Consumer Advisory: Your Credit Report & Credit Score, March 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: Your Credit Report & Credit Score

Consumer Advisory: Home Repairs & Home Improvements, April 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: Home Repairs & Home Improvements

Les observacions de classes al servei de la didàctica de la llengua estrangera

La autora revisa diferentes usos de las observaciones de clases, en particular en lo que se refiere a las clases de lengua extrangera, tanto en investigación como en formación. A partir de algunos ejemplos, identifica, entre la diversidad de formas de aplicación, objetivos diferentes y modelos de formación diversos, considerando que éstos no se excluyen sino que se complementan, según su adecuación a cada situación de formación. Se comentan algunos problemas con el fin de iniciar una reflexión sobre la aplicación de las observaciones de clase a la formación, que debería proseguir con trabajos de investigación y encuentros de formadores.

Alfabetització, cultura escrita i classes populars a l'època contemporània

Aquest article se centra en l'estudi de la relació de les classes populars amb la cultura escrita a l'època contemporània. Els exemples que s'exposen es refereixen bàsicament a la ciutat de Reus al segle XIX, tot i que també hi ha altres referències. En un primer moment s'estudia l'accés de les classes populars a la cultura escrita a través de l'escola. També hi ha una anàlisi d'alguns àmbits extraacadèmics on hom pot obtenir els mecanismes per accedir a la lectura i l'escriptura. Entre ells s'han escollit les associacions i les presons. Finalment, s'analitzen alguns testimonis escrits de les classes populars.

Consumer Advisory: Unauthorized Charges & “Free Trial” Offers, May 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: Unauthorized Charges & “Free Trial” Offers

Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported to be effective inhibitors of MIF tautomerase activity in vitro. Herein we employed a robust activity-based assay to identify different classes of novel inhibitors of the catalytic and biological activities of MIF. Several novel chemical classes of inhibitors of the catalytic activity of MIF with IC(50) values in the range of 0.2-15.5 microm were identified and validated. The interaction site and mechanism of action of these inhibitors were defined using structure-activity studies and a battery of biochemical and biophysical methods. MIF inhibitors emerging from these studies could be divided into three categories based on their mechanism of action: 1) molecules that covalently modify the catalytic site at the N-terminal proline residue, Pro(1); 2) a novel class of catalytic site inhibitors; and finally 3) molecules that disrupt the trimeric structure of MIF. Importantly, all inhibitors demonstrated total inhibition of MIF-mediated glucocorticoid overriding and AKT phosphorylation, whereas ebselen, a trimer-disrupting inhibitor, additionally acted as a potent hyperagonist in MIF-mediated chemotactic migration. The identification of biologically active compounds with known toxicity, pharmacokinetic properties, and biological activities in vivo should accelerate the development of clinically relevant MIF inhibitors. Furthermore, the diversity of chemical structures and mechanisms of action of our inhibitors makes them ideal mechanistic probes for elucidating the structure-function relationships of MIF and to further determine the role of the oligomerization state and catalytic activity of MIF in regulating the function(s) of MIF in health and disease.

Consumer Advisory: The Drive to Destroy: Removing data from computer hard drives, storage devices & wireless phones, June 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: The Drive to Destroy: Removing data from computer hard drives, storage devices & wireless phones

Aspectes metodològics i técnica d'analisi en l'estudi dels grups i les classes socials

En aquest article es presenta el procés metodològic, com també les tècniques d'anàlisi de dades, que s'ha utilitzat en l'anàisi dels grups socials mitjançant la informació d'una gran enquesta sobre hàbits i condicions de vida. L'anàlisi dels grups socials des d'una perspectiva globalitzadora i estructuradora de les condicions de vida, tenint en compte com aquests sorgeixen mitjançant I 'associació i la coherència entre múltiples característiques. Les tècniques d'anàlisi de dades que s'han utilitzat han estat l'anàlisi de correspondències múltiples i l'anàlisi de classificació.

Consumer Advisory:Student Loan “Rescue” Companies Are No Lifeline! July 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about:Student Loan “Rescue” Companies Are No Lifeline!

Consumer Advisory: The Drive to Destroy: Heath Fraud: Protecting Your Wellness and Your Wallet, August 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: The Drive to Destroy: Heath Fraud: Protecting Your Wellness and Your Wallet