Family portrait taken in a garden on the 75th birthday of Henriette Gottschalk nee Rothschild.

Front row, from left to right: Fritz Gottschalk, Walter Gottschalk, Kurt Gottschalk, Ursula Gottschalk, Hans Ludwig (Hal) Gottschalk, Rudolf Gottschalk, Elizabeth Gottschalk; babies, from left to right: Ilse Gottschalk, Freddy Gottschalk; adults, from left to right: Karl Gottschalk, Elisabeth Gottschalk nee Steinfeld, Ernst Gottschalk, Henriette Gottschalk nee Rothschild, Therese Gottschalk nee Molling, Fritz Joseph Gottschalk

Family portrait of the Gottschalk family; Hannover, Germany.

Front Row (l-r): Frau Steinfeld (mother of Elizabeth Gottschalk nee Steinfeld and Hela Steinfeld), Fritz Gottschalk, Karl Gottschalk, Henrietta Gottschalk nee Rothschild (mother of Fritz, Karl, Anna and Ernst), Anna Catsenstein nee Gottschalk (twin of Karl Gottschalk), and Elizabeth Gottschalk; Back Row (l-r): Hela Steinfeld (sister of Elizabeth Gottschalk nee Steinfeld), Therese Gottschalk nee Molling (wife of Fritz), Leo Catsenstein (husband of Anna), Elizabeth Gottschalk nee Steinfeld (wife of Karl), Ernst Gottschalk, and Henny Molling nee Meyerhof (mother of Therese Gottschalk nee Molling)

Fritz Gottschalk's family in front of the hotel Kurhaus Brunig, Norderney; Germany.

Digital Image

The Gottschalk family on the beach; Norderney, Germany.

(l-r) Elizabeth, Hans Ludwing (Hal), the maid, Ursula, Walter, Freddy, Therese (in Strandkorg) and Kurt standing

Fritz Gottschalk family with other children on the beach; Norderney, Germany.

Digital Image

Emanuel Lasker and Ed Lasker playing chess Portraits Family

Digital Image

Reiss family portrait; (l-r) Olga, Herbert, Flora Lotte, Walter, Moritz and Kurt; Saaz, Czechoslovakia Portraits Family

Olga Reiss nee Kohn died 1950s; Herbert Reiss, 1905-circa 1980; Flora Lotte "Lola" Reiss, 1910-1995; Walter Reiss, 1908-1937; Moritz Reiss, 1876-1965; Kurt Reiss, 1906-1996

Flora Lotte "Lola" Reiss walking in the street with her father Moritz; Karlovy Vary (Carlsbad) Portraits Family

Digital Image

Flora Lotte "Lola" Reiss walking in the street with her non-Jewish boyfriend Walter; Karlovy Vary (Carlsbad) Portraits Family

Digital Image

Reiss family on skiing trip; Arosa Portraits Family

Digital Image

Reiss family portrait on the occasion of the wedding of Harry Gould to Eva Fantl; Royal Connaught Hotel, Hamilton, Ontario.

Standing l-r: George? son of Max Reiss?, Max Reiss, Harry Gould, Moritz Reiss, Joe Reiss, and Herbert Reiss; Seated l-r: Trude Reiss (wife of Herbert), Else Reiss (mother of Joe), Lily Friedlander Gould, Eva Fantl Gould, Trude Reiss (wife of Joe), and Marta Reiss (wife of Max)

Kohnberger family portrait.

From left to right, back row: Ernst Schueller, Hermine Schueller, Laura Stiassny, Sigmund Stiassny, Martha Pollak, Johanna Mislap and Jacob Hermann; front row: Melanie Herrmann (or Irene Tiring), Conrad Tiring, Emilie Kohnberger and Solomon Kohnberger

Family portrait with Alfred Lichtenstein, his first wife Gerda, unidentified others (maman, tante, oncle, soeur).

Digital Image

Defining the role of common variation in the genomic and biological architecture of adult human height

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.

Guttmann family portrait Portraits Couples

Abraham Guttmann and Feige Taube Guttmann nee Berlowitz with their children Noah, Helmut (Koffel), Sally (Steven), Heinz and Dorothea (Dola) and an unidentified young man