Activities of the ECLAC Secretariat relating to the integration of women into the economic and social development of Latin America and the Caribbean from 1 July 2000 to 30 June 2001

Includes bibliography

Estrogenic and chemopreventive activities of xanthones and flavones of Syngonanthus (Eriocaulaceae)

The possible benefits of some bioactive flavones and xanthones present in plants of the genus Syngonanthus prompted us to screen them for estrogenic activity. However, scientific research has shown that such substances may have undesirable properties, such as mutagenicity, carcinogenicity and toxicity, which restrict their use as therapeutic agents. Hence, the aim of this study was to assess the estrogenicity and mutagenic and antimutagenic properties. We used recombinant yeast assay (RYA), with the strain BY4741 of Saccharomyces cerevisiae, and Ames test, with strains TA100, TA98, TA97a and TA102 of Salmonella typhimirium, to evaluate estrogenicity, mutagenicity and antimutagenicity of methanolic extracts of Syngonanthus dealbatus (S.d.), Syngonanthus macrolepsis (S.m.), Syngonanthus nitens (S.n.) and Syngonanthus suberosus (S.s.), and of 9 compounds isolated from them (1 = luteolin, 2 = mix of A-1,3,6-trihydroxy-2-methoxyxanthone and B-1,3,6-trihydroxy-2,5- dimethoxyxanthone, 3 = 1,5,7-trihydroxy-3,6-dimethoxyxanthone, 4 = 1,3,6,8-tetrahydroxy-2,5-dimethoxyxanthone, 5 = 1,3,6,8-tetrahydroxy-5- methoxyxanthone, 6 = 7-methoxyluteolin-8-C-β-glucopyranoside, 7 = 7-methoxyluteolin-6-C-β-glucopyranoside, 8 = 7,3′-dimethoxyluteolin- 6-C-β-glucopyranoside and 9 = 6-hydroxyluteolin). The results indicated the estrogenic potential of the S. nitens methanol extract and four of its isolated xanthones, which exhibited, respectively, 14.74 ± 1.63 nM; 19.54 ± 6.61; 7.20 ± 0.37; 6.71 ± 1.02 e 10.01 ± 4.26 nM of estradiol-equivalents (EEQ). None of the extracts or isolated compounds showed mutagenicity in any of the test strains and all of them showed antimutagenic potential, in particular preventing mutations caused by aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P). The results show that the xanthones, only isolated from the methanol extract of S. nitens capitula, probably were the responsible for its estrogenic activity and could be useful as phytoestrogens, providing a new opportunity to develop hormonal agents. In addition, flavones and xanthones could also be used as a new antimutagenic agent. Since, the mutagens are involved in the initiation and promotion of several human diseases, including cancer, the significance of novel bioactive phytocompounds in counteracting these pro-mutagenic and carcinogenic effects is now gaining credence. © 2013 Elsevier Inc. All rights reserved.

Actividades de la Secretaría de la CEPAL con relación a la integración de la mujer en el desarrollo económico y social de América Latina y el Caribe = Activities of the ECLAC Secretariat with respect to the integration of women into economic and social development of Latin America and the Caribbean

Incluye Bibliografía

Actividades de la Secretaría de la CEPAL con relación a la integración de la mujer en el desarrollo económico y social de América Latina y el Caribe desde el 1o de mayo hasta el 15 de noviembre de 1990 = Activities of the ECLAC Secretariat in the area of the integration of women into the economic and social development of Latin America and the Caribbean, 1 May-15 November 1990

Incluye Bibliografía

Actividades de la Secretaría de la CEPAL relacionadas con la integración de la mujer en el desarrollo económico y social de América Latina y el Caribe desde el 1 de julio de 1988 hasta el 31 de mayo de 1991 = Activities of the ECLAC Secretariat from 1 July 1988 to 31 May 1991 relating to the integration of women into the economic and social development of Latin America and the Caribbean

Incluye Bibliografía

Actividades de la Secretaría de la CEPAL relacionadas con la integración de la mujer en el desarrollo económico y social de América Latina y el Caribe desde el 1o de junio de 1991 hasta el 31 de mayo de 1992 = Activities of the ECLAC Secretariat from 1 June 1991 to 31 May 1992 relating to the integration of women into the economic and social development of Latin America and the Caribbean

Incluye Bibliografía

Actividades de la Secretaría de la CEPAL relacionadas con la integración de la mujer en el desarrollo económico y social de América Latina y el Caribe desde el 1o de junio de 1992 hasta el 1o abril de 1993 = Activities of the ECLAC Secretariat from 1o June 1992 to 1o April 1993 relating to the integration of women into the economic and social development of Latin America and the Caribbean

Incluye Bibliografía

Report on activities of the Caribbean Council for Science and Technology: Workshop on Methodology for Assessment of National Science and Technology Capabilities

Informe de la reunion sobre metodologia para la evaluacion de las capacidades nacionales en ciencia y tecnologia, realizada en Suriname, del 12 al 15 de octubre de 1981. Presenta un resumen de los debates, conclusiones y recomendaciones.

Informe de actividades del Consejo del Caribe de Ciencia y Tecnología (CCCT), 1981-1982 = Report of the activities of the Caribbean Council for Science and Technology (CCST), 1981-1982

Describe las actividades realizadas por el Consejo del Caribe para la Ciencia y la Tecnologia, desde noviembre de 1981 a diciembre de 1982. Incluye el informe de la segunda reunion plenaria del Consejo, llevada a cabo en Kingston, Jamaica, del 3 al 5 de noviembre de 1982.

A brief overview of economic activities of Caribbean countries, 1988

Includes bibliography

Report to the Caribbean Development and Co-operation Committee (CDCC) on activities of the Caribbean Council for Science and Technology (CCST) for the period 1984-1990

Describe los objetivos del CCCT, su programa de trabajo, proyectos, y actividades realizadas entre 1984 y 1990.

Synthesis, characterization, x-ray structure, DNA cleavage, and cytotoxic activities of palladium(ii) complexes of 4-phenyl-3-thiosemicarbazide and triphenylphosphane

Complexes of the type [PdX(PPh3)(1)]X [1 = 4-phenyl-3- thiosemicarbazide; X = Cl- (2), Br- (3), I- (4), and SCN- (5)] have been synthesized and characterized by elemental analyses and IR, UV/Vis, and 1H and 13C NMR spectroscopy. The molecular structure of complex 4 was determined by single-crystal X-ray diffraction. The binding of the complexes with a purine base (guanosine) was investigated by 1H NMR spectroscopy and mass spectrometry, which showed the complexes to coordinate to guanosine through N7. A gel electrophoresis assay demonstrated the ability of 2-5 to cleave DNA plasmid. All the complexes were tested in vitro by means of the MTT assay for their cytotoxicity against two murine cell lines, LM3 (mammary adenocarcinoma) and LP07 (lung adenocarcinoma), and compared with cisplatin. Complexes 2-5 exhibited good cytotoxicity that surpasses that of cisplatin in the case of LM3. A series of thiosemicarbazide/phosphane palladium(II) complexes have been synthesized and fully characterized. These complexes are able to cleave DNA plasmid and show cytotoxicity against adenocarcinoma (mammary LM3 and lung LP07), surpassing the cytotoxicity of cisplatin in the case of LM3. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Report on activities of the Caribbean Council for Science and Technology

Informe de la Primera Sesión Plenaria del Consejo del Caribe para Ciencia y Tecnología y subsiguientes actividades en la implementación de las decisiones del Consejo. Contiene guías para el programa de trabajo (1981-1983).

Information activities of the Latin American Demographic Centre (ECLAC

Includes bibliography