Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value= 4x10(-4)). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

The Spanish Pension System: Overview and Long-Term Projections

In the middle of the so-called pension crisis, the ageing of population and the sharp decrease in affiliations to Social Security are threatening the well-functioning of the Spanish public pension system. The purpose of this paper is to present the main challenges to be faced by the Spanish pension system, as well as to shed light on the main determinants that will condition the evolution of pension expenditure over GDP along the following decades. This quantitative analysis, which considers the 2011 and 2013 pension reforms, uses the latest data on the Spanish demographic, labor market and institutional factors in order to project the evolution of the system from the expenditure side up to 2060. For the purpose of analyzing the dynamics and the underlying drivers of pension expenditure, the so-called aggregate accounting approach will be utilized. The alternative scenarios proposed allow for exploring the robustness of the results within the baseline scenario, which constitutes the reference point of projections in the exercise. The analysis concludes that, by the end of the projected period, Spain will count on a similar public pension expenditure ratio as the current one.

Espainiako autonomia-erkidegoen finantza egoeraren analisia: 2008-2013 denboraldia

Espainiako autonomia erkidegoen finantza egoeraren analisia 2008-2013 denboraldian. Hizkuntza: Euskera

On some new mathematical models for infective diseases: analysis, equilibrium, positivity and vaccination controls

196 p.

Contributions to time series data mining departing from the problem of road travel time modeling

194 p.

Derecho de la Unión Europea y Concierto Económico: principios vertebradores de la autonomía tributaria foral en el marco de la Unión Europea

2 vols (1130 p.)- Publicación temporalmente embargada

Evolución y explotación de los recursos vegetales desde el Tardiglaciar en la vertiente mediterránea del País Vasco: datos antracológicos.

589 p.

Paleobotánica del epipaleolítico y mesolítico vascos

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas

Un pequeño Eros de bronce procedente del yacimiento de Mariturri (Armentia, Vitoria-Gasteiz)

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas.

Las ocupaciones rupestres en el fin de la Antigüedad. Los materiales cerámicos de Los Husos (Laguardia, Alava)

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas.

Los "medici" en la epigrafía de la Hispania romana

[ES] La epigrafía latina nos permite conocer la existencia de veintiséis médicos en Hispania, los cuales llevaron a cabo su trabajo en diferentes ámbitos y especialidades. Gracias a la información de los textos de las inscripciones podemos estudiar cuestiones como el estatus socio-jurídico propio de los individuos dedicados a esta actividad, las posibles mejoras en el nivel económico de que pudieron ser objeto o los desplazamientos inherentes al ejercicio de la profesión. La mayor concentración de epígrafes en las antiguas Emerita Augusta y Gades nos hace pensar en estas ciudades como importantes centros médicos durante la época altoimperial en Hispania.

Optimizing the Curie temperature of pseudo-binary RxR2-x ' Fe-17 (R, R ' = rare earth) for magnetic refrigeration

Several pseudo-binary RxR2-x'Fe-17 alloys (with R = Y, Ce, Pr, Gd and Dy) were synthesized with rhombohedral Th2Zn17-type crystal structure determined from x-ray and neutron powder diffraction. The choice of compositions was done with the aim of tuning the Curie temperature (T-C) in the 270 +/- 20 K temperature range, in order to obtain the maximum magneto-caloric effect around room temperature. The investigated compounds exhibit broad isothermal magnetic entropy changes, Delta S-M(T), with moderate values of the refrigerant capacity, even though the values of Delta S-M(Peak) are relatively low compared with those of the R2Fe17 compounds with R = Pr or Nd. The reduction on the Delta S-M(Peak) is explained in terms of the diminution in the saturation magnetization value. Furthermore, the Delta S-M(T) curves exhibit a similar caret-like behavior, suggesting that the magneto-caloric effect is mainly governed by the Fe-sublattice. A single master curve for Delta S-M/Delta S-M(Peak)(T) under different values of the magnetic field change are obtained for each compound by rescaling of the temperature axis.

A New Method for Feedback on the Quality of Chest Compressions during Cardiopulmonary Resuscitation

Quality of cardiopulmonary resuscitation (CPR) improves through the use of CPR feedback devices. Most feedback devices integrate the acceleration twice to estimate compression depth. However, they use additional sensors or processing techniques to compensate for large displacement drifts caused by integration. This study introduces an accelerometer-based method that avoids integration by using spectral techniques on short duration acceleration intervals. We used a manikin placed on a hard surface, a sternal triaxial accelerometer, and a photoelectric distance sensor (gold standard). Twenty volunteers provided 60 s of continuous compressions to test various rates (80-140 min(-1)), depths (3-5 cm), and accelerometer misalignment conditions. A total of 320 records with 35312 compressions were analysed. The global root-mean-square errors in rate and depth were below 1.5 min(-1) and 2 mm for analysis intervals between 2 and 5 s. For 3 s analysis intervals the 95% levels of agreement between the method and the gold standard were within -1.64-1.67 min(-1) and -1.69-1.72 mm, respectively. Accurate feedback on chest compression rate and depth is feasible applying spectral techniques to the acceleration. The method avoids additional techniques to compensate for the integration displacement drift, improving accuracy, and simplifying current accelerometer-based devices.

Disney: ideologia eta pedagogia

[eus] Ikerketa honek Walt Disney konpainiak ekoiztutako hainbat filmetan agertzen den edukia eta pertsonaiak analizatzen ditu. Pelikulak balorez eta aspektu ideologikoez beteta daude eta gizarte-ikaskuntzaren teoriaren arabera, izugarrizko eragina daukate haurren jarduteko moduan. Ideia horiek oso lotuta daude emakumezkoak gizartean hartzen duen irudiarekin, gizartean dagoen familiaren esanahiarekin eta gure gizarteko sistema politiko eta ekonomikoarekin. Beraz, animaziozko filmen aurrean umeen kritikotasuna garatzeko Lehen Hezkuntzako gelarako baliabide metodologikoa proposatzen da, umeek pantaila handian ikusten dutenaz hausnar dezaten.