia (Teile aus Act, Iac, I-II Pt)

Trägerband: Inc. qu. 716; Inc. oct. 427; Ms. Praed. 92; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Meistersinger (I. Act.)

Signatur des Originals: S 36/F07562

Meistersinger (I. Act.)

Signatur des Originals: S 36/F07564