913 resultados para Monarquia Dual


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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Based on the cohomology theory of groups, Andrade and Fanti defined in [1] an algebraic invariant, denoted by E(G,S, M), where G is a group, S is a family of subgroups of G with infinite index and M is a Z2G-module. In this work, by using the homology theory of groups instead of cohomology theory, we define an invariant ``dual'' to E(G, S, M), which we denote by E*(G, S, M). The purpose of this paper is, through the invariant E*(G, S, M), to obtain some results and applications in the theory of duality groups and group pairs, similar to those shown in Andrade and Fanti [2], and thus, providing an alternative way to get applications and properties of this theory.

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This article aims to analyze the significant social and political aspects of the transition from the Parliamentary Constitutional Monarchy to Federal and Presidential Republic, according to the literary work of the writer from Rio de Janeiro Joaquim Maria Machado de Assis (1839-1908). Some of these aspects appeared in Machadian chronicles entitled Balas de Estalo, published in the daily newspaper Gazeta News between 1883 and 1887. These chronicles were signed by Lelio, one of the nicknames of Machado de Assis.

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This paper aims to present some characteristics of Hispania in Late Antiquity and Early Middle Ages (4th-8th centuries). Search through a brief analysis of the relationship between Christianity and the Catholic Monarchy stood raise some issues and questions. We understand that Christianity has played and plays a significant role in the historical development of the Iberian countries. But in its installation and attempt to consolidation as hegemonic religion in the peninsula, faced several challenges. His alliance with the monarchy stood represented one of the ways to make stronger its dominance. In turn, the Monarchy, preserving its characteristic elective associated strongly with Christianity, giving him a theocratic character trying to raise the sovereign above the fray aristocratic, without much success. Thus, our text points to some of the paths followed by these two elements, Christianity and Monarchy at the time of the Kingdom of Toledo, proposing more reflections and ways that effectively covering them. We hope to have achieved it.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Mirabegron is the first β3-adrenoceptor (AR) agonist approved for treatment of overactive bladder syndrome (OAB). This study aimed to investigate the effects of β3-adrenoceptor (AR) agonist mirabegron in mouse urethra. The possibility that mirabegron exerts α1-AR antagonism was also tested in rat smooth muscle preparations presenting α1A- (vas deferens and prostate), α1D- (aorta) and α1B-AR (spleen). Functional assays were carried out in mouse and rat isolated tissues. Competition assays for the specific binding of [(3) H]Prazosin to membrane preparations of HEK 293 cells expressing each of the human α1-ARs, as well as β-AR mRNA expression and cyclic AMP measurements in mouse urethra were performed. Mirabegron produced concentration-dependent urethral relaxations that were right shifted by the selective β3-AR antagonist L 748,337, but unaffected by β1- and β2-AR antagonists (atenolol and ICI 118,551, respectively). Mirabegron-induced relaxations were enhanced by the phosphodiesterase-4 inhibitor rolipram, and this agonist stimulated cAMP synthesis. Mirabegron also produced rightward shifts in urethral contractions induced by the α1-AR agonist phenylephrine. Schild regression analysis revealed that mirabegron behaves as a competitive antagonist of α1-AR in urethra, vas deferens and prostate (α1A-AR, pA2  ≅ 5.6) and aorta (α1D-AR, pA2  ≅ 5.4), but not in spleen (α1B-AR). The affinities estimated for mirabegron in functional assays were consistent with those estimated in radioligand binding with human recombinant α1A- and α1D-ARs (pKi ≅ 6.0). The effects of mirabegron in urethral smooth muscle are the result of β3-AR agonism together with α1A / α1D-AR antagonism.

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Flavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient (high levels), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced turn-off activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Este artigo traz os resultados obtidos através do estudo e da aplicação do Método Primal-Dual Previsor-Corretor de Pontos Interiores para Problema de Programação Quadr´atica convexa a um Problema de Despacho Econômico (PDE) e a um Problema Multiobjetivo de Despacho Econômico e Ambiental (DEA). O primeiro problema busca determinar a solução ótima aproximada, minimizando os custos dos combustíveis empregados na geração termoelétrica de energia e satisfazendo as restrições operacionais. Já o segundo é solucionado através do Método da Soma Ponderada, que apresenta um balanceamento entre o problema de otimização dos custos e o problema de emissão de poluentes. Ao final do artigo, um algoritmo para cada problema é proposto e implementado computacionalmente utilizando o software Borland C++ Builder 6.0. Os testes foram realizados utilizando um PDE de 13 geradores e um DEA de 06 geradores e os resultados obtidos demonstram a eficiˆencia dos m´etodos quando comparados a outros encontrados na literatura.

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This paper proposes a technique for solving the multiobjective environmental/economic dispatch problem using the weighted sum and ε-constraint strategies, which transform the problem into a set of single-objective problems. In the first strategy, the objective function is a weighted sum of the environmental and economic objective functions. The second strategy considers one of the objective functions: in this case, the environmental function, as a problem constraint, bounded above by a constant. A specific predictor-corrector primal-dual interior point method which uses the modified log barrier is proposed for solving the set of single-objective problems generated by such strategies. The purpose of the modified barrier approach is to solve the problem with relaxation of its original feasible region, enabling the method to be initialized with unfeasible points. The tests involving the proposed solution technique indicate i) the efficiency of the proposed method with respect to the initialization with unfeasible points, and ii) its ability to find a set of efficient solutions for the multiobjective environmental/economic dispatch problem.