How to boost EU–India relations. CEPS Policy Brief No. 341, 29 March 2016

India is an emerging player on the global stage, thanks to its growing economy and its strategic role in Asia as a balancing power. The EU cannot therefore ignore the rise of India, especially given its own aspirations to become an effective global actor – a status it has so far not managed to attain. The author of this CEPS Policy Brief argues that the EU and India need to nurture their relations, to move beyond the economic and bureaucratic limitations that currently characterise these relations and to work towards a reconciliation of different priorities that would be of benefit to both partners.

Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid

Sterile immunity against malaria can be achieved by the induction of IFNgamma-producing CD8(+) T cells that target infected hepatocytes presenting epitopes of the circumsporozoite protein (CSP). In the present study we evaluate the protective efficacy of a heterologous prime/boost immunization protocol based on the delivery of the CD8(+) epitope of Plasmodium berghei CSP into the MHC class I presentation pathway, by either a type III secretion system of live recombinant Salmonella and/or by direct translocation of a recombinant Bordetella adenylate cyclase toxoid fusion (ACT-CSP) into the cytosol of professional antigen-presenting cells (APCs). A single intraperitoneal application of the recombinant ACT-CSP toxoid, as well as a single oral immunization with the Salmonella vaccine, induced a specific CD8(+) T cell response, which however conferred only a partial protection on mice against a subsequent sporozoite challenge. In contrast, a heterologous prime/boost vaccination with the live Salmonella followed by ACT-CSP led to a significant enhancement of the CSP-specific T cell response and induced complete protection in all vaccinated mice.

Resins for the paper converter /

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Operator, organizational, direct support, and general support maintenance manual for converter, telephone signal CV-1919/G, NSN 5805-00-910-8848.

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