995 resultados para 631
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Incluye Bibliografía
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El presente documento parte de un análisis de la situación de la salud en América Latina y el Caribe resaltando que, si bien en promedio ha mejorado, no hay duda de que existen grandes diferencias e inequidades que afectan a grupos muy amplios de la población a los que, en la práctica se les niega el acceso a servicios de salud. Con este panorama en mente se analizan en detalle experiencias innovadoras que atienden temas de salud, que se identificaron gracias al proyecto “Experiencias en innovación social en América Latina y el Caribe”, iniciativa de la CEPAL con el apoyo de la Fundación W.K. Kellogg. En particular se estudian tres programas que afectan la salud materno infantil y tres que se han dedicado a la atención de la salud de pueblo indígenas y comunidades multiculturales.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Medicina Veterinária - FMVZ
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Pós-graduação em Geociências e Meio Ambiente - IGCE
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ABSTRACT: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (P450c21, CYP21) accounts for about 95% of all CAH cases. The incidence of CYP21 gene mutations has been extensively studied in the last years, but in Brazil it has been investigated only in Southeast Brazilian patients. This study is the first report on the distribution of CYP21 mutations in patients from the Amazon region. Direct sequencing of the CYP21 gene identified at least one mutation in 96% of the studied chromosomes. The most common mutations found were IVS2-13A/C > G (36%), Q318X (12%), V281L (12%), 1760_1761insT (9%), Cluster E6 (7%), and P30L (7%). The worldwide most common mutations were identified among patients from the Amazon region at frequencies that may be expected for a population resulting from the admixture of Europeans (predominantly Portuguese), African Blacks and Amerindians, in proportions that differ from those estimated for South Brazilian populations. Interethnic mixture may explain the differences in the frequencies of some mutations between Brazilian patients from the Amazon and from the Southeast of the country. However, the differences found may also be due to variation in the number of patients with the different clinical forms of 21-hydroxylase deficiency in the studies carried out so far.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The regular practice of physical therapy is indicated as a non-pharmacological treatment of Alzheimer's disease by promoting cognitive, behavioral and functional benefits. However, little is known about the protocols with home-based motor intervention for this population. Thinking about it, this review aimed to investigate and analyze the protocols for home-based motor intervention for elderly with Alzheimer's disease described in scientific articles. A systematic search was performed in the following databases: Web of Science, PubMed, PsycINFO, and Scopus, using the following keywords and Boolean operators: home-based exercise OR home-based physical exercise OR home-based physical fitness OR home-based rehabilitation OR home-based physical therapy OR home-based physical activity OR home-based engine Intervention and AD OR Alzheimer's disease OR AlzheimerOR Alzheimer's dementia. We also conducted a manual search of reference lists of selected articles. Of the five articles that met the inclusion criteria adopted, three performed a protocol for home motor intervention, achieving good compliance with the program, improvement of general health and reduction of depressive symptoms. The other two studies were limited to describing the protocols. Although more studies are needed, with detailed protocols, this review allowed to show that protocols for home motor intervention can also produce positive effects for both patients and caregivers.
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Quantitative analysis of growth genetic parameters is not available for many breeds of buffaloes making selection and breeding decisions an empirical process that lacks robustness. The objective of this study was to estimate heritability for birth weight (BW), weight at 205 days (W205) and 365 days (W365) of age using Bayesian inference. The Brazilian Program for Genetic Improvement of Buffaloes provided the data. For the traits BW, W205 and W365 of Brazilian Mediterranean buffaloes 5169, 3792 and 3883 observations have been employed for the analysis, respectively. In order to obtain the estimates of variance, univariate analyses were conducted using the Gibbs sampler included in the MTGSAM software. The model for BW, W205 and W365 included additive direct and maternal genetic random effects, random maternal permanent environmental effect and contemporary group that was treated as a fixed effect. The convergence diagnosis was performed employing Geweke, a method that uses an algorithm from the Bayesian Output Analysis package that was implemented using R software environment. The average values for weight traits were 37.6 +/- 4.7 kg for BW, 192.7 +/- 40.3 kg for W205 and 298.6 +/- 67.4 kg for W365. The heritability posterior distributions for direct and maternal effects were symmetric and close to those expected in a normal distribution. Direct heritability estimates obtained using the modes were 0.30 (BW), 0.52 (W205) and 0.54 (W365). The maternal heritability coefficient estimates were 0.31, 0.19 and 0.21 for BW, W205 and W365, respectively. Our data suggests that all growth traits and mainly W205 and W365, have clear potential for yield improvement through direct genetic selection.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)