New Generation Antidepressants in Painful Diabetic Neuropathy

The incidence of diabetic neuropathy increases with the duration of diabetes and the degree of hyperglycaemia. Pain is one of the most common and incapacitating symptoms of diabetic neuropathy and its pharmacological control is complex. The effectiveness of antidepressive agents has been described in different types of neuropathic pain, but their effectiveness, when used as analgesics in painful diabetic neuropathy, still remains controversial. Objective: To review the possible role of new-generation antidepressive agents in the treatment of pain in diabetic peripheral neuropathy. This work has thus consisted of a meta-analysis for determining which antidepressive agent had the best analgesic potential in managing pain in patients suffering from painful diabetic neuropathy. Methods: This search covered the Cochrane, MEDLINE, EMBASE and LILACS databases, between January 2000 and August 2007. The following information was obtained from each article: criteria for diagnosing diabetic neuropathy, patients' age average, antidepressant drug received and dose, sample size, duration of the disease and treatment follow-up, outcome measurement, evaluation of pain and rescue medication. Results: A combined RR: 1.67 (95% CI 1.38 - 2.02) was obtained; this result indicated that the antidepressive agent duloxetine, was effective for controlling pain in diabetic neuropathy. The corresponding NNT for Duloxetine was established, according to our interests; NNT = 6 (95% CI 5- 8) for achieving greater than 50% analgesia in patients suffering from painful diabetic neuropathy. Discussion: Antidepressive agents are frequently employed in the specific case of diabetic neuropathy; their analgesic benefit has been demonstrated.

Methodology for measuring the impact of mobile technology change from 2nd to 3th generation percerved by users of smes in Barranquilla

This article presents the results of a research project undertaken to obtain a Masters inBusiness Administration from the Business School at the Universidad del Norte, whosepurpose was to identify and test a methodology to measure the impact exerted by thechange from 2nd to 3rd generation mobile tech, based on the perception of users belongingto Barranquilla SME, motivated by the influence of technological changes in behavior andthe knowledge creation among society members, and the importance it has taken to thesurvival of organizations the adoption of applications for process automation, web-basedapplications, voice, data and video that allow the development of competitive advantages,based on information and creativity for new and better products or services.

Modernisme : segona generació = Modernismo : segunda generación = Modernisme : the second generation = Le Modernisme : seconde génération.

Guía para la visita de las salas quince y diecisiete del Museo de Arte Moderno de Cataluña. Estas salas tratan contenidos sobre la segunda generación del Modernismo. Mediante un mapa, esta guía orienta al visitante por los distintos espacios de las salas.

Noucentisme : la generació del 1917 = Noucentisme : la generación de 1917 = Noucentisme : the generation of 1917 = Le Noucentisme : la génération de 1917.

Guía para la visita de la sala veinte del Museo de Arte Moderno de Cataluña. Esta sala trata contenidos sobre el movimento artístico catalán Noucentisme, en concreto, la llamada Generación de 1917. Mediante un mapa, esta guía orienta al visitante por los distintos espacios de la sala.

Text generation : writing 11 to 14. Book 1.

Recurso para ayudar a los estudiantes de primero de secundaria a mejorar el nivel en la escritura. Cubre todas las etapas del proceso de escritura y los objetivos señalados para la enseñanza del inglés e incluye, entre otros, la creación de personajes, la escritura de relatos cortos, la escritura de reseñas y el lenguaje del marketing.

Text generation : writing 11 to 14. Book 2.

Recurso para ayudar a los estudiantes de segundo de secundaria a aumentar el nivel en la escritura. Cubre todas las etapas del proceso de escritura y los objetivos señalados para la enseñanza del inglés e incluye, entre otros, el lenguaje figurado, la forma poética, narración de cuentos, información, descripción y análisis, la retórica persuasiva y la lógica persuasiva.

Text generation : writing 11 to 14. Book 3.

Recurso para ayudar a los estudiantes de secundaria a aumentar el nivel en la escritura. Cubre todas las etapas del proceso de escritura y los objetivos señalados para la enseñanza del inglés e incluye, entre otros, la narrativa, formas poéticas, literatura de viajes, argumento persuasivo, análisis literario y tipos de texto y parodia.

Are discourse comprehension and cognitive processes influenced by the type of language language (English and Spanish)? A cross-language study based on elaborative inferences generation

Resumen basado en el de la publicación

The effects of question-generation training on metacognitive knowledge, self regulation and learning approaches in Science

Resumen tomado de la publicaci??n

Automatic generation of active coordinates for quantum dynamics calculations: application to the dynamics of benzene photochemistry

A new practical method to generate a subspace of active coordinates for quantum dynamics calculations is presented. These reduced coordinates are obtained as the normal modes of an analytical quadratic representation of the energy difference between excited and ground states within the complete active space self-consistent field method. At the Franck-Condon point, the largest negative eigenvalues of this Hessian correspond to the photoactive modes: those that reduce the energy difference and lead to the conical intersection; eigenvalues close to 0 correspond to bath modes, while modes with large positive eigenvalues are photoinactive vibrations, which increase the energy difference. The efficacy of quantum dynamics run in the subspace of the photoactive modes is illustrated with the photochemistry of benzene, where theoretical simulations are designed to assist optimal control experiments

Le musee local de la nouvelle generation au Portugal, un pas en avant dans la gestion communautaire qualitative : essai d'interprétation épistémologique

Le musée local, au Portugal, tel qu’il apparaît dans la perspective de la révolution socio-cultureile de 74, puis projeté à l’avant-scène de la muséologie portugaise renaissante, lors du IIe Atelier international de Nouvelle muséologie (Lisbonne/Seixal/Monte Redondo — Musées locaux/Nouvelle musólogie, novembre 85), se perpétue jusqu’à nos jours, tout au moins dans le discours de ses promoteurs, préoccupé par le rapport aux pouvoirs et aux populations. Fortement enraciné dans la structure municipale et associative, utilisé à ses débuts, à des degrés divers, comme un outil de militance communautaire, le musée local présente un modèle muséographique de type ethnographique diffusé à travers le pays. Celui-ci est fondé sur la participation de donateurs d’objets utiles de la vie courante, mis à contribution dans le programme, de même que sur l’apport des savoir-faire populaires et artisanaux, évitant de tomber dans le folklorisme par une réflexion alimentée par les universitaires. Ce mouvement naissant correspond à la mode de l’écomusée dont il épouse certains contours, tout en demeurant enraciné dans la tradition ethnographique du pays.

On the generation mechanisms of short-scale unbalanced modes in rotating two-layer flows with vertical shear

We report on the results of a laboratory investigation using a rotating two-layer annulus experiment, which exhibits both large-scale vortical modes and short-scale divergent modes. A sophisticated visualization method allows us to observe the flow at very high spatial and temporal resolution. The balanced long-wavelength modes appear only when the Froude number is supercritical (i.e. $F\,{>}\,F_\mathrm{critical}\,{\equiv}\, \upi^2/2$), and are therefore consistent with generation by a baroclinic instability. The unbalanced short-wavelength modes appear locally in every single baroclinically unstable flow, providing perhaps the first direct experimental evidence that all evolving vortical flows will tend to emit freely propagating inertia–gravity waves. The short-wavelength modes also appear in certain baroclinically stable flows. We infer the generation mechanisms of the short-scale waves, both for the baro-clinically unstable case in which they co-exist with a large-scale wave, and for the baroclinically stable case in which they exist alone. The two possible mechanisms considered are spontaneous adjustment of the large-scale flow, and Kelvin–Helmholtz shear instability. Short modes in the baroclinically stable regime are generated only when the Richardson number is subcritical (i.e. $\hbox{\it Ri}\,{<}\,\hbox{\it Ri}_\mathrm{critical}\,{\equiv}\, 1$), and are therefore consistent with generation by a Kelvin–Helmholtz instability. We calculate five indicators of short-wave generation in the baroclinically unstable regime, using data from a quasi-geostrophic numerical model of the annulus. There is excellent agreement between the spatial locations of short-wave emission observed in the laboratory, and regions in which the model Lighthill/Ford inertia–gravity wave source term is large. We infer that the short waves in the baroclinically unstable fluid are freely propagating inertia–gravity waves generated by spontaneous adjustment of the large-scale flow.