Family-based association analysis with ordered categorical phenotypes, covariates and interactions

Genetic association analyses of family-based studies with ordered categorical phenotypes are often conducted using methods either for quantitative or for binary traits, which can lead to suboptimal analyses. Here we present an alternative likelihood-based method of analysis for single nucleotide polymorphism (SNP) genotypes and ordered categorical phenotypes in nuclear families of any size. Our approach, which extends our previous work for binary phenotypes, permits straightforward inclusion of covariate, gene-gene and gene-covariate interaction terms in the likelihood, incorporates a simple model for ascertainment and allows for family-specific effects in the hypothesis test. Additionally, our method produces interpretable parameter estimates and valid confidence intervals. We assess the proposed method using simulated data, and apply it to a polymorphism in the c-reactive protein (CRP) gene typed in families collected to investigate human systemic lupus erythematosus. By including sex interactions in the analysis, we show that the polymorphism is associated with anti-nuclear autoantibody (ANA) production in females, while there appears to be no effect in males.

HB D Los Angeles in a Brazilian family

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Aplicaciones de los metodos para estimar la cabalidad de los registros a partir de la distribucion por edades de las muertes: a).de William Brass; b).de Samuel Preston; resumen del estudio

A la informacion sobre la distribucion por edades en las muertes registradas a partir de la edad de 5 anos en Chile, Costa Rica, Guatemala, Panama y Peru, se aplican los dos metodos propuestos para evaluar la cabalidad de los registros de defunciones. Los resultados obtenidos de aplicar estos metodos se presentan en graficos y cuadros, con aplicaciones hechas en los 5 paises

Aplicaciones del metodo propuesto por Samuel Preston para medir la cabalidad de censos y registros de muerte (Preston II); resumen del estudio

Este estudio pretende medir la cabalidad de los censos y registros de muertes, utilizando el metodo Preston II con informacion referente a Chile, Costa Rica, Guatemala, Panama y Peru. Se presenta, en lineas generales, el desarrollo teorico del metodo y una forma de determinacion de los valores B1 (cobertura de los censos) y B2 (cobertura del segundo censo y los registros). Se incluyen tabulaciones que contienen los datos utilizados en la aplicacion y los resultados obtenidos para cada pais

Aplicaciones de los métodos para estimar la cabalidad de los registros a partir de la distribución por edades de las muertes: a) de William Brass, b) de Samuel Preston; resumen

Documento de trabajo para el Panel de América Latina, Santiago, 16-20 julio 1979

Aplicaciones del método propuesto por Samuel Preston para medir la cabalidad de los censos y registros de muertes (Preston II); resumen

Documento de trabajo para el Panel de América Latina, Santiago, 16-20 julio 1979

Knox-Wise Family Papers - Accession 591

The Knox-Wise Family Papers includes a land grant issued to John Knox in 1768; diaries written by Dr. John Knox [1792-1859] covering the 1840s and 1850s; James N. Knox [1806-1880] covering 1859-1880; and William D. Knox [1847-1928] covering 1869-1928; indentures, deeds, receipts, court summonses and other papers of Hugh Knox [1757-1821], sheriff and justice of the peace in Chester County, South Carolina (ca. 1780s and 1790s); correspondence of James N. Knox, correspondence, and other professional papers of Dr. John Knox; correspondence, and other papers of William D. Knox, Superintendent of Education in Chester County from 1896-1928. Papers of various other members of the Knox and Wise families including Hugh Boyd Knox [1814-1886], Robert Knox [1796-1879], Sally Knox Wallace [1803-1901], Alexander Walker Wise, and Emmie R. Knox [1885-1969]; family histories of the Knox, Wise, Dunlap, Gaston, and Wilks families; church histories, photographs, and newspaper clippings. Also included are three published volumes of the United Confederate Veterans Minutes of the 21st (1911) and 25th (1915) Annual Meeting and Reunion; and the minutes of the annual reunion of the South Carolina Division of the United Confederate Veterans (1921-1927).

Marshall Family Papers - Accession 260 - M110 (142)

The Marshall Family Papers includes originals and photocopies of two letters written by Fred D. Marshall of Rock Hill. The first is from Camp Thomas in Chickamauga, Georgia and the second was from Camp Cuba Libre in Jacksonville, FL. while he was a soldier during the Spanish American War to his parents, Capt and Mrs. John Wilson Marshall of Rock Hill Also included is a letter by W.W. Byre to Capt. John Wilson Marshall while a missionary in Mexico. Fred D. Marshall served as mayor of Columbia from 1941 to 1946 and W.W. Byre became Dean of Erskine Theological Seminary at Due West, SC.