Synthesis and Coordination Chemistry of a New N-4-Polydentate Class of Pyridyl-Functionalized Scorpionate Ligands: Complexes of Fe-II, Zn-II, V-IV, Pd-II and Use for Heterobimetallic Systems

The new potentially N-4-multidentate pyridyl-functionalized scorpionates 4-((tris-2,2,2-(pyrazol-1-ypethoxy)methyl)pyridine (TpmPy, (1)) and 4-((tris-2,2,2-(3-phenylpyrazol-1-yl)ethoxy)methyl)pyridine (TpmPy(Ph), (2)) have been synthesized and their coordination behavior toward Fe-II, Ni-II, Zn-II, Cu-II, Pd-II, and V-III centers has been studied. Reaction of (1) with Fe(BF4)(2)center dot 6H(2)O yields [Fe(TpmPy)(2)](BF4)(2) (3), that, in the solid state, shows the sandwich structure with trihapto ligand coordination via the pyrazolyl arms, and is completely low spin (LS) until 400 K. Reactions of 2 equiv of (1) or (2) with Zn-II or Ni-II chlorides give the corresponding metal complexes with general formula [MCl2(TpmPy*)(2)] (M = Zn, Ni; TpmPy* = TpmPy, TpmPy(Ph)) (4-7) where the ligand is able to coordinate through either the pyrazolyl rings (in case of [Ni(TpmPy)(2)Cl-2 (5)) or the pyridyl-side (for [ZnCl2(TpmPy)(2)] (4), [ZnCl2(TpmPy(Ph))(2)] (6) and [NiCl2(TpmPy(Ph))(2)] (7)). The reaction of (1) with VCl3 gives [VOCl2(TpmPy)] (8) that shows the N-3-pyrazolyl coordination-mode. Moreover, (1) and react with cis-[PdCl2(CH3CN)(2)] to give the disubstituted complexes [PdCl2(TprnPy)(2)] (9) and [PdCl2(TpmPy(Ph))(2)] (10), respectively, bearing the scorpionate coordinated via the pyridyl group. Compounds (9) and (10) react with Fe(BF4)(2) to give the heterobimetallic Pd/Fe systems [PdCl2(mu-TpmPy)(2)-Fe](BF4)(2) (11) and [PdCl2(mu-TpmPy(Ph))(2)Fe-2(H2O)(6)]BF4)(4) (13), respectively. Compound (11) can also be formed from reaction of (3) with cis-[PdCl2(CH3CN)(2)], while reaction of (3) with Cu(NO3)(2).2.5H(2)O generates [Fe(mu-TpmPy)(2)-Cu(NO3)(2)](BF4)(2) (12), confirming the multidentate ability of the new chelating ligands. The X-ray diffraction analyses of compounds (1), (3), (4), (5), and (9) are also reported.

Ajustes posturais para o alcance funcional dos membros superiores - migra����o do centro de press��o na posi����o de sentado

Objetivos: Pretende-se verificar as modifica����es neuromotoras ap��s uma interven����o baseada no conceito de Bobath ao n��vel dos ajustes posturais durante o alcance funcional dos membros superiores, em tr��s crian��as com paralisia cerebral. Pretende-se tamb��m, verificar o efeito desta abordagem nas atividades e participa����o, bem como destacar os aspetos individuais das mesmas crian��as com a capacidade de mudan��a ap��s a interven����o. Metodologia: A avalia����o foi realizada antes e tr��s meses ap��s a interven����o em fisioterapia segundo o conceito de Bobath. Optou-se por um registo observacional com uma M��quina Fotogr��fica Digital, um sistemas de C��maras de V��deo, uma Plataforma de For��as e, utilizaram-se ainda instrumentos como o Gross Motor Functional Measure��� vers��o 88 itens, o Gross Motor Function Classification System, o Teste de Alcance Funcional Modificado e a ferramenta, Classifica����o Internacional de Funcionalidade, Incapacidade e Sa��de ��� crian��as e jovens. Resultados: Verificou-se um progresso nos ajustes posturais e na funcionalidade em geral, o que se repercutiu na restri����o da participa����o e na limita����o da actividade. A postura na posi����o de sentado, o deslocamento do centro de press��o, a capacidade de deslocamento no sentido anterior, bem como as capacidades motoras grosseiras modificaram-se em todas as crian��as, tendo a crian��a B apresentado a maior e a crian��a A a menor capacidade de mudan��a ap��s a interven����o. Conclus��o: A interven����o segundo o Conceito de Bobath promoveu modifica����es neuromotoras, o que levaram a uma melhoria da funcionalidade geral, da mobilidade e do controlo postural da crian��a, refletindo-se nos ajustes posturais durante o alcance funcional dos membros superiores na posi����o de sentado. Verificou-se ainda, uma melhoria na restri����o da participa����o e na limita����o da actividade di��ria.

Capacidade de modificar par��metros espa��o-temporais do ciclo da marcha ap��s modifica����o de componentes intr��nsecas ao membro inferior em indiv��duos com sequelas de acidente vascular encef��lico - interven����o na reeduca����o da marcha em treadmill

Objectivo: A realiza����o deste estudo tem como objectivo identificar a capacidade de modifica����o dos par��metros do ciclo da marcha ap��s interven����o a n��vel dos componentes do membro inferior e uma abordagem na reeduca����o da marcha no tapete rolante (treadmill). M��todos: Este estudo �� um estudo de s��rie de casos, constitu��do por tr��s indiv��duos com sequelas de Acidente Vascular Encef��lico (AVE), com comprometimento a n��vel do membro inferior, capazes de realizar marcha. Os instrumentos de avalia����o foram o teste de marcha de 10 metros (10-M), o teste de marcha de 6 minutos (6-Min) e o Time Up and Go (TUG). Os indiv��duos receberam interven����o da fisioterapia baseada no conceito de Bobath e na reeduca����o de marcha no treadmill. Resultados: Ap��s a interven����o verificou-se um aumento da velocidade e cad��ncia da marcha, assim como uma maior toler��ncia e resist��ncia na capacidade da sua realiza����o. Conclus��o: A interven����o realizada a n��vel dos componentes do membro inferior e na reeduca����o da marcha utilizando o treadmill permitiu modificar alguns par��metros espa��o-temporais do ciclo da marcha, aumentando a velocidade e cad��ncia da marcha. A utiliza����o conjunta de diferentes abordagens na interven����o ao indiv��duo com sequelas de AVE deve ser sempre considerada uma vez que pode trazer benef��cios na sua independ��ncia e qualidade de vida.

General Ribeiro Arthur militar e artista

Ribeiro Arthur foi militar, cr��tico de Arte e foi sobretudo um dos mais importantes investigadores e ilustradores da hist��ria dos uniformes em Portugal. Produziu um n��mero muito significativo de aguarelas dedicadas a este tema que, reunidas em colec����o, est��o preservadas no Arquivo Hist��rico Militar. ABSTRACT - Artur Ribeiro Arthur was military, art critic and was one of the most important researchers and illustrators in the history of the uniforms in Portugal. He produced a significant number of watercolors dedicated to this theme, gathered in collections that are kept in the Military Historical Archive.

Organization knowledge management change from a complex adaptive systems perpective with ability for ambidexeterity

We are working on the confluence of knowledge management, organizational memory and emergent knowledge with the lens of complex adaptive systems. In order to be fundamentally sustainable organizations search for an adaptive need for managing ambidexterity of day-to-day work and innovation. An organization is an entity of a systemic nature, composed of groups of people who interact to achieve common objectives, making it necessary to capture, store and share interactions knowledge with the organization, this knowledge can be generated in intra-organizational or inter-organizational level. The organizations have organizational memory of knowledge of supported on the Information technology and systems. Each organization, especially in times of uncertainty and radical changes, to meet the demands of the environment, needs timely and sized knowledge on the basis of tacit and explicit. This sizing is a learning process resulting from the interaction that emerges from the relationship between the tacit and explicit knowledge and which we are framing within an approach of Complex Adaptive Systems. The use of complex adaptive systems for building the emerging interdependent relationship, will produce emergent knowledge that will improve the organization unique developing.

Epidemiolog��a de la enfermedad de Chagas, Departamento General Paz, Argentina

OBJETIVO: El objetivo del presente trabajo fue investigar la colonizaci��n por triatominos en ambientes dom��sticos y peridom��sticos y evaluar la seroprevalencia de infectados chag��sicos en localidades rurales. M��TODOS: La investigaci��n se realiz�� en General Paz, Corrientes, Argentina. Las viviendas y peridomicilios se seleccionaron mediante un muestreo simple al azar. La b��squeda de triatominos se efectu�� por el m��todo captura/hora/hombre. Los insectos se identificaron taxon��micamente y se clasificaron seg��n sexo y edad. La infecci��n por Trypanosoma cruzi se detect�� por observaci��n directa de las heces al microscopio y por la t��cnica de la reacci��n en cadena de la polimerasa (PCR). Se evaluaron serol��gicamente a pobladores voluntarios mediante las t��cnicas de hemaglutinaci��n indirecta (HAI) y ensayo inmunoenzim��tico (ELISA). Se hallaron los ��ndices de infestaci��n, densidad, colonizaci��n, infecci��n natural y dispersi��n. RESULTADOS: Se analizaron 42 viviendas y 50 peridomicilios. En el domicilio los ��ndices de infestaci��n e infecci��n de Triatoma infestans fueron 23,8 y 19,4 respectivamente. Los ��ndices de densidad, colonizaci��n y dispersi��n fueron 2,1; 47,0 y 50,0 respectivamente. La infestaci��n del peridomicilio por T. infestans fue 5,9% y por T. sordida 11,8%. T. sordida result�� infectada por Trypanosoma cruzi en un 2,0%. La seroprevalencia al T. cruzi de los 85 pacientes fue del 22,3%. CONCLUSIONES: Se estima que en el ��rea investigada la transmisi��n del T. cruzi est�� interrumpida. Sin embargo, la presencia de infectados humanos y de T. infestans parasitadas posibilitan el reinicio del ciclo de transmisi��n. Se proponen acciones de rociado con insecticidas con el objeto de eliminar las poblaciones del vector.

Factores asociados a mortalidad perinatal en el hospital general de Chiapas, M��xico

OBJETIVO: El objetivo del estudio es identificar factores socioecon��micos, gineco-obst��tricos y del producto asociados a mortalidad perinatal. M��TODOS: Se realiz�� un estudio de casos y controles pareado. Se consider�� caso a los nacidos vivos o muertos que nacieron y fallecieron entre las 28 semanas de gestaci��n a los 7 d��as de vida extrauterina. y control al producto nacido vivo entre las 28 semanas de gestaci��n y los 7 d��as de vida extrauterina. Los datos se obtuvieron de los expedientes cl��nicos hospitalarios. Se estudiaron 99 casos y 197 controles. Se hizo un an��lisis estad��stico utilizando Stata 6.0. RESULTADOS La media de edad de la madre fue de 24.82 a��os y del producto de 37.78 semanas de gestaci��n. El promedio de peso del producto fue de 2,760 gramos. Los factores asociados a mortalidad perinatal fueron: ocupaci��n del padre agricultor (RM ajustada 3,31; IC 95% 1,26-8,66); ��ndice de riesgo obst��trico alto (RM ajustada 10,57; IC 95% 2,82-39,66), antecedente de ces��rea (RM ajustada 2,75; IC 95% 1,37-5,51); cinco y m��s consultas prenatales (RM ajustada 4,43; IC 95% 1.86-10,54); producto pret��rmino (RM ajustada 9,20; IC 95% 4,39-19,25). CONCLUSIONES: Los resultados muestran que es necesario implementar medidas de prevenci��n y control que aseguren la identificaci��n del riesgo en las mujeres embarazadas, con el fin de abatir la incidencia de mortalidad perinatal.

An efficient method for optimal location and sizing of fixed and switched shunt capacitors in large distribution systems

This paper proposes a computationally efficient methodology for the optimal location and sizing of static and switched shunt capacitors in large distribution systems. The problem is formulated as the maximization of the savings produced by the reduction in energy losses and the avoided costs due to investment deferral in the expansion of the network. The proposed method selects the nodes to be compensated, as well as the optimal capacitor ratings and their operational characteristics, i.e. fixed or switched. After an appropriate linearization, the optimization problem was formulated as a large-scale mixed-integer linear problem, suitable for being solved by means of a widespread commercial package. Results of the proposed optimizing method are compared with another recent methodology reported in the literature using two test cases: a 15-bus and a 33-bus distribution network. For the both cases tested, the proposed methodology delivers better solutions indicated by higher loss savings, which are achieved with lower amounts of capacitive compensation. The proposed method has also been applied for compensating to an actual large distribution network served by AES-Venezuela in the metropolitan area of Caracas. A convergence time of about 4 seconds after 22298 iterations demonstrates the ability of the proposed methodology for efficiently handling large-scale compensation problems.

O desenvolvimento da leitura em fun����o de diferentes m��todos

Disserta����o apresentada �� Escola Superior de Educa����o de Lisboa no ��mbito do Mestrado em Ensino Especial

Combining artificial intelligence techniques for the training of power system control centre operators

Control Centre operators are essential to assure a good performance of Power Systems. Operators��� actions are critical in dealing with incidents, especially severe faults, like blackouts. In this paper we present an Intelligent Tutoring approach for training Portuguese Control Centre operators in incident analysis and diagnosis, and service restoration of Power Systems, offering context awareness and an easy integration in the working environment.

Autonomic computing for scheduling in manufacturing systems

We describe a novel approach to scheduling resolution by combining Autonomic Computing (AC), Multi-Agent Systems (MAS) and Nature Inspired Optimization Techniques (NIT). Autonomic Computing has emerged as paradigm aiming at embedding applications with a management structure similar to a central nervous system. A natural Autonomic Computing evolution in relation to Current Computing is to provide systems with Self-Managing ability with a minimum human interference. In this paper we envisage the use of Multi-Agent Systems paradigm for supporting dynamic and distributed scheduling in Manufacturing Systems with Autonomic properties, in order to reduce the complexity of managing systems and human interference. Additionally, we consider the resolution of realistic problems. The scheduling of a Cutting and Treatment Stainless Steel Sheet Line will be evaluated. Results show that proposed approach has advantages when compared with other scheduling systems.

Instrumentos de apoio �� gest��o estrat��gica e ao desempenho organizacional dos fisioterapeutas em unidades privadas de fisioterapia

Mestrado em Interven����o S��cio-Organizacional na Sa��de - ��rea de especializa����o: Pol��ticas de Administra����o e Gest��o de Servi��os de Sa��de.

Worldwide molecular epidemiology of HIV

Human immunodeficiency virus (HIV) is the worldwide disseminated causative agent of acquired immunodeficiency syndrome (AIDS). HIV is a member of the Lentivirus genus of Retroviridae family and is grouped in two types named HIV-1 and HIV-2. These viruses have a notable ability to mutate and adapt to the new conditions of human environment. A large incidence of errors at the transcriptional level results in changes on the genetic bases during the reproductive cycle. The elevated genomic variability of HIV has carried important implications for the diagnosis, treatment and prevention as well as epidemiologic investigations. The present review describes important definitions and geographical distribution of subtypes, circulating recombinant forms and other genomic variations of HIV. The present study aimed at leading students of Biomedical Sciences and public health laboratory staff guidance to general and specific knowledge about the genomic variability of the HIV.

Binocular vision and reading ability in a Portuguese population of school age children

Preventable visual loss caused by amblyopia (2 to 4%) and its risk factors such as strabismus (3%) and uncorrected refractive errors (5 to 7%) represent an important public health problem. Children with binocular vision anomalies could be at disadvantage in reading and writing. Objectives: (1) Describe binocular vision measures in children of school age; and (2) Describe the impact of abnormal binocular vision on reading ability (reading errors and reading speed).