989 resultados para Santillana, Íñigo López de Mendoza, Marqués de, 1398-1458


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The grape is considered a major source of phenolic compounds when compared to other fruits and vegetables, however, there are many cultivars with distinct characteristics directly linked to phenolic profile. Thus, the present study aimed to identify and quantify, for the first time and in detail, the phenolic compounds present in the skin, flesh and seeds of BRS Violeta grape berry using combination of SPE methodologies and analytical HPLC-DAD-ESI-MS/MS. The study was extended to the different berry parts and the most important grape and wine phenolic families, and has revealed interesting features. Violeta grape has a very thick skin (46% of grape weight) that accumulated the most of grape phenolic compounds: great amount of anthocyanins (3930. mg/kg, as malvidin 3,5-diglucoside), together with also important amounts of flavonols (150. mg/kg, as quercetin 3-glucoside), hydroxycinnamic acid derivatives (HCAD; 120. mg/kg, as caftaric acid), and proanthocyanidins (670. mg/kg, as (+)-catechin); in contrast, it seems to be a low resveratrol producer. Violeta grape seeds accounted for similar proportions of low molecular weight flavan-3-ols (mainly monomers; 345. mg/kg, as (+)-catechin) and proanthocyanidins (480. mg/kg, as (+)-catechin). Violeta grape is a teinturier cultivar, but it only contained traces of anthocyanins and low amounts of all the other phenolic types in its red-colored flesh. The anthocyanin composition of Violeta grape was dominated by anthocyanidin 3,5-diglucosides (90%). Within flavonols, myricetin-type predominated and kaempferol-type was missing. In addition to expected hydroxycinnamoyl-tartaric acids, several isomeric esters of caffeic and p-coumaric acids with hexoses were tentatively identified, accounting for relevant proportions within the pool of HCAD. Although pending of further confirmation over successive vintages, the aforementioned results suggest that BRS Violeta grape cultivar could be considered an interesting candidate for the elaboration of highly colored and antioxidant-rich grape juices and wines. © 2013 Elsevier Ltd.

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En el marco de una crítica a los criterios de categorización de lo urbano y lo rural, el análisis se centra en la estructura etárea de la población de Mendoza tomando como ejemplo los departamentos con mayoría rural y mayoría urbana a partir del enfoque demográfico tradicional, para luego comparar con la evolución de la población económicamente activa agropecuaria.

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Incluye Bibliografía

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Pós-graduação em Letras - FCLAS

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Mendoza y San Juan son las provincias de la región de Cuyo con recursos hídricos de origen netamente cordilleranos. El hidrograma de los ríos cuyanos se está modificado debido principalmente al aumento de la temperatura. De incrementarse la tendencia observada en la temperatura esta alteración podría tener un alto impacto en el manejo y regulación de los caudales. En este documento se muestran los resultados de dos estudios para esta región. El primero evalúa el comportamiento de las tendencias en la variabilidad de las precipitaciones, la temperatura, los caudales y el hidrograma frente a escenarios de cambio climático. Las cuencas más afectadas serían aquellas ubicadas hacia el sur de la región porque son las más bajas, en las cuales la disminución de las superficies alcanzaría porcentajes entre el 75% y 80% para fines de este siglo, con respecto a las superficies actuales. En estas condiciones es previsible una disminución de la superficie de los glaciares, con un fuerte retroceso de los mismos y la pérdida consiguiente de la reserva de agua en ellos almacenada. En la segunda parte del documento se cuantifica el impacto socioeconómico del cambio climático en las cuencas de Mendoza y San Juan. La reducción de los derrames de los ríos (oferta), el aumento de la demanda y los procesos de degradación del agua, determinaría el aumento del valor social marginal del agua. Mediante modelos de simulación se trazó el valor de corte entre oferta y demanda en el tiempo. La posición y trayectoria temporal del valor social marginal del agua, revelará la magnitud de la escasez, y la velocidad con que esta se incrementa. Estos indican el costo social de la escasez y robustez de la sustentabilidad en cada caso. Se realizan distintas corridas bajo escenarios alternativos para cada cuenca, lo que permite identificar políticas óptimas.

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This collection consists of an autographed copy of Herman F. Arnold’s “Dixie”. The music scale is inscribed with “At the request of Miss Minnie Parker the copy of Dixie is presented to Winthrop College [in 1923] by Prof. Herman F. Arnold + the score in 159 of + who wrote Dixie and was made the war tune of the south at the inauguration of Jefferson Davis Feb. 18th 1861 at Montgomery, Ala.” There is also a note stating that this score is “One of the Four Autograph Copies of the Score of Dixie.” Minnie Barker was curator of the Winthrop museum and the music score was displayed there until Tillman Science Building was razed in 1962 which housed the museum.

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Human N-myc downstream-regulated gene 1 (NDRG1) is a metastasis suppressor gene with several potential functions, including cell differentiation, cell cycle regulation and response to hormones, nickel and stress. The purpose of this study was to investigate the immunoexpression of NDRG1 in oral and oropharyngeal squamous cell carcinomas searching for its role in the clinical course of these tumors. We investigated immunohistochemical expression of NDRG1 protein in 412 tissue microarray cores of tumor samples from 103 patients with oral and oropharyngeal squamous cell carcinomas and in 110 paraffin-embedded surgical margin sections. The results showed NDRG1 up-regulation in 101/103 (98.1 %) tumor samples, but no expression in any normal tissue sample. Western blot assays confirmed the immunohistochemical findings, suggesting that lower levels of NDRG1 are associated with a high mortality rate. NDRG1 overexpression was related to long-term specific survival (HR = 0.38; p = 0.009), whereas the presence of lymph-node metastasis showed the opposite association with survival (HR = 2.45; p = 0.013). Our findings reinforce the idea that NDRG1 plays a metastasis suppressor role in oral and oropharyngeal squamous cell carcinomas and may be a useful marker for these tumors.

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[ES]Contiene: Ceremonia de inauguración/ José Miguel Álamo Mendoza, Fernando Tuya Cortés, Juan Manuel Afonso López -- Presentación del proyecto MACAROMOD/ Óscar Pérez --- Mesa redonda: Acuicultura sostenible/ Fernando Tuya; Ioannis Karakassis; Ricardo Haroun; Pablo Ávila; Gerence Courois --- Mesa redonda: Efectos sobre hábitats y comunidades/ Óscar Monterroso Hoyos; Daniel Montero; Pablo Sánchez Jerez; Paolo Tomassetti; Rodrigo Riera --- Mesa redonda: Control medioambiental de la acuicultura en jaulas/Pablo Sánchez Jerez; Óscar Monterroso; Paolo Tomassetti; Ioannis Karakassis; Cayetano Collado --- Mesa redonda: Ordenación espacila de la acuicultura/ Alejandro Báez; Monstserrat Gimeno; Pablo Sánchez Jerez; José Carlos Macías; Enrique Haro --- Mesa redonda final/ Fernando Tuya