1000 resultados para Teste de função respiratória Avaliação
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The human respiratory system was so designed that would allow efficient ventilation, regardless of variations in the external environment that may hinder the act of breathing, such an act involves dozens of variables, among them we find the respiratory depression, which is nothing more than respiratory muscle strength. The pressures are widely used in several cases: Neuro-muscular; evolution of pulmonary dysfunction and a predictor for discontinuation of mechanical ventilation. Therefore it was proposed to carry out evaluations of these respiratory pressures for children and adolescents aged 10 to 16 years and propose a predictive equation that involves the anthropometric variables age (A, years), body mass (BM, kilograms) and height (H, meters) with maximal respiratory pressures (maximum inspiratory and expiratory pressure). Evaluations were performed in this age group of students in public and private schools of the Grande Natal , measurements were performed using the analogue manometer, were children and adolescents and their parents gave informed consent. 517 samples were taken, and 250 for males (M), 255 for females (F) and 12 were excluded according to our exclusion criteria. The sample was subdivided into three age groups (10-11, 12-13 and 14 to 16 years old). It was found through the student s t test (p ≤ 0.05) for all variables studied, children and male adolescents had higher means than females, except for the MC. For the correlation between the variables found significant correlation (p <0.05) among all the variables when analyzed as pairs except between MIP and height for females. The development of predictive equations (for p ≤ 0.05) based on three types of strategies adopted were restricted to two association between anthropometric variables isolated, resulting in: for males: MIP = -32.29 + (-2.11*A) + (-0.52*BM), MIP = 9.99 + (-0.36*BM) + (-49.40*H); MEP = 18.54 + 3.53*A + 0, 42*BM, MEP = -33.37 + 2.78*A + 52.18* H, MEP = -17.39 + 0.33*BM + 55.04*H; and, for females we find: MEP = 24.32 + 2.59 * A + 0.24*BM
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Tamoxifen (TX), a drug used in the treatment of breast cancer, may cause hepatic changes in some patients. The consequences of its use on the liver tissues of rats with or without diabetes mellitus (DM) have not been fully explored. The purpose of this multidisciplinary study was to evaluate the correlation between plasma hepatic enzyme levels and the presence of iron overload in the hepatic tissue of female Wistar rats with or without streptozotocin-induced DM and using TX. Female rats were studied in control groups: C-0 (non-drug users), C-V (sorbitol vehicle only) and C-TX (using TX). DM (diabetic non-drug users) and DM-TX (diabetics using TX) were the test groups. Sixty days after induced DM, blood samples were collected for glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST) alkaline phosphatase (ALP) and bilirubin measures. Hepatic fragments were processed and stained with hematoxylin and eosin (H&E), Masson s trichrome, Perls. The hepatic iron content was quantified by atomic absorption spectrometry. AST, ALT and ALP levels were significantly elevated in the DM and DM-TX groups, with unchanged bilirubin levels. Liver iron overload using Perls stain and atomic absorption spectrometry were observed exclusively in groups C-TX and DM-TX. There was positive correlation between AST, ALT and ALP levels and microscopic hepatic siderosis intensity in group DM-TX. In conclusion, TX administration is associated with liver siderosis in diabetic and non-diabetic rats. In addition, TX induced liver iron overload with unaltered hepatic function in 2 non-diabetic rats and may be a useful tool for investigating the biological control of iron metabolism
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Alterations in the neuropsychomotor development of children are not rare and can manifest themselves with varying intensity at different stages of their development. In this context, maternal risk factors may contribute to the appearance of these alterations. A number of studies have reported that neuropsychomotor development diagnosis is not an easy task, especially in the basic public health network. Diagnosis requires effective, low-cost, and easy - to-apply procedures. The Denver Developmental Screening Test, first published in 1967, is currently used in several countries. It has been revised and renamed as the Denver II Test and meets the aforementioned criteria. Accordingly, the aim of this study was to apply the Denver II Test in order to verify the prevalence of suspected neuropsychomotor development delay in children between the ages of 0 and 12 months and correlate it with the following maternal risk factors: family income, schooling, age at pregnancy, drug use during pregnancy, gestational age, gestational problems, type of delivery and the desire to have children. For data collection, performed during the first 6 months of 2004, a clinical assessment was made of 398 children selected by pediatricians and the nursing team of each public health unit. Later, the parents or guardians were asked to complete a structured questionnaire to determine possible risk indicators of neuropsychomotor development delay. Finally the Denver II Developmental Screening Test (DDST) was applied. The data were analyzed together, using Statistical Package for Social Science (SPSS) software, version 6.1. The confidence interval was set at 95%. The Denver II Test yielded normal and questionable results. This suggests compromised neuropsychomotor development in the children examined and deserves further investigation. The correlation of the results with preestablished maternal risk variables (family income, mother s schooling, age at pregnancy, drug use during the pregnancy and gestational age) was strongly significant. The other maternal risk variables (gestational problems, type of delivery and desire to have children) were not significant. Using an adjusted logistic regression model, we obtained the estimate of the greater likelihood of a child having suspected neuropsychomotor development delay: a mother with _75 4 years of schooling, chronological age less than 20 years and a drug user during pregnancy. This study produced two manuscripts, one published in Acta Cirrgica Brasileira , in which an analysis was performed of children with suspected neuropsychomotor development delay in the city of Natal, Brazil. The other paper (to be published) analyzed the magnitude of the independent variable maternal schooling associated to neuropsychomotor development delay, every 3 months during the first twelve months of life of the children selected.. The results of the present study reinforce the multifactorial characteristic of development and the cumulative effect of maternal risk factors, and show the need for a regional policy that promotes low-cost programs for the community, involving children at risk of neuropsychomotor development delay. Moreover, they suggest the need for better qualified health professionals in terms of monitoring child development. This was an inter- and multidisciplinary study with the integrated participation of doctors, nurses, nursing assistants and professionals from other areas, such as statisticians and information technology professionals, who met all the requirements of the Postgraduate Program in Health Sciences of the Federal University of Rio Grande do Norte
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Objective: The purpose of this study was to investigate the kinetics of this micronutrient in schoolchildren between the ages of 6 and 9 years, of both sexes, and to verify its sensitivity in detecting alterations in body zinc status. Methods: Nutritional assessment was performed by body mass index. Food intake, venous zinc tolerance test and zinc kinetics were carried out before and after 3-month oral zinc supplementation. Results: Of the 42 children studied, 76.2% had healthy weight. Only energy, calcium and fiber intake were suboptimal before and after oral zinc supplementation. Serum zinc and total-body zinc clearance, although at normal levels, increased significantly after zinc supplementation. Conclusion: We concluded, therefore, that kinetics is a sensitive tool for detecting changes in body zinc status, even in children without a deficiency of this mineral. Furthermore, kinetics showed a positive response to supplementation and may be a sensitive parameter to evaluate the efficacy of this therapy
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A escassez de instrumentos para a avaliação e a triagem da doena de Alzheimer, (DA), notadamente denominados de rastreio, com caractersticas de padronizao e validados para o Nordeste, motivou este Estudo. Visando triagem de uma etapa mais leve da doena e encaminhamento precoce ao tratamento multidisciplinar foi elaborado o Teste de Rastreio da Doena de Alzheimer com Provrbios (TRDAP), a partir de um Jogo de Memria de Provrbios, construdo como recurso teraputico ocupacional. Est composto de trs etapas conforme a função neuropsicolgica avaliada, a A (memria de curto prazo), B (funes executivas e linguagem) e C (memria episdica), alm do reconhecimento de provrbios. O Estudo foi realizado em uma amostra de convenincia, com 91 idosos (28 DA e 63 controles), a partir de 60 anos, com um ou mais anos de escolaridade. Foram controladas as variveis, como doenas intercorrentes ou dficits sensoriais que pudessem comprometer o desempenho dos pacientes, nos testes. O protocolo constou de oito testes selecionados por especialistas: Miniexame do Estado Mental (para validade convergente), Escala de Depresso Geritrica EDG (validade discriminante), Lista de Palavras, Fluncia Verbal, Span de Dgitos, Figura Neuropsi, Teste do Relgio, Atividade de Vida Diria e Instrumental. Os resultados confirmaram a validade de construto convergente e discriminante, assim como a relao significativa (p<0,005) com todos os testes, exceto com o EDG. Quanto validade concorrente, no houve discordncia com o critrio da avaliação mdica observou-se consistncia interna aceitvel, conferindo confiabilidade no instrumento, o que no ocorreu com MEEM. Tais resultados permitem afirmar que o TRDAP possui caractersticas psicomtricas, adequadas ao rastreio da fase leve da DA para populao estudada
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Contextualization: Several studies have examined the mobility of this group of children, however little is known about the impact of motor function in activities of daily living, considering the seriousness of their neuromotor damage. Objective: Identify the functional differences of children with Cerebral Palsy with different levels of motor dysfunction and correlate these differences with the areas of mobility, self-care and social function in functional ability and caregivers assistance of these children. Methods: An l analytical cross-section search was developed, which were part 70 children / families aged from 4 to 7.5 years, in the Rehabilitation Center for Children. As tools were used the Pediatric Evaluation Disability Inventory (PEDI) and the Gross Motor Function Classification System (GMFCS). Data analysis was performed by ANOVA and Pearson's correlation tests. Results: The results show the functional variability of children CP in different severity levels of motor disfunction This variation was observed in the areas of mobility, self-care and social function. The results also showed a strong correlation between the domains mobility and self-care, mobility and social function. Conclusions: The variability shown by the children with CP, suggests the use of PEDI and GMFCS as this association appears to increase the understanding of how the gross motor functions are related to activities of daily living, describing the best commitments and their degree of impact on functional activities. This correlation demonstrates how mobility is crucial to evaluate the performance and guide the therapeutic practice, to develop the childrens potencial, and guide the caregiver in stimulation
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Sulfated polysaccharides (SP) are widely distributed in animals and seaweeds tissues. These polymers have been studied in light of their important pharmacological activities, such as anticoagulant, antioxidant, antitumoral, anti-inflammatory, and antiviral properties. On other hand, SP potential to synthesize biomaterials like as nanoparticules has not yet been explored. In addition, to date, SP have only been found in six plants and all inhabit saline environments. However, the SP pharmacological plant activities have not been carrying out. Furthermore, there are no reports of SP in freshwater plants. Thus, do SP from marine plants show pharmacological activity? Do freshwater plants actually synthesize SP? Is it possible to synthesize nanoparticles using SP from seaweed? In order to understand this question, this Thesis was divided into tree chapters. In the first chapter a sulfated polysaccharide (SPSG) was successfully isolated from marine plant Halodule wrightii. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan contains glucose and xylose. Several assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane in the aPTT test; in the next chapter using different tools such as chemical and histological analyses, energy-dispersive X-ray analysis (EDXA), gel electrophoresis and infra-red spectroscopy we confirm the presence of sulfated polysaccharides in freshwater plants for the first time. Moreover, we also demonstrate that SP extracted from E. crassipes root has potential as an anticoagulant compound; and in last chapter a fucan, a sulfated polysaccharide, extracted from the brown seaweed was chemically modified by grafting hexadecylamine to the polymer hydrophilic backbone. The resulting modified material (SNFuc) formed nanosized particles. The degree of substitution for hydrophobic chains of 1H NMR was approximately 93%. SNFfuc-TBa125 in aqueous media had a mean diameter of 123 nm and zeta potential of -38.3 0.74 mV, measured bydynamic light scattering. Tumor-cell (HepG2, 786, H-S5) proliferation was inhibited by 2.0 43.7% at SNFuc concentrations of 0.05 0.5 mg/ mL and RAEC non-tumor cell line proliferation displayed inhibition of 8.0 22.0%. On the other hand, nanogel improved CHO and RAW non-tumor cell line proliferation in the same concentration range. Flow cytometric analysis revealed that this fucan nanogel inhibited 786 cell proliferation through caspase and caspaseindependent mechanisms. In addition, SNFuc blocks 786 cell passages in the S and G2-M phases of the cell cycle
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Este estudo teve por objetivo avaliar os fatores associados disfunção sexual em mulheres de meia idade. Realizou-se um estudo descritivo transversal, que compreendeu 370 mulheres, entre 40 a 65 anos, atendidas nas Unidades Bsicas de Sade de cada distrito sanitrio (Norte, Sul, Leste e Oeste) da cidade de Natal, no estado do Rio Grande do Norte, Brasil. Para avaliar a função sexual utilizou-se o Female Sexual Function Index (FSFI). A sintomatologia climatrica foi avaliada por meio do Menopause Rating Scale (MRS). O ndice de Blatt-Kupperman (IMBK) foi utilizado para avaliação quantitativa global da ocorrncia de sintomas/queixas. A atividade fsica foi avaliada pelo questionrio International Physical Activity Questionnaire - IPAQ (verso curta). A avaliação da qualidade de vida geral se deu pelo WHOQOL-Bref. A anlise estatstica foi realizada utilizando o programa estatstico MINITAB version16. Alm de anlises descritivas das variveis categorizadas, utilizou-se o teste qui-quadrado de Person com o intuito de verificar possveis associaes entre as variveis sociodemogrficas, comportamentais, clnicas, nveis de atividade fsica, sintomatologia climatrica, qualidade de vida e a função sexual das mulheres estudadas. Desenvolveu-se a regresso logstica para verificar a influncia dessas variveis sobre a disfunção sexual. Considerou-se o nvel de significncia de 5% para todos os testes. Os resultados mostraram que a mdia de idade das mulheres estudadas foi de 49,8 (8,1) anos. Do total dessas mulheres, 67% apresentaram disfunção sexual. Observou-se que 54,5% delas se encontravam na pr-menopausa. Avaliando a influncia das variveis sobre a função sexual; faixa etria (56-65) (p<0,001), estado civil (divorciada/separada) (p < 0,001), escolaridade (baixa) (p=0,017), menopausa (p < 0,001), histerectomia (p = 0,016), nvel de atividade fsica (sedentria) (p=0,002), sintomas do climatrio (forte) (p<0,001) e qualidade de vida (baixa) (p<0,001), estiveram associados disfunção sexual em mulheres de meia idade. Concluiu-se neste estudo que fatores sociodemogrficos, clnicos, comportamentais, nveis de atividade fsica, sintomatologia climatrica e qualidade de vida influenciam significativamente a função sexual na mulher de meia idade
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A hemiparesia consiste no dficit da fora muscular, com consequente debilidade na mo e no p, afetando um dos lados do corpo. A literatura mostra poucos estudos enfocando detalhadamente as funes cognitivas e emocionais de crianas afetadas por essa condio neurolgica. Este estudo teve como objetivo realizar avaliação neuropsicolgica de 23 crianas e adolescentes, de ambos os gneros, com idades entre 5 anos e 4 meses e 16 anos e 6 meses, com hemiparesia congnita e adquirida. Aplicou-se uma bateria de testes especfica para avaliação de funes cognitivas superiores incluindo processos intelectuais, ateno, função perceptiva, função motora, praxias, gnosias, linguagem, memria e função visuomotora. Em relao aos aspectos emocionais, foi usado o teste do desenho da figura humana, visando-se a avaliação da percepo da imagem corporal dos pacientes. Os resultados mostraram que a hemiparesia da criana conduz a dficits em funes neuropsicolgicas importantes, alm de dficit motor e alteraes na esfera emocional, mais precisamente aquelas relacionadas com a representao da imagem corporal. A abrangncia multidisciplinar, envolvendo a neurologia peditrica e a psicologia, engrandeceu o trabalho, referendando os resultados obtidos em todos os seus aspectos
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Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)
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O trabalho teve por objetivo avaliar o teste imunoenzimtico competitivo (CEIA) para uso no diagnstico sorolgico da brucelose em bfalos (Bubalus bubalis), comparando seus resultados com aqueles obtidos na reao de fixao de complemento (CFT) e no teste rosa Bengala (RBT). Foram examinados 477 soros por meio do CEIA e do RBT e 465, desses mesmos soros, por meio da CFT. Na CFT e no CEIA, soros com ttulos maiores ou iguais a 1/4 foram considerados positivos. Para a determinao da sensibibilidade e da especificidade relativas do CEIA, foram considerados como doentes os animais com resultados positivos no RBT e na CFT e sos os animais com resultados negativos nesses dois testes. Soros com resultados discordantes nesses duas provas foram eliminados da anlise. Os resultados apontaram uma concordncia de 97,42% entre o CEIA e a CFT e uma concordncia de 95,39% entre o CEIA e o RBT. A sensibilidade relativa do CEIA foi de 100% e a especificidade relativa do teste foi de 98,55%. Esses dados mostram que o desempenho do CEIA diferiu pouco do desempenho dos outros dois testes, sugerindo que o mesmo pode constituir um recurso til para o diagnstico sorolgico da brucelose em bfalos.
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Introduction: The emergence of High Active Antiretroviral Therapy (HAART) increase the life expectancy of the persons living with HIV/AIDS (PLHIV), therefore the prolonged use cause metabolic implications and influences on body fat distribution and increase the cardiovascular diseases prevalence. Aims: Evaluate the effect of resistance training on heart rate variability, biochemical parameters and somatotype on PLHIV. Methods: Participated this study seven sedentary men, with age above 25 years old, living with HIV/AIDS, under HAART use. Were submitted a 16 week intervention with resistance training. Evaluated the heart rate variability, biochemical parameters and somatotype, before, after 8 weeks and 16 weeks, all in paired form. It was found the data normality by Shapiro-Wilk test and conducted the Anova one way combined with Tukey post hoc to samples in each evaluate moment, adopting significance level p<0,05. Also were calculated percentage change deltas. For somatotype was used the somatotype spatial distance (DES), obeying the significance value DES≥1. Results: Was found significance differences only in variable final heart rate delta 60s (p=0,01), however, is not showed changes on heart rate variability, biochemical parameters and somatotype components. Conclusion: 16 weeks of resistance training showed improvement on heart rate recovery after submaximal effort and, despite is not enough to produce significance differences on biochemical parameters and somatotype components, could be realize improvement on average value of fasting glucose and lipid profile, as well as reducing the endomorphic component
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O teste de condutividade eltrica da soluo de embebio recomendado para avaliar o vigor de sementes de ervilha e indicado para outras espcies, mas ainda h necessidade da continuidade de estudos sobre o assunto. A presente pesquisa foi desenvolvida com o objetivo de comparar procedimentos no teste de condutividade eltrica para avaliar o potencial fisiolgico de sementes de abobrinha. Utilizaram-se sementes de abobrinha (Cucurbita pepo L.), cultivar Menina Brasileira, representadas por quatro lotes na primeira etapa e por outros cinco, na segunda. Foram conduzidos os teste de germinao, primeira contagem de germinao, emergncia de plntulas, ndice de velocidade de emergncia e de condutividade eltrica. Para o teste de condutividade foram estudadas variaes no volume de gua (50 e 75mL), na temperatura (20, 25 e 30C) e no tempo de embebio (1, 2, 4, 8, 12, 16, 20 e 24 horas). O tempo de embebio para o teste de condutividade eltrica pode ser reduzido para 8 horas. Independentemente do volume de gua, a temperatura de 30C foi a mais favorvel para a ordenao consistente dos lotes quanto ao vigor. Assim, conclue-se que a condio mais adequada para o teste de condutividade eltrica em sementes de abobrinha a utilizao de 50 sementes em 75mL de gua por oito horas, a 30C.
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O vigor de sementes de amendoim (Arachis hypogaea L.) avaliado pelo teste de condutividade eltrica demonstra estreita relao com o desempenho no campo, mas alguns fatores podem afetar o resultado da condutividade eltrica, sendo um destes o teor de gua inicial das sementes. Assim, o objetivo deste trabalho foi avaliar o teor de gua ou faixa de umidade da semente mais adequado para a avaliação da condutividade eltrica em sementes de amendoim. Quatro lotes de sementes da cultivar 'IAC Tatu ST' e quatro da cultivar 'IAC Runner 886' foram avaliados quanto ao seu potencial fisiolgico e posteriormente o teor de gua foi ajustado para 5, 7, 9, 11, 13 e 15%, pelo mtodo da atmosfera mida. O delineamento foi inteiramente casualizado em esquema fatorial 46 (lotes teores de gua) para as sementes de cada cultivar, em quatro repeties e os resultados para o fator teor de gua foram submetidos anlise de regresso. A maior relao da condutividade eltrica com vigor das sementes ocorreu naquelas com teor de gua entre 9 a 15%, de forma que sementes com 5 a 7% de umidade no devem ser submetidas ao teste de condutividade eltrica, porque os lotes expressam alto padro de germinao e vigor. A condutividade eltrica de sementes de amendoim influenciada pelo teor de gua e a estabilizao dos resultados ocorre quando elas esto com teor de gua entre 10 e 14%.
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A utilizao de sementes para formao de gramados esportivos e ornamentais tem assumido grande importncia no Brasil, principalmente pelo baixo custo em relao formao por placas de tapetes naturais. As bermudas [Cynodon dactylon (L.) Pers] so as principais gramas utilizadas na formao de campos esportivos e, dentre os problemas enfrentados, destaca-se a dificuldade de estabelecimento adequado da cultura, fato que exige a utilizao de sementes de alto potencial fisiolgico, de modo a permitir rpida emergncia e desenvolvimento das plantas. Assim, estudaram-se procedimentos para a conduo do teste de envelhecimento acelerado para determinar o potencial fisiolgico de sementes dessa espcie, incluindo a avaliação da eficincia do uso de soluo saturada de NaCl como alternativa para a realizao do teste. Para tanto, cinco lotes de sementes foram submetidos aos testes de germinao, emergncia de plntulas e envelhecimento acelerado (perodos de 48, 72 e 96 h, a 41 e 45 C, com e sem o uso de soluo saturada de NaCl). O experimento foi conduzido em delineamento inteiramente casualizado. O envelhecimento acelerado com o uso de soluo saturada de NaCl, dentre os procedimentos estudados, o mtodo mais adequado para avaliação do potencial fisiolgico de sementes de grama-bermuda, sendo que a combinao 45 C/48 h eficiente para a classificao dos lotes em diferentes nveis de vigor.