bepress Launches Beta of Expert Gallery to Promote Research Expertise

We at bepress are excited to announce the beta launch of the Expert Gallery, a new product for institutions eager to highlight the rich expertise of their faculty. The Expert Gallery facilitates the valuable work of connecting an institution’s researchers with opportunities that might otherwise be missed. Groups such as Marketing and Communications and the Office of Research can use the product to better land funding opportunities, speaking engagements, and professional collaborations for top faculty members. The Expert Gallery is designed to let stakeholders within and outside of the institution find researchers by interest, skill set, and research emphasis: simple searching and browsing, along with the flexibility to create and display custom galleries, helps facilitate targeted discovery for experts on campus. A built-in, rich toolset lets institutions organize, manage, and connect their researchers to the right opportunities and interested parties outside the institution. While most expert galleries contain just biographical information and a bibliography, integration of the bepress Expert Gallery with SelectedWorks profiles lets researchers prove their expertise with a full picture of their scholarly research, including published and unpublished works, datasets, teaching materials, and media appearances. Launching the Expert Gallery as a new product reflects an important expansion of bepress’s mission. For years we’ve helped libraries reclaim their central role through providing services across campus. We’ve especially focused on supporting the library in its important efforts to promote the institution through the scholarship it produces. With the Expert Gallery, the library can meet its campus’s needs to go beyond demonstrating the value of its scholarship. Now the library can offer a way to promote the institution through the rich skills of the people who make it unique. We plan to continue on this path of helping institutions maximize the impact of people as well as their people’s scholarship. In early 2017 we will launch a suite of services that includes SelectedWorks, the Expert Gallery, and a set of faculty reporting and analytics tools.

CHARACTERIZATION OF TOBACCO MOSAIC VIRUS DIRECTED REPROGRAMMING OF PHLOEM GENE EXPRESSION TO PROMOTE VIRAL PHLOEM LOADING AND SYSTMEIC MOVEMENT

Vascular phloem loading has long been recognized as an essential step in the establishment of a systemic virus infection. Yet little is known about this process and the mechanisms that control it. In this study, an interaction between the replication protein of Tobacco mosaic virus (TMV) and phloem specific auxin/indole acetic acid (Aux/IAA) transcriptional regulators was found to modulate virus phloem loading. Promoter expression studies show TMV 126/183 kDa interacting Aux/IAAs predominantly express and accumulate within the nuclei of phloem companion cells (CC). Furthermore, CC Aux/IAA nuclear localization is disrupted upon infection with an interacting virus but not during infection with a non-interacting virus. In situ analysis of virus spread shows the inability of TMV variants to disrupt Aux/IAA CC nuclear localization correlates with a reduced ability to load into the vascular tissue. Subsequent systemic movement assays also demonstrate that a virus capable of disrupting Aux/IAA localization is significantly more competitive at systemic movement than a non-interacting virus. Similarly, CC expression and over-accumulation of a degradation-resistant-interacting Aux/IAA protein was found to selectively inhibit TMV accumulation and phloem loading. Transcriptional expression studies demonstrate a role for interacting Aux/IAA proteins in the regulation of salicylic acid and jasmonic acid dependent host defense responses as well as virus specific movement factors including pectin methylesterase that are involved in regulating plasmodesmata size exclusion limits and promoting virus cell-to-cell movement. Further characterization of the phloem environment was done using two phloem specific promoters (pSUC2 and pSULTR2;2) to generate epitope-tagged polysomal-RNA complexes. Immuno-purification using the epitope tag allowed us to obtain mRNAs bound to polysomes (the translatome) specifically in phloem tissue. We found the phloem translatome is uniquely altered during TMV infection with 90% and 88% of genes down regulated in the pSUC2 and pSULTR2;2 phloem translatomes, compared to 31% of genes down regulated in the whole plant p35S translatome. Transcripts down regulated in phloem include genes involved in callose deposition at plasmodesmata, host defense responses, and RNA silencing. Combined, these findings indicate TMV reprograms gene expression within the vascular phloem as a means to enhance phloem loading and systemic spread.

Paradigms that guide the models of attention to the health in Brazil: an analytic essay

SILVA, Flávio César Bezerra da ; COSTA, Francisca Marta de Lima; ANDRADE, Hamilton Leandro Pinto de; FREIRE, Lúcia de Fátima; MACIEL, Patrícia Suerda de Oliveira; ENDERS, Bertha Cruz ; MENEZES, Rejane Maria Paiva de. Paradigms that guide the models of attention to the health in Brazil: an analytic essay. Revista de Enfermagem UFPE On Line., Recife, v.3,n.4, p.460-65. out/dez. 2009. Disponível em < http://www.ufpe.br/revistaenfermagem/index.php/revista/search/results >.

Neurofilaments and NFL-TBS.40-63 peptide penetrate oligodendrocytes through clathrin-dependent endocytosis to promote their growth and survival in vitro.

International audience

A systems approach to cardiovascular health and disease with a focus on aortic wave dynamics

Cardiovascular diseases (CVDs) have reached an epidemic proportion in the US and worldwide with serious consequences in terms of human suffering and economic impact. More than one third of American adults are suffering from CVDs. The total direct and indirect costs of CVDs are more than $500 billion per year. Therefore, there is an urgent need to develop noninvasive diagnostics methods, to design minimally invasive assist devices, and to develop economical and easy-to-use monitoring systems for cardiovascular diseases. In order to achieve these goals, it is necessary to gain a better understanding of the subsystems that constitute the cardiovascular system. The aorta is one of these subsystems whose role in cardiovascular functioning has been underestimated. Traditionally, the aorta and its branches have been viewed as resistive conduits connected to an active pump (left ventricle of the heart). However, this perception fails to explain many observed physiological results. My goal in this thesis is to demonstrate the subtle but important role of the aorta as a system, with focus on the wave dynamics in the aorta.

The operation of a healthy heart is based on an optimized balance between its pumping characteristics and the hemodynamics of the aorta and vascular branches. The delicate balance between the aorta and heart can be impaired due to aging, smoking, or disease. The heart generates pulsatile flow that produces pressure and flow waves as it enters into the compliant aorta. These aortic waves propagate and reflect from reflection sites (bifurcations and tapering). They can act constructively and assist the blood circulation. However, they may act destructively, promoting diseases or initiating sudden cardiac death. These waves also carry information about the diseases of the heart, vascular disease, and coupling of heart and aorta. In order to elucidate the role of the aorta as a dynamic system, the interplay between the dominant wave dynamic parameters is investigated in this study. These parameters are heart rate, aortic compliance (wave speed), and locations of reflection sites. Both computational and experimental approaches have been used in this research. In some cases, the results are further explained using theoretical models.

The main findings of this study are as follows: (i) developing a physiologically realistic outflow boundary condition for blood flow modeling in a compliant vasculature; (ii) demonstrating that pulse pressure as a single index cannot predict the true level of pulsatile workload on the left ventricle; (iii) proving that there is an optimum heart rate in which the pulsatile workload of the heart is minimized and that the optimum heart rate shifts to a higher value as aortic rigidity increases; (iv) introducing a simple bio-inspired device for correction and optimization of aortic wave reflection that reduces the workload on the heart; (v) deriving a non-dimensional number that can predict the optimum wave dynamic state in a mammalian cardiovascular system; (vi) demonstrating that waves can create a pumping effect in the aorta; (vii) introducing a system parameter and a new medical index, Intrinsic Frequency, that can be used for noninvasive diagnosis of heart and vascular diseases; and (viii) proposing a new medical hypothesis for sudden cardiac death in young athletes.

Impact of dental caries on quality of life of adolescents according to access to oral health services: a cross sectional study

Aim: This study presents the prevalence of dental caries and its relation to the quality of life of adolescents according to the access to dental health services. Methods: Two hundred and fifty-six adolescents between 15 and 19 years of age participated in the study; they were all enrolled in public schools in a countryside municipality of the São Paulo State. Data related to dental caries were evaluated by the DMFT Index, and OHIP-14 was used for evaluating the quality of life. Mann Whitney and Spearmann correlation tests were also used (p<0.05). Results: A DMFT of 3.09 (±3.30) was found with a higher prevalence among the adolescents who used public dental services (3.43±3.34) compared with those who used private services (2.94±3.28). A statistically significant relationship between the decay component of DMFT with physical pain (0.020), physical disability (0.002) and quality of life (0.017) was verified. Conclusions: A low prevalence of dental caries was observed, and it was higher in adolescents who used public oral health services rather than private ones, evidencing the low influence of oral health on the quality of life of the participants.

Prevalence of chronic diseases in private healthcare sector of South Africa: A threat to public health

Purpose: To evaluate the prevalence of patients suffering from registered chronic disease list (CDL) conditions in a section of the South African private health sector from 2008 - 2012. Methods: This study was a retrospective analysis of the medicine claims database of a nationally (South African) representative Pharmacy Benefit Management (PBM) company data between 2008 and 2012. Statistical analysis was used to analyse the data. Descriptive analysis was performed to calculate the prevalence of CDL conditions for the entire population, and stratified by age and gender. However, MIXED linear modelling was used to determine changes in the average number of CDL conditions per patient, adjusted for age and gender from 2008 - 2012. Results: An increase of 0.20 in chronic diseases was observed from 2008 - 2012 in patients having any CDL condition, with an average of 1.57 (1.57 - 1.58, 95 % CI) co-morbid CDL conditions in 2008 and 1.77 (1.77 - 1.78, 95 % CI) in 2012. This increase in average number of CDL conditions per patient between 2008 and 2012 was statistically significant (p < 0.05), but with no large practical significance (d < 0.8). Conclusion: Prevalence of patients with CDL conditions along with risk of co-morbidity has been increasing with time in the private health sector of South Africa. Risk of increased co-morbidity with age and among different genders was prevalent.

Repeated Readings to Promote Fluency for Students with Intellectual Disabilities

Reading fluency is a skill that’s difficult for many students to acquire. However, research suggests that consistently implementing the Repeated Reading intervention can help students increase fluency and comprehension. The effect of this strategy when used to promote reading fluency in secondary students with severe intellectual disabilities has yet to be investigated. My research will examine the effect of the Repeated Reading intervention on the fluency level of students with intellectual disabilities in a public high school.

Strategies to Promote Research and Logical Reasoning in the Teaching of Mathematics in the Schools

The purpose of this paper is to raise a debate on the urgent need for teachers to generate innovative situations in the teaching-learning process, in the field of Mathematics, as a way for students to develop logical reasoning and research skills applicable to everyday situations. It includes some statistical data and possible reasons for the poor performance and dissatisfaction of students towards Mathematics. Since teachers are called to offer meaningful and functional learning experiences to students, in order to promote the pleasure of learning, teacher training should include experiences that can be put into practice by teachers in the education centers. This paper includes a work proposal for Mathematics Teaching to generate discussion, curiosity and logical reasoning in students, together with the Mathematical problem solving study.

Design of mobility infrastructures to promote sustainability and accessibility of urban areas

This doctoral dissertation represents a cluster of research activities carried out at the DICAM Department of the University of Bologna during a three-year Ph.D. course. The goal of this research is to show how the development of an interconnected infrastructure network, aimed at promoting accessibility and sustainability of places, is fundamental in a framework of deep urban regeneration. Sustainable urban mobility plays an important role in improving the quality of life of citizens. From an environmental point of view, a sustainable mobility system means reducing fuel discharges and energy waste and, in general, aims to promote low carbon emissions. At the same time, a socially and economically sustainable mobility system should be accessible to everybody and create more job opportunities through better connectivity and mobility. Environmentally friendly means of transport such as non-motorized transport, electric vehicles, and hybrid vehicles play an important role in achieving sustainability but require a planned approach at the local policy level. The aim of this study is to demonstrate that, through a targeted reconnection of road and cycle-pedestrian routes, the quality of life of an urban area subject to degradation can be significantly improved just by increasing its accessibility and sustainability. Starting from a detailed study of the European policies and from the comparison with real similar cases, the case study of the Canal Port of Rimini (Italy) has been analysed within the European project FRAMESPORT. The analysis allowed the elaboration of a multicriterial methodology to get to the definition of a project proposal and of a priority scale of interventions. The applied methodology is a valuable tool that may be used in the future in similar urban contexts. Finally, the whole project was represented by using virtual reality to visually show the difference between the before and after the regeneration intervention.

Contaminants of emerging concern in drinking water: assessment of the effectiveness of removal by drinking water treatments and possible risks to human health

Contaminants of emerging concern are increasingly detected in the water cycle, with endocrine-disrupting chemicals (EDCs) receiving attention due to their potential to cause adverse health effects even at low concentrations. Although the EU has recently introduced some EDCs into drinking water legislation, most drinking water treatment plants (DWTPs) are not designed to remove EDCs, making their detection and removal in DWTPs an important challenge. The aim of this doctoral project was to investigate hormones and phenolic compounds as suspected EDCs in drinking waters across the Romagna area (Italy). The main objectives were to assess the occurrence of considered contaminants in source and drinking water from three DWTPs, characterize the effectiveness of removal by different water treatment processes, and evaluate the potential biological impact on drinking water and human health. Specifically, a complementary approach of target chemical analysis and effect-based methods was adopted to explore drinking water quality, treatment efficacy, and biological potential. This study found that nonylphenol (NP) was prevalent in all samples, followed by BPA. Sporadic contamination of hormones was found only in source waters. Although the measured EDC concentrations in drinking water did not exceed threshold guideline values, the potential role of DWTPs as an additional source of EDC contamination should be considered. Significant increases in BPA and NP levels were observed during water treatment steps, which were also reflected in estrogenic and mutagenic responses in water samples after the ultrafiltration. This highlights the need to monitor water quality during various treatment processes to improve the efficiency of DWTPs. Biological assessments on finished water did not reveal any bioactivity, except for few treated water samples that exhibited estrogenic responses. Overall, the data emphasize the high quality of produced drinking water and the value of applying integrated chemical analysis and in vitro bioassays for water quality assessment.

Estudo da distribuição da pressão plantar e do equilibrio corporal em corredores de longa distancia

Universidade Estadual de Campinas . Faculdade de Educação Física

Avaliação do consumo alimentar e da ingestão de nutrientes na prática clínica

A avaliação do consumo alimentar na prática clínica é realizada com a finalidade de fornecer subsídios para o desenvolvimento e a implantação de planos nutricionais. Fatores como condições do estado geral do indivíduo/paciente, evolução da condição clínica e os motivos pelos quais o indivíduo necessita de orientação nutricional direcionam a escolha do método de avaliação do consumo alimentar. O método escolhido deve fornecer informações que permitam ao profissional orientar uma alimentação que vise promover a saúde, prevenir outras intercorrências e adequar o estado nutricional do paciente. Apesar de a literatura nacional disponibilizar informações abrangentes sobre métodos e técnicas para estimativa do consumo alimentar, o ambiente de atuação profissional ainda está permeado de dúvidas a respeito dos métodos mais adequados para essa avaliação na prática diária. O presente artigo se propôs a apresentar uma análise crítica, no contexto da aplicabilidade clínica, dos métodos disponíveis de inquéritos alimentares e suas características.

Promoção da Saúde, Sustentabilidade e Agroecologia: uma discussão intersetorial

Analisando a abordagem conceitual dos ideários de Agroecologia e da Promoção da Saúde, percebe-se a aproximação desses campos científicos e práticos a partir de suas diretrizes comuns de fomentar a democracia, promover a cidadania, o empowerment, a autonomia e a participação comunitária dos atores sociais, resgatar saberes e práticas tradicionais e populares, além de promover saúde, qualidade de vida e sustentabilidade nos níveis ambiental, social e econômico. Entretanto, apesar de suas interfaces comuns, esses dois campos não têm dialogado. A Agroecologia e sua potencial ação de promoção de saúde no meio rural não têm sido discutidas na Saúde Pública e na Promoção da Saúde; por sua vez, tais áreas tampouco têm produzido conhecimentos que possam contribuir para o fortalecimento da Agroecologia enquanto estratégia de promoção da saúde. Esse artigo pretende ressaltar a relação entre esses dois campos de estudos, explorando-os conceitualmente. Além disso, o artigo sinaliza a Agroecologia como uma estratégia intersetorial de promoção da saúde, de sustentabilidade e de segurança alimentar e nutricional.

Saúde e adolescentes: possibilidades de violência simbólica

Este artigo se propõe a analisar o tipo de relação que as Unidades de Saúde estabelecem com os adolescentes no município de Fortaleza, CE, na perspectiva da violência simbólica de Pierre Bourdieu. Para tanto, foram organizados seis grupos focais constituídos de profissionais das Unidades Básicas de Saúde da Família. O número de participantes variou de 10 a 15 pessoas. Os critérios de escolha das Unidades foram: aquelas que já realizaram algum projeto de promoção à saúde ou prevenção de doenças com adolescentes; que possuem profissionais que são reconhecidos por desenvolverem atendimento junto aos adolescentes. As falas do grupo foram anotadas e transcritas por um observador independente. O material coletado foi analisado de acordo com os critérios clássicos da análise de conteúdo. Os resultados mostraram que há uma descrença na implantação de políticas públicas para a saúde na adolescência e que a sustentabilidade de programas e projetos fica fragilizada pela ausência dessa estrutura de apoio às ações no cuidado aos adolescentes