Iowa Commission on the Status of African-Americans Strategic Plan, 1999-2000

The Commission on the Status of African-Americans, formerly known as the Commission on the Status of Blacks, was created by statute in 1988. The nine members of the commission are appointed by the Governor and represent each region of the State where there is a significant African-American population. Meetings are open to the public. The commission sets policy for and provides direction to the Division of the Status of African-Americans within the Department of Human Rights. The division administrator is appointed by the Governor and confirmed by the Iowa Senate.

digital¡. Fifth strategic plan for UPC libraries 2012-2014

Postprint (published version)

Tissue-based immune monitoring I: tumor core needle biopsies allow in-depth interrogation of the tumor microenvironment.

We sought to assess the feasibility and reproducibility of performing tissue-based immune characterization of the tumor microenvironment using CT-compatible needle biopsy material. Three independent biopsies were obtained intraoperatively from one metastatic epithelial ovarian cancer lesion of 7 consecutive patients undergoing surgical cytoreduction using a 16-gauge core biopsy needle. Core specimens were snap-frozen and subjected to immunohistochemistry (IHC) against human CD3, CD4, CD8, and FoxP3. A portion of the cores was used to isolate RNA for 1) real-time quantitative (q)PCR for CD3, CD4, CD8, FoxP3, IL-10 and TGF-beta, 2) multiplexed PCR-based T cell receptor (TCR) CDR3 Vβ region spectratyping, and 3) gene expression profiling. Pearson's correlations were examined for immunohistochemistry and PCR gene expression, as well as for gene expression array data obtained from different tumor biopsies. Needle biopsy yielded sufficient tissue for all assays in all patients. IHC was highly reproducible and informative. Significant correlations were seen between the frequency of CD3+, CD8+ and FoxP3+ T cells by IHC with CD3ε, CD8A, and FoxP3 gene expression, respectively, by qPCR (r=0.61, 0.86, and 0.89; all p< 0.05). CDR3 spectratyping was feasible and highly reproducible in each tumor, and indicated a restricted repertoire for specific TCR Vβ chains in tumor-infiltrating T cells. Microarray gene expression revealed strong correlation between different biopsies collected from the same tumor. Our results demonstrate a feasible and reproducible method of immune monitoring using CT-compatible needle biopsies from tumor tissue, thereby paving the way for sophisticated translational studies during tumor biological therapy.

Iowa Department of Corrections 2014-2018 Strategic Plan, January 2014

The Department of Corrections has been actively engaged in strategic planning since 2004. This plan reflects the Department’s effort to align its activities and operations with the Governor’s Leadership Agenda and the principles of Accountable Government.

Iowa Department of Corrections 2015-2019 Strategic Plan, January 2015

The Department of Corrections has been actively engaged in strategic planning since 2004. This plan reflects the Department’s effort to align its activities and operations with the Governor’s Leadership Agenda and the principles of Accountable Government.

Iowa Department of Corrections, Strategic Plan 2015-2019, January 2015

Iowa’s adult correctional system carries out its legal mandate of protecting the public and promoting offender rehabilitation through a continuum of institution and community evidence based services and interventions. This continuum is designed with recognition that for most offenders, reentry planning starts upon admission to the corrections system. The effective and efficient management of offenders in accordance with their risk and carcinogenic needs (those needs that contribute to criminality) is accomplished through targeted programming, release preparation, and transition services. Success in these endeavors assists offenders to become productive members of the community and makes it less likely that they will re-offend, resulting in lowered recidivism rates. In 1990 the Department’s prison recidivism rate was 44.7% and today it is 30.3%. Our overall desired outcome is to reduce the prison recidivism rate to 25% during the next five years by focusing resources toward our highest risk offenders.

Iowa Department of Banking 2014-2018 Strategic Plan, April 2014

This report outlines the strategic plan for Iowa Alcoholic Beverages Division including, goals and mission.

Iowa Alcoholic Beverages Division Four Year Strategic Plan 2013-2015, January 2, 2015

Iowa Alcoholic Beverages Division Strategic Plan

Iowa Insurance Division Four Year Strategic Plan FY13, October 2012

Strategic Plan for the Iowa Insurance Division

Iowa Department of Human Services Strategic Plan FY2015-2017, April 18, 2014

The Department of Human Services (DHS) provides services to over 900,000 Iowans on an annual basis this is the strategic plan.

Iowa National Guard, Strategic Plan, 2010-2015

This report outlines the strategic plan for Iowa National Guard, goals and mission.

Iowa Department of Commerce-Division of Credit Unions 2014-2018 Strategic Plan, April 2014

This report outlines the strategic plan for Iowa Division of banking including, goals and mission.

Iowa Department of Veterans Affairs, Strategic Plan FY2011-2015

This report outlines the strategic plan for Iowa Veterans Home, goals and mission.

Raman analysis of multilayer automotive paints in forensic science: measurement variability and depth profile?

The aim of this work is to study the influence of several analytical parameters on the variability of Raman spectra of paint samples. In the present study, microtome thin section and direct (no preparation) analysis are considered as sample preparation. In order to evaluate their influence on the measures, an experimental design such as 'fractional full factorial' with seven factors (including the sampling process) is applied, for a total of 32 experiments representing 160 measures. Once the influence of sample preparation highlighted, a depth profile of a paint sample is carried out by changing the focusing plane in order to measure the colored layer under a clearcoat. This is undertaken in order to avoid sample preparation such a microtome sectioning. Finally, chemometric treatments such as principal component analysis are applied to the resulting spectra. The findings of this study indicate the importance of sample preparation, or more specifically, the surface roughness, on the variability of the measurements on a same sample. Moreover, the depth profile experiment highlights the influence of the refractive index of the upper layer (clearcoat) when measuring through a transparent layer.